| Assay ID | Title | Year | Journal | Article |
|---|
| AID269094 | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation at 10 uM | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. |
| AID242211 | Inhibitory concentration was evaluated for in vitro calcilytic activity against human calcium receptor | 2005 | Bioorganic & medicinal chemistry letters, May-16, Volume: 15, Issue:10
| Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones. |
| AID440445 | Clearance in iv and po dosed rat | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID600278 | Intrinsic clearance in human liver microsomes assessed per mg of protein | 2009 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
| The discovery of novel calcium sensing receptor negative allosteric modulators. |
| AID257322 | Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24
| Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. |
| AID600279 | Intrinsic clearance in rat liver microsomes assessed per mg of protein | 2009 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
| The discovery of novel calcium sensing receptor negative allosteric modulators. |
| AID482482 | Inhibition of CaSR in bovine parathyroid cells assessed as increase in PTH level | 2010 | Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
| Emerging targets in osteoporosis disease modification. |
| AID431502 | Inhibition of human ERG | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists. |
| AID257321 | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | 2005 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 15, Issue:24
| Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. |
| AID269096 | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. |
| AID482480 | Inhibition of human CaSR expressed in HEK293 cells | 2010 | Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11
| Emerging targets in osteoporosis disease modification. |
| AID440282 | Mean residence time in iv and po dosed rat | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID484185 | Increase of serum PTH (1-34) level in Sprague-Dawley rat at 100 mg/kg, po after 30 and 60 mins by ELISA | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
| New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists. |
| AID241701 | Inhibitory concentration against human calcium receptor expressed in HEK 293 cells | 2005 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 15, Issue:6
| 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis. |
| AID431503 | Half life in human | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists. |
| AID440278 | Inhibition of DAT | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID600276 | Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | 2009 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
| The discovery of novel calcium sensing receptor negative allosteric modulators. |
| AID440274 | Antagonist activity at human calcium receptor expressed in HEK293 4.0-7 cells assessed as inhibition of intracellular calcium release by FLIPR assay | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440277 | Inhibition of NET | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440281 | Inhibition of beta2 adrenergic receptor | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440449 | Oral bioavailability in rat | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440275 | Displacement of [3H](2-(2-hydroxyphenyl)-6-methyl-5-(2-methylpropyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone) from human calcium receptor expressed in human HEK293 4.0-7 cells by liquid scintillation counting | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID269095 | Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation at 1 uM | 2006 | Journal of medicinal chemistry, Aug-24, Volume: 49, Issue:17
| N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. |
| AID248866 | Inhibitory concentration for the inhibition of intracellular [Ca2+] release in HEK cells by using FLIPR technology | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. |
| AID440280 | Inhibition of human ERG | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440447 | Volume of distribution at steady state in iv and po dosed rat | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440279 | Inhibition of CYP2D6 | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID241763 | Inhibitory concentration against human Kv11.1 ERG potassium channel | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. |
| AID484186 | Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assay | 2010 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
| New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists. |
| AID440276 | Inhibition of SERT | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID440443 | Half life in iv and po dosed rat | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347412 | qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1346721 | Human CaS receptor (Calcium-sensing receptor) | 2001 | The Journal of pharmacology and experimental therapeutics, Oct, Volume: 299, Issue:1
| Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. |
| AID1346721 | Human CaS receptor (Calcium-sensing receptor) | 2013 | Endocrinology, Mar, Volume: 154, Issue:3
| Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators. |
| AID1346721 | Human CaS receptor (Calcium-sensing receptor) | 2012 | Endocrinology, Mar, Volume: 153, Issue:3
| Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor. |
| AID1346721 | Human CaS receptor (Calcium-sensing receptor) | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. |
| AID1346721 | Human CaS receptor (Calcium-sensing receptor) | 2016 | Cell research, 05, Volume: 26, Issue:5
| Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |