17-ketosteroids and Hyperparathyroidism

A patient with adrenocortical carcinoma had three major endocrine abnormalities attributable directly to the tumor: hypercortisolism (Cushing's syndrome), hyperestrogenism (feminization), and hypercalcemia (pseudohyperparathyroidism). There were higher levels of immunoreactive parathyroid hormone in venous effluent from the tumor or its abdominal metastases compared to that found in the veins draining the parathyroid glands. This, together with the presence of normal parathyroid glands on autopsy, established the diagnosis of pseudohyperparathyroidism as the cause of hypercalcemia in this patient.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adult; Aminoglutethimide; Androstenedione; Cushing Syndrome; Dexamethasone; Estrogens; Feminization; Humans; Hyperparathyroidism; Male; Metyrapone; Mitotane; Paraneoplastic Endocrine Syndromes; Parathyroid Hormone; Testosterone

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Calcium; Diagnosis, Differential; Humans; Hyperparathyroidism; Middle Aged; Osteomalacia; Osteoporosis; Phosphorus; Pituitary-Adrenal Function Tests

Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Blood Chemical Analysis; Calcium; Chlorothiazide; Fludrocortisone; Hydrocortisone; Hyperparathyroidism; Hypoadrenocorticism, Familial; Hypoparathyroidism; Hypopituitarism; Natriuresis; Pharmacology; Phosphorus; Pituitary-Adrenal Function Tests; Potassium; Prednisolone; Spironolactone; Urine

Topics: 17-Ketosteroids; Acetylcholine; Adrenal Gland Diseases; Biochemical Phenomena; Biochemistry; Blood Protein Electrophoresis; Capillaries; Epinephrine; Humans; Hyperparathyroidism; Hyperthyroidism; Onychomycosis; Serum Albumin; Serum Globulins; Trichophyton; Urine