fluorocholine: a radiopharmaceutical agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 404591 |
| SCHEMBL ID | 7240345 |
| MeSH ID | M0504119 |
| Synonym |
|---|
| ethanaminium,n-dimethyl-n-(fluoromethyl)-2-hydroxy-, chloride |
| nsc-720948 |
| nsc720948 |
| fluorocholine chloride |
| 459424-38-5 |
| n-(fluoromethyl)-2-hydroxy-n,n-dimethylethanaminium chloride |
| AKOS006227819 |
| (fluoromethyl)(2-hydroxyethyl)dimethylazanium chloride |
| FT-0676818 |
| ccris 9400 |
| ethanaminium, n-(fluoromethyl)-2-hydroxy-n,n-dimethyl-, chloride |
| n-fluoromethyl-2-hydroxy-n,n-dimethylethanaminium chloride |
| dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride |
| fluorocholine |
| SCHEMBL7240345 |
| mfcd07995053 |
| AS-72562 |
| ethanaminium,n-(fluoromethyl)-2-hydroxy-n,n-dimethyl-, chloride (9ci) |
| n-fluoromethyl-2-hydroxy-n,n-dimethyl-ethaneammonium chloride |
| n-(fluoromethyl)-2-hydroxy-n,n-dimethylethan-1-aminium chloride |
| W18955 |
| fluoromethyl-(2-hydroxyethyl)-dimethylazanium;chloride |
F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. 18F-fluorcholine PET-CT is a new imaging modality for the localization of pathological parathyroid glands in patients with primary hyperparathyroidism.
18F-Fluorocholine has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in Positron Emission Tomography.
| Excerpt | Reference | Relevance |
|---|---|---|
| "F-fluorocholine has recently emerged as a very sensitive agent for seeking parathyroid adenomas. " | ( Incidental 18F-Fluorocholine Uptake in an Esophageal Diverticulum: 18F-FCH in an Esophageal Diverticulum. Araz, M; Cinel, M; Kucuk, NO; Ozkan, E; Soydal, C, 2020) | 1.63 |
| "18F-Fluorocholine has been suggested as one of the reputable imaging tracers for diagnosis of prostate tumour in Positron Emission Tomography / Computed Tomography (PET/CT) modality. " | ( Optimising the Azeotropic Drying of 18F-Fluorine Wayto Improve the 18F-Fluorocholine Radiochemical Yield. Bakar, SA; Halim, KN; Hassan, H; Idris, J; Nordin, AJ; Saad, FF, 2016) | 1.23 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.36) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 22 (7.94) | 29.6817 |
| 2010's | 169 (61.01) | 24.3611 |
| 2020's | 85 (30.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (32.08) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 23 (7.62%) | 5.53% |
| Reviews | 22 (7.28%) | 6.00% |
| Case Studies | 85 (28.15%) | 4.05% |
| Observational | 3 (0.99%) | 0.25% |
| Other | 169 (55.96%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|
| aminolevulinic acid Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. | 7.15 | 1 | 0 | 4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid | antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite |
| choline [no description available] | 18.69 | 276 | 22 | cholines | allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite |
| dihydroxyphenylalanine Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring. | 3.13 | 1 | 0 | hydroxyphenylalanine; non-proteinogenic alpha-amino acid; tyrosine derivative | human metabolite |
| niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. | 4.3 | 3 | 1 | pyridine alkaloid; pyridinecarboxamide; vitamin B3 | anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor |
| sodium fluoride [no description available] | 7.79 | 3 | 0 | fluoride salt | mutagen |
| fluoroacetic acid fluoroacetic acid: N1 same as NM; RN given refers to parent cpd. fluoroacetic acid : A haloacetic acid that is acetic acid in which one of the methyl hydrogens is substituted by fluorine. | 3.13 | 1 | 0 | haloacetic acid; organofluorine compound | EC 4.2.1.3 (aconitate hydratase) inhibitor |
| edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive. | 3.79 | 3 | 0 | ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid | anticoagulant; antidote; chelator; copper chelator; geroprotector |
| tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring. | 3.19 | 5 | 0 | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
| methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4. | 8.41 | 1 | 0 | aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid | antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical |
| gadolinium Gadolinium: An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors. | 2.08 | 1 | 0 | f-block element atom; lanthanoid atom | |
| deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus. | 2.06 | 1 | 0 | dihydrogen | |
| chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family. | 2.15 | 1 | 0 | diatomic chlorine; gas molecular entity | bleaching agent |
| thallium chloride thallium chloride: RN given refers to unlabeled parent cpd | 2.11 | 1 | 0 | inorganic chloride; thallium molecular entity | |
| misonidazole Misonidazole: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic. | 7.11 | 1 | 0 | ||
| fluorides [no description available] | 2.48 | 2 | 0 | halide anion; monoatomic fluorine | |
| phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid. | 7.91 | 5 | 1 | benzenes; phenyl acetates | |
| alovudine [no description available] | 3.13 | 1 | 0 | pyrimidine 2',3'-dideoxyribonucleoside | |
| fluorodopa f 18 fluorodopa F 18: RN given refers to (L)-isomer | 3.13 | 1 | 0 | (18)F radiopharmaceutical; 6-fluoro-L-dopa | |
| 16-fluoroestradiol 16-fluoroestradiol: RN refers to (16beta,17beta)-isomer | 3.13 | 1 | 0 | ||
| fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162) | 12.09 | 35 | 4 | 2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose | |
| cryptating agent 222 cryptating agent 222: forms ligands with metal cations; structure | 2.04 | 1 | 0 | ||
| fluoromisonidazole [no description available] | 7.11 | 1 | 0 | ||
| 2'-(2-hydroxyphenyl)-2'-thiazoline-4'-carboxylic acid 2-(2-hydroxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid : A monocarboxylic acid consisting of 2-(2-hydroxyphenyl)-4,5-dihydrothiazole having a carboxy group at the 4-position. | 2.6 | 1 | 0 | imidothioate; monocarboxylic acid | |
| n-nitrosothiazolidine-4-carboxylic acid N-nitrosothiazolidine-4-carboxylic acid: found in human urine | 2.6 | 1 | 0 | organonitrogen compound; organooxygen compound | |
| abiraterone [no description available] | 9.77 | 3 | 2 | 3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; pyridines | antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor |
| docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group. | 2.51 | 2 | 0 | secondary alpha-hydroxy ketone; tetracyclic diterpenoid | antimalarial; antineoplastic agent; photosensitizing agent |
| organophosphonates hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid. | 3.5 | 1 | 1 | divalent inorganic anion; phosphite ion | |
| n,n-dimethyl-n-(18f)fluoromethyl-2-hydroxyethylammonium [no description available] | 8.79 | 23 | 2 | ||
| carbon-11 acetate carbon-11 acetate: a tracer of myocardial oxygen consumption | 2.15 | 1 | 0 | ||
| fluciclovine f-18 fluciclovine F-18: A radioactive diagnostic agent used for the detection of recurrent prostate cancer by POSITRON EMISSION TOMOGRAPHY; structure in first source. | 4.14 | 1 | 0 | ||
| thallium Thallium: A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.. thallium : A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot). | 2.11 | 1 | 0 | boron group element atom | |
| radium Radium: A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra and atomic number 88. Radium is the product of the disintegration of URANIUM and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY. | 10.05 | 8 | 0 | alkaline earth metal atom | |
| 18f-fluoroethyl-l-tyrosine (18F)fluoroethyltyrosine: structure in first source | 2.55 | 2 | 0 | ||
| losartan potassium Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation. | 2.08 | 1 | 0 | ||
| mdv 3100 [no description available] | 4.22 | 3 | 1 | (trifluoromethyl)benzenes; benzamides; imidazolidinone; monofluorobenzenes; nitrile; thiocarbonyl compound | androgen antagonist; antineoplastic agent |
| technetium tc 99m sestamibi Technetium Tc 99m Sestamibi: A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack. | 9.14 | 24 | 1 | ||
| sodium pertechnetate tc 99m Sodium Pertechnetate Tc 99m: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints. | 2.15 | 1 | 0 | ||
| o-(2-fluoroethyl)tyrosine O-(2-fluoroethyl)tyrosine: structure in first source | 2.44 | 2 | 0 | ||
| bay 86-7548 BAY 86-7548: (68)Ga-bombesin antagonist | 2.21 | 1 | 0 | ||
| psma-617 PSMA-617: inhibits prostate-specific membrane antigen; structure in first source | 2.21 | 1 | 0 | ||
| gallium ga 68 dotatate gallium Ga 68 dotatate: A radioactive diagnostic agent used for POSITRON EMISSION TOMOGRAPHY (PET) imaging of SOMATOSTATIN RECEPTOR positive neuroendocrine tumors and malignant abdominal paraganglioma. | 3.25 | 1 | 0 | ||
| technetium tc 99m medronate Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms. | 2.17 | 1 | 0 |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Benign Neoplasms, Brain [description not available] | 0 | 6.81 | 21 | 0 |
| Glial Cell Tumors [description not available] | 0 | 5.59 | 15 | 1 |
| Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 6.81 | 21 | 0 |
| Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 5.59 | 15 | 1 |
| Primary Hyperparathyroidism [description not available] | 0 | 11.03 | 52 | 2 |
| Cancer of Parathyroid [description not available] | 0 | 9.42 | 36 | 1 |
| Parathyroid Neoplasms Tumors or cancer of the PARATHYROID GLANDS. | 0 | 9.42 | 36 | 1 |
| Hyperparathyroidism, Primary A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION. | 0 | 11.03 | 52 | 2 |
| Cancer of the Thyroid [description not available] | 0 | 3.4 | 6 | 0 |
| Thyroid Neoplasms Tumors or cancer of the THYROID GLAND. | 0 | 3.4 | 6 | 0 |
| Thyroid Nodule A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR). | 0 | 3.3 | 4 | 0 |
| Adenopathy [description not available] | 0 | 2.9 | 2 | 0 |
| 2019 Novel Coronavirus Disease [description not available] | 0 | 3.45 | 5 | 0 |
| Cancer of Prostate [description not available] | 0 | 16.3 | 125 | 10 |
| Local Neoplasm Recurrence [description not available] | 0 | 12.29 | 39 | 5 |
| Prostatic Neoplasms Tumors or cancer of the PROSTATE. | 0 | 16.3 | 125 | 10 |
| Breast Cancer [description not available] | 0 | 7.86 | 3 | 0 |
| Breast Neoplasms Tumors or cancer of the human BREAST. | 0 | 2.86 | 3 | 0 |
| Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 9.39 | 26 | 4 |
| Hyperparathyroidism A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES. | 0 | 4.76 | 9 | 0 |
| Multiple Endocrine Neoplasia Type 1 A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13). | 0 | 7.72 | 2 | 0 |
| Cancer, Second Primary [description not available] | 0 | 2.61 | 2 | 0 |
| Lymph Node Metastasis [description not available] | 0 | 11.36 | 25 | 3 |
| Hepatocellular Carcinoma [description not available] | 0 | 9.55 | 13 | 3 |
| Cancer of Liver [description not available] | 0 | 10.53 | 17 | 4 |
| Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. | 0 | 9.55 | 13 | 3 |
| Liver Neoplasms Tumors or cancer of the LIVER. | 0 | 10.53 | 17 | 4 |
| Adenoma, Basal Cell [description not available] | 0 | 6.87 | 20 | 1 |
| Adenoma A benign epithelial tumor with a glandular organization. | 0 | 6.87 | 20 | 1 |
| Bone Cancer [description not available] | 0 | 8.16 | 20 | 1 |
| Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES. | 0 | 8.16 | 20 | 1 |
| Hemorrhagic Thrombocythemia [description not available] | 0 | 2.6 | 1 | 0 |
| Thrombocythemia, Essential A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets. | 0 | 2.6 | 1 | 0 |
| Brain Abscess A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6) | 0 | 2.6 | 1 | 0 |
| Cerebral Nocardiosis [description not available] | 0 | 2.6 | 1 | 0 |
| Osteitis Fibrosa Cystica A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM. | 0 | 2.72 | 2 | 0 |
| Milk-Alkali Syndrome [description not available] | 0 | 2.82 | 2 | 0 |
| Hypercalcemia Abnormally high level of calcium in the blood. | 0 | 2.82 | 2 | 0 |
| Recrudescence [description not available] | 0 | 6.85 | 12 | 2 |
| Carcinoma, Anaplastic [description not available] | 0 | 2.58 | 2 | 0 |
| Cancer of Head [description not available] | 0 | 2.25 | 1 | 0 |
| Metastase [description not available] | 0 | 11.42 | 14 | 3 |
| Androgen-Independent Prostatic Cancer [description not available] | 0 | 8.47 | 15 | 3 |
| Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer. | 0 | 7.58 | 2 | 0 |
| Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) | 0 | 2.25 | 1 | 0 |
| Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 6.42 | 14 | 3 |
| Prostatic Neoplasms, Castration-Resistant Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE. | 0 | 8.47 | 15 | 3 |
| AL Amyloidosis [description not available] | 0 | 2.25 | 1 | 0 |
| Immunoglobulin Light-chain Amyloidosis A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies. | 0 | 2.25 | 1 | 0 |
| Diverticula, Esophageal [description not available] | 0 | 2.25 | 1 | 0 |
| Disease Exacerbation [description not available] | 0 | 7.73 | 10 | 2 |
| Angiogenesis, Pathologic [description not available] | 0 | 2.49 | 2 | 0 |
| Innate Inflammatory Response [description not available] | 0 | 3.5 | 2 | 0 |
| Cavernitis, Fibrous [description not available] | 0 | 2.25 | 1 | 0 |
| Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 8.5 | 2 | 0 |
| Penile Induration A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both. | 0 | 2.25 | 1 | 0 |
| Infections, Coronavirus [description not available] | 0 | 2.66 | 2 | 0 |
| Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection. | 0 | 2.66 | 2 | 0 |
| Coronavirus Infections Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE). | 0 | 2.66 | 2 | 0 |
| Convalescence The period of recovery following an illness. | 0 | 2.25 | 1 | 0 |
| Adenocarcinoma, Basal Cell [description not available] | 0 | 5.23 | 10 | 0 |
| Adenocarcinoma A malignant epithelial tumor with a glandular organization. | 0 | 10.23 | 10 | 0 |
| Kahler Disease [description not available] | 0 | 2.58 | 2 | 0 |
| Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. | 0 | 2.58 | 2 | 0 |
| Carcinoma, Small Cell Lung [description not available] | 0 | 2.31 | 1 | 0 |
| Cancer of Lung [description not available] | 0 | 4.41 | 4 | 1 |
| Lung Neoplasms Tumors or cancer of the LUNG. | 0 | 4.41 | 4 | 1 |
| Small Cell Lung Carcinoma A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA). | 0 | 2.31 | 1 | 0 |
| Cancer of Penis [description not available] | 0 | 2.31 | 1 | 0 |
| Penile Neoplasms Cancers or tumors of the PENIS or of its component tissues. | 0 | 2.31 | 1 | 0 |
| Cancer of Intestines [description not available] | 0 | 2.31 | 1 | 0 |
| Cancer of Pancreas [description not available] | 0 | 2.31 | 1 | 0 |
| Cancer of Stomach [description not available] | 0 | 2.31 | 1 | 0 |
| Intestinal Neoplasms Tumors or cancer of the INTESTINES. | 0 | 2.31 | 1 | 0 |
| Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). | 0 | 2.31 | 1 | 0 |
| Stomach Neoplasms Tumors or cancer of the STOMACH. | 0 | 2.31 | 1 | 0 |
| Neuroendocrine Tumors Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. | 0 | 3.76 | 3 | 0 |
| Angioma A vascular anomaly due to proliferation of blood or lymphatic vessels that forms a tumor-like mass. Vessels in the angioma may or may not be dilated. | 0 | 2.58 | 2 | 0 |
| Cancer of Spleen [description not available] | 0 | 2.25 | 1 | 0 |
| Hemangioma A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000) | 0 | 2.58 | 2 | 0 |
| Air Embolism [description not available] | 0 | 7.31 | 1 | 0 |
| Acoustic Neuroma [description not available] | 0 | 2.31 | 1 | 0 |
| Secondary Hyperparathyroidism [description not available] | 0 | 3.23 | 5 | 0 |
| CKD-MBD [description not available] | 0 | 2.63 | 2 | 0 |
| Hyperparathyroidism, Secondary Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY. | 0 | 3.23 | 5 | 0 |
| Chronic Kidney Disease-Mineral and Bone Disorder Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. | 0 | 2.63 | 2 | 0 |
| Benign Cerebellar Neoplasms [description not available] | 0 | 2.57 | 2 | 0 |
| Diffuse Mixed Small and Large Cell Lymphoma [description not available] | 0 | 2.31 | 1 | 0 |
| Diffuse Large B-Cell Lymphoma [description not available] | 0 | 2.31 | 1 | 0 |
| Central Nervous System Neoplasm [description not available] | 0 | 2.31 | 1 | 0 |
| Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. | 0 | 2.31 | 1 | 0 |
| Lymphoma, Large B-Cell, Diffuse Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. | 0 | 2.31 | 1 | 0 |
| Central Nervous System Neoplasms Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges. | 0 | 2.31 | 1 | 0 |
| Cancer of Mediastinum [description not available] | 0 | 3.06 | 1 | 0 |
| Mediastinal Neoplasms Tumors or cancer of the MEDIASTINUM. | 0 | 3.06 | 1 | 0 |
| Breast Cancer, Male [description not available] | 0 | 2.57 | 2 | 0 |
| Breast Neoplasms, Male Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females. | 0 | 2.57 | 2 | 0 |
| Astrocytoma, Grade IV [description not available] | 0 | 3.36 | 6 | 0 |
| Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. | 0 | 3.36 | 6 | 0 |
| Malignant Melanoma [description not available] | 0 | 2.17 | 1 | 0 |
| Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 0 | 7.17 | 1 | 0 |
| Carcinoma, Thymic [description not available] | 0 | 2.17 | 1 | 0 |
| Cancer of the Thymus [description not available] | 0 | 2.17 | 1 | 0 |
| Thymoma A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed) | 0 | 7.17 | 1 | 0 |
| Thymus Neoplasms Tumors or cancer of the THYMUS GLAND. | 0 | 2.17 | 1 | 0 |
| Adenocarcinoma Of Kidney [description not available] | 0 | 2.17 | 1 | 0 |
| Cancer of Kidney [description not available] | 0 | 2.17 | 1 | 0 |
| Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. | 0 | 2.17 | 1 | 0 |
| Kidney Neoplasms Tumors or cancers of the KIDNEY. | 0 | 2.17 | 1 | 0 |
| Brain Hemorrhage, Cerebral [description not available] | 0 | 2.21 | 1 | 0 |
| Cerebral Hemorrhage Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA. | 0 | 2.21 | 1 | 0 |
| Minimal Disease, Residual [description not available] | 0 | 2.21 | 1 | 0 |
| Cerebral Ischemia [description not available] | 0 | 2.21 | 1 | 0 |
| Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. | 0 | 2.21 | 1 | 0 |
| Neoplasms, Plasma Cell Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS. | 0 | 2.21 | 1 | 0 |
| Familial Nonmedullary Thyroid Cancer [description not available] | 0 | 2.57 | 2 | 0 |
| Carcinoma, Epidermoid [description not available] | 0 | 2.21 | 1 | 0 |
| Cancer of Larynx [description not available] | 0 | 2.21 | 1 | 0 |
| Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) | 0 | 2.21 | 1 | 0 |
| Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS. | 0 | 2.21 | 1 | 0 |
| Diseases, Metabolic [description not available] | 0 | 2.21 | 1 | 0 |
| Metabolic Diseases Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed) | 0 | 2.21 | 1 | 0 |
| Inflammatory Pseudotumor [description not available] | 0 | 7.21 | 1 | 0 |
| Granuloma, Plasma Cell A slow-growing benign pseudotumor in which plasma cells greatly outnumber the inflammatory cells. | 0 | 2.21 | 1 | 0 |
| Carcinoma, Neuroendocrine A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round blue cells, granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (oat) cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992) | 0 | 2.57 | 2 | 0 |
| Cafe-au-Lait Spots with Pulmonic Stenosis [description not available] | 0 | 2.51 | 2 | 0 |
| Neurofibromatosis 1 An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS). | 0 | 2.51 | 2 | 0 |
| Chromosome Deletion Actual loss of portion of a chromosome. | 0 | 3.59 | 1 | 1 |
| Alogia [description not available] | 0 | 2.08 | 1 | 0 |
| Brachial Paresis [description not available] | 0 | 2.08 | 1 | 0 |
| Astroblastoma [description not available] | 0 | 2.08 | 1 | 0 |
| Aphasia A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia. | 0 | 2.08 | 1 | 0 |
| Neoplasms, Neuroepithelial Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5) | 0 | 2.08 | 1 | 0 |
| Germinoblastoma [description not available] | 0 | 2.08 | 1 | 0 |
| Lymphoma A general term for various neoplastic diseases of the lymphoid tissue. | 0 | 7.08 | 1 | 0 |
| Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. | 0 | 8.42 | 2 | 0 |
| Benign Neoplasms [description not available] | 0 | 7.51 | 6 | 1 |
| Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 7.51 | 6 | 1 |
| Anthracosis A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal MINERS, but can be seen in urban dwellers and tobacco smokers. | 0 | 2.11 | 1 | 0 |
| Cancer, Embryonal [description not available] | 0 | 2.11 | 1 | 0 |
| Mixed Pineocytoma-Pineoblastoma [description not available] | 0 | 2.11 | 1 | 0 |
| Brain Ventricular Neoplasms [description not available] | 0 | 2.11 | 1 | 0 |
| Neoplasms, Germ Cell and Embryonal Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS. | 0 | 2.11 | 1 | 0 |
| Pinealoma Neoplasms which originate from pineal parenchymal cells that tend to enlarge the gland and be locally invasive. The two major forms are pineocytoma and the more malignant pineoblastoma. Pineocytomas have moderate cellularity and tend to form rosette patterns. Pineoblastomas are highly cellular tumors containing small, poorly differentiated cells. These tumors occasionally seed the neuroaxis or cause obstructive HYDROCEPHALUS or Parinaud's syndrome. GERMINOMA; CARCINOMA, EMBRYONAL; GLIOMA; and other neoplasms may arise in the pineal region with germinoma being the most common pineal region tumor. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2064; Adams et al., Principles of Neurology, 6th ed, p670) | 0 | 2.11 | 1 | 0 |
| Neurofibroma A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) | 0 | 7.11 | 1 | 0 |
| Multiple Primary Neoplasms [description not available] | 0 | 2.48 | 2 | 0 |
| Chronic Kidney Failure [description not available] | 0 | 2.13 | 1 | 0 |
| Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. | 0 | 2.13 | 1 | 0 |
| Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 2.13 | 1 | 0 |
| Carcinoma, Papillary A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed) | 0 | 2.13 | 1 | 0 |
| Spinal Neoplasms New abnormal growth of tissue in the SPINE. | 0 | 2.13 | 1 | 0 |
| Asymptomatic Conditions [description not available] | 0 | 3.04 | 1 | 0 |
| Atheroma [description not available] | 0 | 8.04 | 1 | 0 |
| Rupture, Spontaneous Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force. | 0 | 3.04 | 1 | 0 |
| Carotid Artery Narrowing [description not available] | 0 | 3.04 | 1 | 0 |
| Carotid Stenosis Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3) | 0 | 3.04 | 1 | 0 |
| Injuries, Radiation [description not available] | 0 | 2.47 | 2 | 0 |
| Adenocarcinoma, Alveolar [description not available] | 0 | 3.44 | 1 | 1 |
| Adenocarcinoma, Bronchiolo-Alveolar A carcinoma derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed) | 0 | 3.44 | 1 | 1 |
| Invasiveness, Neoplasm [description not available] | 0 | 2.05 | 1 | 0 |
| Adenoma, Hepatocellular [description not available] | 0 | 3.45 | 1 | 1 |
| Focal Nodular Hyperplasia Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen. | 0 | 8.45 | 1 | 1 |
| Chronic Illness [description not available] | 0 | 4.36 | 1 | 1 |
| Cirrhosis, Liver [description not available] | 0 | 4.36 | 1 | 1 |
| Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 4.36 | 1 | 1 |
| Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 4.36 | 1 | 1 |
| Anaplastic Oligodendroglioma [description not available] | 0 | 2.06 | 1 | 0 |
| Oligodendroglioma A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655) | 0 | 2.06 | 1 | 0 |
| Adrenal Cancer [description not available] | 0 | 2.08 | 1 | 0 |
| Acute Brain Injuries [description not available] | 0 | 2.03 | 1 | 0 |
| Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. | 0 | 2.03 | 1 | 0 |
| Calculosis [description not available] | 0 | 2.03 | 1 | 0 |
| Submandibular Gland Diseases Diseases involving the SUBMANDIBULAR GLAND. | 0 | 2.03 | 1 | 0 |
| Cancer of Esophagus [description not available] | 0 | 3.87 | 1 | 0 |
| Cancer of Nasopharynx [description not available] | 0 | 3.87 | 1 | 0 |
| Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. | 0 | 3.87 | 1 | 0 |
| Nasopharyngeal Neoplasms Tumors or cancer of the NASOPHARYNX. | 0 | 3.87 | 1 | 0 |
| Cancer of Digestive System [description not available] | 0 | 2.04 | 1 | 0 |
| Cancer of Endocrine Gland [description not available] | 0 | 2.04 | 1 | 0 |
| Digestive System Neoplasms Tumors or cancer of the DIGESTIVE SYSTEM. | 0 | 2.04 | 1 | 0 |
| Endocrine Gland Neoplasms Tumors or cancer of the ENDOCRINE GLANDS. | 0 | 2.04 | 1 | 0 |