Page last updated: 2024-09-27

Incisional Hernia

Protrusion of tissue at or near the site of an incision from a previous surgery.

Synonyms(2)

Synonym
Postoperative Hernia
Incisional Hernia

Research Excerpts

Overview

ExcerptReference
"Incisional hernias are a frequent complication of laparotomy."( Copotoiu, C; Gherghinescu, MC; Lazar, AE; Mogoanta, SS; Molnar, C; Popa, D, 2017)

Research

Studies (25)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's15 (60.00)28.8240
2020's10 (40.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaminophen0low10
anastrozole0low10
cefuroxime0low10
gentamicin0low20
letrozole0low10
methocarbamol0low10
methylprednisolone0medium11
n-vinyl-2-pyrrolidinone0medium11
silver0low10
titanium0medium21
argon0low10
calcium sulfate0low10
vanadates0low10
cephalosporin c0low10
mt 07030low10
ropivacaine0medium11
tamoxifen0low10
morphine0low10
chlorhexidine0low30
mme0low10

Protein Targets (365)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma5005
ATAD5 protein, partial1001
GLS protein1001
Microtubule-associated protein tau2002
Smad31001
aldehyde dehydrogenase 1 family, member A11001
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor4004
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha6006
peroxisome proliferator activated receptor gamma3003
aryl hydrocarbon receptor3003
chromobox protein homolog 13003
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4004
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0808
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10101
Carbonic anhydrase 20202
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30101
Cytochrome P450 3A40314
Cytochrome P450 2D60101
Cytochrome P450 2C9 0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-14004
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20001
Carbonic anhydrase 70101
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20101
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Carbonic anhydrase 90101
GABA theta subunit4004
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon4004
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
toxin B0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
AR protein5005
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]4004
G5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Aromatase0404
Amine oxidase [flavin-containing] A 0202
UDP-glucuronosyltransferase 1A40102
Spike glycoprotein2013
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, BCL-2-RELATED PROTEIN A10011
Chain A, Cruzipain1001
Luciferase1001
acid sphingomyelinase1001
interleukin 81001
acetylcholinesterase3003
PAX80001
glp-1 receptor, partial1001
15-lipoxygenase, partial1001
pregnane X receptor1001
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
USP1 protein, partial3003
SMAD family member 32002
TDP1 protein2002
GLI family zinc finger 34004
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
PINK11001
estrogen receptor 2 (ER beta)3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
cytochrome P450 2D61001
67.9K protein2002
glucocerebrosidase2002
Parkin1001
peroxisome proliferator-activated receptor delta2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
heat shock protein 900011
caspase-32002
IDH13003
euchromatic histone-lysine N-methyltransferase 22002
calcineurin A1, putative0011
thyroid stimulating hormone receptor2002
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x2002
cytochrome P450 2D6 isoform 12002
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
perilipin-50101
thyroid hormone receptor beta isoform a1001
perilipin-10101
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 32002
heat shock protein beta-12002
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 11001
ubiquitin-conjugating enzyme E2 N0202
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 11001
protein AF-9 isoform a0001
snurportin-11001
melanocortin receptor 40101
nuclear factor erythroid 2-related factor 2 isoform 12002
CAAX prenyl protease0001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 12002
geminin3003
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 12002
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
lethal factor (plasmid)2002
lamin isoform A-delta102002
Synaptojanin-20101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Synaptojanin-10101
Solute carrier family 22 member 30101
Glutathione reductase, mitochondrial0102
Cellular tumor antigen p533003
Integrin beta-32002
72 kDa type IV collagenase0101
Integrin alpha-IIb2002
Matrix metalloproteinase-90101
Trypanothione reductase0101
Alpha-synuclein2002
Histamine H2 receptor2002
TAR DNA-binding protein 432002
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20101
Rap guanine nucleotide exchange factor 41001
Multidrug and toxin extrusion protein 10101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Spermine oxidase0101
runt-related transcription factor 1 isoform AML1b1001
vitamin D3 receptor isoform VDRA2002
core-binding factor subunit beta isoform 21001
Estrogen receptor0315
Steryl-sulfatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
survival motor neuron protein isoform d1001
PPM1D protein2002
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B2002
nuclear receptor subfamily 1, group I, member 21001
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0404
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent phosphofructokinase1001
Opioid receptor, delta 1b 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
ATP-dependent translocase ABCB10314
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0213
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0216
Kappa-type opioid receptor0214
Mu-type opioid receptor0416
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0416
Kappa-type opioid receptor0202
Kappa-type opioid receptor0416
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20303
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10303
Potassium channel subfamily K member 30101
Chain A, CES1 protein0101
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
Fumarate hydratase1001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
regulator of G-protein signaling 41001
polyprotein1001
arylsulfatase A1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
caspase-31001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
M-phase phosphoprotein 81001
streptokinase A precursor0011
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Epidermal growth factor receptor0101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Receptor-type tyrosine-protein phosphatase F0101
Tyrosine-protein phosphatase non-receptor type 20101
Tyrosine-protein phosphatase non-receptor type 10101
Tyrosine-protein phosphatase non-receptor type 60101
Tyrosine-protein phosphatase non-receptor type 110101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]