Page last updated: 2024-10-26

etidronate and Hyperparathyroidism

etidronate has been researched along with Hyperparathyroidism in 26 studies

Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.

Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"To define the nature, incidence and consequence of a possible interaction between etidronate (for the treatment of hypercalcemia) and methylene diphosphonate labelled with technetium-99m (99mTc-MDP) (for bone scanning)."3.69Etidronate therapy decreases the sensitivity of bone scanning with methylene diphosphonate labelled with technetium-99m. ( Line, BR; Malfetano, J; Murphy, KJ, 1997)
"Urinary deoxypyridinoline, a bone resorption marker, decreased by 46."2.73Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease. ( Honda, Y; Iwamoto, J; Sato, Y, 2007)
"Indomethacin was effective in only one of five patients to whom it was given, and EHDP was effective also in only one of five patients."2.65Comparative study of available medical therapy for hypercalcemia of malignancy. ( Heath, DA; Mundy, GR; Wilkinson, R, 1983)
"Histologic proof of renal osteodystrophy had been obtained in all patients."1.26Bone scintigraphy in renal osteodystrophy. ( de Graaf, P; de Graeff, J; Pauwels, EK; Schicht, IM; te Velde, J, 1978)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199017 (65.38)18.7374
1990's6 (23.08)18.2507
2000's2 (7.69)29.6817
2010's1 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brookler, KH1
Sato, Y2
Honda, Y2
Umeno, K1
Hayashida, N1
Iwamoto, J2
Takeda, T1
Matsumoto, H1
Mundy, GR2
Wilkinson, R1
Heath, DA1
Delmas, PD1
Meunier, PJ1
Fogelman, I2
Bessent, RG2
Gay, JD1
Poznanski, WJ1
Licata, AA1
O'Hanlon, E1
De Graaf, P2
Schicht, IM2
Te Velde, J2
Pauwels, EK2
Kleiverda, K1
De Graeff, J2
Amoroso, A1
Petroni, S1
Cavina, G1
Caccavo, D1
Raisz, LG1
Steiniche, T1
Rodan, GA1
Seedor, JG1
Balena, R1
Reasner, CA1
Stone, MD1
Hosking, DJ1
Ballah, A1
Forbes, RB1
Grant, DJ1
MacWalter, RS1
Murphy, KJ1
Line, BR1
Malfetano, J1
Alexandre, C1
Chapuy, MC1
Meunier, P1
Walton, RJ1
Smith, R1
Russell, RG1
Kaplan, RA1
Geho, WB1
Poindexter, C1
Haussler, M1
Dietz, GW1
Pak, CY1
Greig, WR1
Boyle, IT1
Rosen, C1
Segal, H1
Hartz, CE1
Mroz, F1
Carlton, E1
Foldes, J1
Halperin, Y1
Kidroni, G1
Menczel, J1
Sasaki, H1
Miyake, K1
Okumura, M1
Eimoto, T1
Fleisch, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420]Phase 14 participants (Actual)Interventional2005-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for etidronate and Hyperparathyroidism

ArticleYear
Bone histomorphometry in the pathophysiological evaluation of primary and secondary osteoporosis and various treatment modalities.
    APMIS. Supplementum, 1995, Volume: 51

    Topics: Adult; Aged; Aging; Benzothiadiazines; Bone and Bones; Calcium; Diuretics; Estrogens; Etidronic Acid

1995
Preclinical pharmacology of alendronate.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 1993, Volume: 3 Suppl 3

    Topics: Alendronate; Animals; Calcification, Physiologic; Diphosphonates; Disease Models, Animal; Estrogens;

1993
[Biphosphonate as a therapeutic drug--experimental studies and clinical application].
    Therapeutische Umschau. Revue therapeutique, 1985, Volume: 42, Issue:6

    Topics: Animals; Calcinosis; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Hyperpar

1985

Trials

4 trials available for etidronate and Hyperparathyroidism

ArticleYear
The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial.
    The Kurume medical journal, 2011, Volume: 57, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bone Density; Bone Density Conservation Agents; Etidroni

2011
Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
    Neurology, 2007, Mar-20, Volume: 68, Issue:12

    Topics: Aged; Aged, 80 and over; Amino Acids; Biomarkers; Bone Density; Bone Density Conservation Agents; Bo

2007
Comparative study of available medical therapy for hypercalcemia of malignancy.
    The American journal of medicine, 1983, Volume: 74, Issue:3

    Topics: Administration, Oral; Adult; Aged; Calcium; Clinical Trials as Topic; Diphosphonates; Etidronic Acid

1983
Metabolic effects of diphosphonate in primary hyperparathyroidism.
    Journal of clinical pharmacology, 1977, Volume: 17, Issue:7

    Topics: Adult; Aged; Alkaline Phosphatase; Bone and Bones; Calcium; Clinical Trials as Topic; Cyclic AMP; Di

1977

Other Studies

19 other studies available for etidronate and Hyperparathyroidism

ArticleYear
Monaural diplacusis with tinnitus, aural fullness, hyperacusis, and sensorineural hearing loss.
    Ear, nose, & throat journal, 2009, Volume: 88, Issue:2

    Topics: Bone Density Conservation Agents; Diabetes Mellitus, Type 2; Etidronic Acid; Hearing Loss, Sensorine

2009
Medical management of primary hyperparathyroidism.
    Lancet (London, England), 1984, Sep-29, Volume: 2, Issue:8405

    Topics: Aged; Clodronic Acid; Estrogens; Etidronic Acid; Humans; Hyperparathyroidism; Middle Aged

1984
[Diphosphonates in the treatment of hypercalcemia].
    La Revue de medecine interne, 1984, Volume: 5, Issue:4

    Topics: Bone Neoplasms; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Hypercalcemia; Hyperparathyr

1984
The effect of parathyroid hormone on technetium-99m pyrophosphate distribution in rats.
    European journal of nuclear medicine, 1981, Volume: 6, Issue:5

    Topics: Animals; Diphosphates; Etidronic Acid; Humans; Hyperparathyroidism; Organotechnetium Compounds; Radi

1981
Hyperparathyroidism in Paget's disease of bone.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1983, Volume: 6, Issue:2

    Topics: Aged; Calcium; Cyclic AMP; Etidronic Acid; Female; Humans; Hyperparathyroidism; Male; Middle Aged; O

1983
Treatment of hyperparathyroidism with etidronate disodium.
    JAMA, 1983, Apr-15, Volume: 249, Issue:15

    Topics: Aged; Alkaline Phosphatase; Calcium; Etidronic Acid; Female; Humans; Hyperparathyroidism; Pain; Phos

1983
Quantitative bone scintigraphy in evaluating treatment of renal osteodystrophy.
    The Netherlands journal of medicine, 1983, Volume: 26, Issue:5

    Topics: Bone and Bones; Chronic Kidney Disease-Mineral and Bone Disorder; Etidronic Acid; Humans; Hyperparat

1983
[Hypercalcemic syndromes].
    Recenti progressi in medicina, 1984, Volume: 75, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Benzothiadiazines; Child; Diphosphonates; Diuretics; Etidronic Acid;

1984
New diphosphonates to block bone resorption.
    The New England journal of medicine, 1980, Feb-07, Volume: 302, Issue:6

    Topics: Animals; Bone Resorption; Breast Neoplasms; Clodronic Acid; Diphosphonates; Double-Blind Method; Eti

1980
Acute changes in calcium homeostasis during treatment of primary hyperparathyroidism with risedronate.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:4

    Topics: Administration, Oral; Aged; Alkaline Phosphatase; Analysis of Variance; Bone Resorption; Calcium; Et

1993
Cyclical etidronate and calcium carbonate (with citrate) supplementation for osteoporosis unmasking primary hyperparathyroidism.
    Scottish medical journal, 1995, Volume: 40, Issue:6

    Topics: Aged; Aged, 80 and over; Antacids; Calcium; Calcium Carbonate; Citrates; Citric Acid; Diagnosis, Dif

1995
Etidronate therapy decreases the sensitivity of bone scanning with methylene diphosphonate labelled with technetium-99m.
    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 1997, Volume: 48, Issue:3

    Topics: Administration, Oral; Aged; Bone and Bones; Bone Diseases; Bone Neoplasms; Contraindications; Drug I

1997
Bone scintigraphy in renal osteodystrophy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1978, Volume: 19, Issue:12

    Topics: Adolescent; Adult; Alkaline Phosphatase; Bone and Bones; Chronic Kidney Disease-Mineral and Bone Dis

1978
[The hypocalcemia test, using human and salmon synthetic calcitonins. Paradoxical hypercalcemic responses. Responses in patients with Paget's disease treated with EHDP].
    Revue du rhumatisme et des maladies osteo-articulaires, 1979, Volume: 46, Issue:5

    Topics: Calcitonin; Calcium; Dose-Response Relationship, Drug; Etidronic Acid; Hormones; Humans; Hyperparath

1979
Effects of a diphosphonate (disodium etidronate: EHDP) on phosphate metabolism in Paget's disease of bone, primary hyperparathyroidism and type I hypophosphataemic rickets.
    Calcified tissue research, 1976, Volume: 21 Suppl

    Topics: Etidronic Acid; Humans; Hyperparathyroidism; Hypophosphatemia, Familial; Kidney; Kidney Tubules; Org

1976
Skeletal uptake of Tc-99m HEDP in primary hyperparathyroidism.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:10

    Topics: Bone and Bones; Etidronic Acid; Humans; Hyperparathyroidism; Radionuclide Imaging; Technetium

1977
Primary hyperparathyroidism in an elderly patient with multiple myeloma.
    Journal of the American Geriatrics Society, 1992, Volume: 40, Issue:7

    Topics: Aged; Aged, 80 and over; Calcium; Cyclic AMP; Etidronic Acid; Humans; Hypercalcemia; Hyperparathyroi

1992
Medical treatment of primary hyperparathyroidism: effects on parathormone and vitamin D metabolites.
    Israel journal of medical sciences, 1987, Volume: 23, Issue:11

    Topics: Calcitonin; Cimetidine; Dihydroxycholecalciferols; Drug Therapy, Combination; Etidronic Acid; Female

1987
[Failure of cimetidine and etidronate disodium to suppress parathyroid hormone level and hypercalcemia in primary hyperparathyroidism].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1988, Volume: 77, Issue:1

    Topics: Adenoma; Aged; Alkaline Phosphatase; Cimetidine; Etidronic Acid; Humans; Hypercalcemia; Hyperparathy

1988
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