indomethacin has been researched along with Hyperparathyroidism in 7 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin was effective in only one of five patients to whom it was given, and EHDP was effective also in only one of five patients." | 2.65 | Comparative study of available medical therapy for hypercalcemia of malignancy. ( Heath, DA; Mundy, GR; Wilkinson, R, 1983) |
| " Both PGE1 and PGE2 enhanced cellular release of parathyroid hormone, with dose-response characteristics similar to those seen with cAMP." | 1.26 | Prostaglandin-mediated stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed human parathyroid cells. ( Attie, MF; Aurbach, GD; Brown, EM; Gardner, DG, 1980) |
| "The treatment of hypercalcemia is directed toward immediate correction of the electrolyte imbalance and long-term control." | 1.26 | Genitourinary malignancy and pseudohyperparathyroidism. ( Barry, JM; Carey, TC; Metcalfe, JB, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mundy, GR | 1 |
| Wilkinson, R | 1 |
| Heath, DA | 1 |
| Gardner, DG | 1 |
| Brown, EM | 1 |
| Attie, MF | 1 |
| Aurbach, GD | 1 |
| Kukreja, SC | 1 |
| Yamamoto, M | 1 |
| Rapoport, B | 1 |
| Clark, OH | 1 |
| Feingold, K | 1 |
| Seyberth, HW | 1 |
| Segre, GV | 1 |
| Hamet, P | 1 |
| Sweetman, BJ | 1 |
| Potts, JT | 1 |
| Oates, JA | 1 |
| Metcalfe, JB | 1 |
| Carey, TC | 1 |
| Barry, JM | 1 |
| Phelps, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for indomethacin and Hyperparathyroidism
| Article | Year |
|---|---|
Comparative study of available medical therapy for hypercalcemia of malignancy.
Topics: Administration, Oral; Adult; Aged; Calcium; Clinical Trials as Topic; Diphosphonates; Etidronic Acid | 1983 |
6 other studies available for indomethacin and Hyperparathyroidism
| Article | Year |
|---|---|
Prostaglandin-mediated stimulation of adenosine 3',5'-monophosphate accumulation and parathyroid hormone release in dispersed human parathyroid cells.
Topics: Animals; Cattle; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Hyperparathyroidism; Indometh | 1980 |
Diagnosis and management of hypercalcemia.
Topics: Calcitonin; Glucocorticoids; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasms; Ph | 1980 |
Studies on the pathophysiological role of thyroidal prostaglandin E (PGE) in Graves' disease.
Topics: Adult; Aged; Female; Graves Disease; Humans; Hyperparathyroidism; Indomethacin; Male; Middle Aged; P | 1980 |
Characterization of the group of patients with the hypercalcemia of cancer who respond to treatment with prostaglandin synthesis inhibitors.
Topics: Aspirin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasm Met | 1976 |
Genitourinary malignancy and pseudohyperparathyroidism.
Topics: Carcinoma, Squamous Cell; Castration; Dysgerminoma; Female; Furosemide; Humans; Hypercalcemia; Hyper | 1978 |
Nongouty crystal deposit arthritis.
Topics: Adrenocorticotropic Hormone; Aspirin; Bursitis; Chondrocalcinosis; Colchicine; Heart Failure; Humans | 1971 |