Page last updated: 2024-09-27

Bunion

Abnormal swelling of the inner aspect of the first metatarsal head affecting the first METATARSOPHALANGEAL JOINT.

Synonyms(1)

Synonym
Bunion

Research

Studies (8)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's6 (75.00)28.8240
2020's2 (25.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaminophen0medium11
bupivacaine0low10
ibuprofen0medium11
indomethacin0medium11
mepivacaine0low10
fluorometholone0low10
titanium0low10
levobupivacaine0low10
ropivacaine0low10
morphine0medium11
mobic0medium11

Protein Targets (301)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma5005
ATAD5 protein, partial1001
GLS protein4004
Microtubule-associated protein tau2002
Smad31001
aldehyde dehydrogenase 1 family, member A11001
thyroid stimulating hormone receptor2002
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha6006
peroxisome proliferator activated receptor gamma4004
aryl hydrocarbon receptor4004
chromobox protein homolog 12002
thyroid hormone receptor beta isoform 23003
peripheral myelin protein 221001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Solute carrier family 22 member 60303
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0202
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0707
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10506
Carbonic anhydrase 30101
Cytochrome P450 3A40213
Cytochrome P450 2D60202
Cytochrome P450 2C9 0404
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-12002
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10404
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20416
Carbonic anhydrase 70101
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Carbonic anhydrase 90101
GABA theta subunit2002
Canalicular multispecific organic anion transporter 10202
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon2002
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
toxin B0001
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
GLI family zinc finger 32002
AR protein4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
glucocorticoid receptor [Homo sapiens]3003
pregnane X nuclear receptor2002
G3003
euchromatic histone-lysine N-methyltransferase 23003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x2002
lysosomal alpha-glucosidase preproprotein1001
huntingtin isoform 21001
flap endonuclease 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
nuclear receptor ROR-gamma isoform 12002
DNA polymerase kappa isoform 13003
Nuclear receptor subfamily 1 group I member 20011
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21102
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
TAR DNA-binding protein 433003
Inositol hexakisphosphate kinase 13003
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial3003
Luciferase3003
USP1 protein, partial1001
NFKB1 protein, partial1001
nonstructural protein 11001
67.9K protein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
arylsulfatase A1001
IDH11001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 13003
geminin2002
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta103003
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Prostaglandin G/H synthase 1 0203
Prostaglandin G/H synthase 2 0203
Dihydrofolate reductase0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0101
Albumin0235
Albumin0101
Albumin0011
Cellular tumor antigen p532002
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0204
UDP-glucuronosyltransferase 2B70001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10202
Caspase-10102
Adenosine receptor A2a0202
Substance-P receptor0202
Prostaglandin G/H synthase 2 0203
UDP-glucuronosyltransferase 1A30002
Aldo-keto reductase family 1 member C30303
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Prostaglandin G/H synthase 20404
Mu-type opioid receptor0303
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20304
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0203
Solute carrier family 22 member 200101
Solute carrier family 22 member 80202
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Cruzipain1001
interleukin 81001
hypoxia-inducible factor 1 alpha subunit2002
SMAD family member 22002
SMAD family member 32002
TDP1 protein3003
estrogen receptor 2 (ER beta)2002
cytochrome P450 family 3 subfamily A polypeptide 43003
farnesoid X nuclear receptor2002
glucocerebrosidase1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
peroxisome proliferator-activated receptor delta2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform a1001
heat shock protein beta-11001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase iota isoform a (long)1001
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Phospholipase A2, major isoenzyme0101
Procathepsin L0101
ATP-dependent translocase ABCB10202
Interleukin-80101
Androgen receptor0011
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Histamine H2 receptor1001
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Spike glycoprotein1001
Guanine nucleotide-binding protein G1001
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Potassium voltage-gated channel subfamily H member 20404
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
histone acetyltransferase KAT2A isoform 11001
Inositol monophosphatase 11001
cytochrome P450 2D61001
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
Chain A, Beta-lactamase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
alpha-galactosidase1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Glutathione reductase, mitochondrial0101
Glucose-6-phosphate 1-dehydrogenase0101
6-phosphogluconate dehydrogenase, decarboxylating0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0011
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0216
Kappa-type opioid receptor0214
Mu-type opioid receptor0214
Delta-type opioid receptor0214
Kappa-type opioid receptor0202
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]