propylthiouracil and Hyperparathyroidism

Topics: Adult; Calcium; Carbimazole; Congenital Hypothyroidism; Dihydrotachysterol; Female; Humans; Hyperparathyroidism; Hyperthyroidism; Hypoparathyroidism; Hypothyroidism; Infant, Newborn; Parathyroid Diseases; Parathyroid Glands; Pregnancy; Pregnancy Complications; Propylthiouracil; Puerperal Disorders; Thyroid Diseases; Thyroxine

Topics: Antithyroid Agents; Female; Humans; Hyperparathyroidism; Middle Aged; Parathyroid Hormone; Parathyroidectomy; Propylthiouracil; Thyrotoxicosis; Thyroxine

Reports of the coexistence of hyperparathyroidism and thyroid disease have raised the issue of a possible etiologic relationship. The present study tests the hypothesis that chronic elevation of thyroid-stimulating hormone (TSH) is related to the development of hyperparathyroidism. Four groups of 60 female rats were treated as follows: group 1, control; group 2, propylthiouracil (PTU) 0.0025%; group 3, PTU 0.0025% plus thyroxine, 5 microg two times per week; and group 4, only thyroxine. The animals' serum calcium, phosphorus, TSH, thyroxine, and parathyroid hormone (PTH) levels were evaluated at 0, 6, 12, and 18 months. Significant elevation of TSH was sustained throughout the 18 months in groups 2 and 3. The PTH levels were also significantly elevated in both group 2 and group 3 animals (P = 0.02). The histopathologic features of the parathyroids were evaluated at 18 months. In the group 2 (PTU only) animals, which had profound hypothyroid, 44% developed parathyroid adenomas. In the group 3 (PTU plus thyroxine) animals, who had mildly elevated TSH levels, 53% developed parathyroid adenomas. These findings are consistent with the hypothesis that prolonged TSH stimulation may lead to hyperparathyroidism in the rat model.

Topics: Adenoma; Animals; Antithyroid Agents; Calcium; Chronic Disease; Disease Models, Animal; Female; Hyperparathyroidism; Hyperplasia; Hypothyroidism; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Phosphorus; Propylthiouracil; Rats; Rats, Sprague-Dawley; Survival Rate; Thyroid Gland; Thyrotropin; Thyroxine

The coexistence of hyperparathyroidism and thyroid tumors and/or chronic thyroiditis has raised the possibility of an etiologic relationship. The present study was designed to test the hypothesis that the chronic elevation of thyroid-stimulating hormone (TSH) is related to the development of hyperparathyroidism. Three groups of 24 rats each were treated for 12 weeks as follows: group 1 received propylthiouracil (PTU) in their deionized water; group 2 received PTU and thyroid hormone to suppress TSH and to serve as a control group for possible direct effects of PTU; and group 3 was not treated at all and served as another control group. At 12 weeks, 95% of group 1 rats (PTU only) showed hyperplasia of the parathyroids with a 30% mean increase in circulating parathormone.

Topics: Administration, Oral; Animals; Calcium; Delayed-Action Preparations; Drug Implants; Female; Hyperparathyroidism; Hyperplasia; Hypothyroidism; Parathyroid Glands; Parathyroid Hormone; Phosphorus; Propylthiouracil; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine

A kindred with a high incidence of hypertrophic cardiomyopathy (HC) was studied to identify the presence of clinical hyperthyroidism. Two and possibly three members with HC had associated hyperthyroidism. In the propositus, clinical, ECG, and vectorcardiographic evidence for HC resolved after treatment of the hyperthyroidism. We hypothesize that the disproportionately high correlation of hyperthyroidism and HC and the resolution found in the propositus after treatment may indicate that antithyroid therapy should be considered in this form of cardiomyopathy.

Topics: Adolescent; Adult; Cardiomyopathies; Female; Genes, Dominant; Humans; Hyperparathyroidism; Pedigree; Propylthiouracil

Topics: Adult; Body Weight; Cortisone; Humans; Hypercalcemia; Hyperparathyroidism; Hyperthyroidism; Iodine Isotopes; Male; Propylthiouracil; Thyroidectomy; Thyroxine