Page last updated: 2024-09-27

Hallux Rigidus

A condition caused by degenerative arthritis (see OSTEOARTHRITIS) of the METATARSOPHALANGEAL JOINT of the great toe and characterized by pain and limited dorsiflexion, but relatively unrestricted plantar flexion.

Synonyms(1)

Synonym
Hallux Rigidus

Research Excerpts

Overview

ExcerptReference
"Hallux rigidus is a deformity of the first metatarsophalangeal joint."( Dereymaeker, G, 2005)

Treatment

ExcerptReference
"It is an alternative treatment for hallux rigidus in low demand patients."( Ess, P; Hämäläinen, M; Leppilahti, J, 2002)

Research

Studies (29)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's10 (34.48)18.1394
2010's10 (34.48)28.8240
2020's9 (31.03)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bupivacaine0low10
cefuroxime0low10
methylprednisolone acetate0low10
triamcinolone acetonide0medium11
methylprednisolone0low10
limestone0low10
durapatite0low10
titanium0low70
zirconium0low10
trolamine salicylate0low110
delphinidin0medium11
ropivacaine0medium11
vendex0low10

Protein Targets (82)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20011
Potassium channel subfamily K member 90101
Epidermal growth factor receptor0101
Vascular endothelial growth factor receptor 20101
Alpha-synuclein0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
CREB-binding protein0101
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit2002
PPM1D protein1001
GLI family zinc finger 32002
AR protein3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]3003
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha2002
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha3003
G1001
bromodomain adjacent to zinc finger domain 2B1001
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear receptor subfamily 1, group I, member 23003
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin3003
muscleblind-like protein 1 isoform 11001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Nuclear receptor subfamily 1 group I member 20011
Bile salt export pump0303
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Glucocorticoid receptor0404
Glycine receptor subunit alpha-10404
Androgen receptor0202
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Inositol hexakisphosphate kinase 11001
Canalicular multispecific organic anion transporter 10202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
ATP-dependent phosphofructokinase1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
USP1 protein, partial1001
TDP1 protein1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Glucose-6-phosphate 1-dehydrogenase0101
lamin isoform A-delta102002
Chain A, Beta-lactamase1001
SMAD family member 21001
ATAD5 protein, partial1001
SMAD family member 31001
cytochrome P450 family 3 subfamily A polypeptide 41001
retinoic acid nuclear receptor alpha variant 11001
cytochrome P450 2D61001
peroxisome proliferator-activated receptor delta1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
euchromatic histone-lysine N-methyltransferase 21001
aryl hydrocarbon receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
chromobox protein homolog 11001
heat shock protein beta-11001
nuclear receptor ROR-gamma isoform 11001
Cellular tumor antigen p531001
TAR DNA-binding protein 431001
RAR-related orphan receptor gamma1001
phosphopantetheinyl transferase1001
vitamin D3 receptor isoform VDRA1001
DNA polymerase kappa isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]