Page last updated: 2024-12-07

4-hydroxy-2',4',6'-trichlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-hydroxy-2',4',6'-trichlorobiphenyl, also known as 4-OH-TCB, is a persistent organic pollutant (POP) that has been widely studied due to its environmental persistence and potential toxicity. It is a chlorinated biphenyl derivative, a group of compounds that have been associated with various health problems, including endocrine disruption, developmental effects, and cancer. The synthesis of 4-OH-TCB typically involves the chlorination of biphenyl followed by hydroxylation. It is a highly lipophilic compound, which contributes to its bioaccumulation in the food chain and persistence in the environment. Research on 4-OH-TCB is primarily focused on understanding its environmental fate, toxicity, and potential health risks. Studies have investigated its bioaccumulation in organisms, its degradation in the environment, and its potential to disrupt endocrine systems. The importance of this compound lies in its potential to pose significant risks to human health and the environment. Understanding its properties and behavior is crucial for developing strategies to mitigate its negative impacts.'

4-hydroxy-2',4',6'-trichlorobiphenyl: do not confuse with the tetrachlorinated compound, also known as 4-OH-TCB (see 4-OH-TCB (tetra)) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID105036
CHEMBL ID79850
CHEBI ID34235
SCHEMBL ID2767670
MeSH IDM0274520

Synonyms (26)

Synonym
BIDD:ER0051
chebi:34235 ,
CHEMBL79850
14962-28-8
2,4,6-trichloro-4'-biphenylol
4-hydroxy-2',4',6'-trichlorobiphenyl
C14189 ,
2',4',6'-trichloro-4-biphenylol
4-biphenylol, 2',4',6'-trichloro-
2',4',6'-trichloro-(1,1'-biphenyl)-4-ol
(1,1'-biphenyl)-4-ol, 2',4',6'-trichloro-
ccris 9183
oh-pcb-30
4-(2,4,6-trichlorophenyl)phenol
03kw6rt30c ,
unii-03kw6rt30c
phenol, 4-phenyl-2',4',6'-trichloro-
2',4',6'-trichloro(1,1'-biphenyl)-4-ol
2',4',6'-trichlorobiphenyl-4-ol
SCHEMBL2767670
LTQJFLVGNGVJCX-UHFFFAOYSA-N
2',4',6'-trichloro[1,1'-biphenyl]-4-ol #
DTXSID7074539
Q27115931
2',4',6'-trichloro-4-biphenylol (oh-pcb-30)
PD015516
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
biphenylsBenzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
trichlorobenzeneAny member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TransthyretinHomo sapiens (human)Concentration0.02000.01000.13800.6000AID161428
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
signal transductionTransthyretinHomo sapiens (human)
purine nucleobase metabolic processTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
hormone activityTransthyretinHomo sapiens (human)
protein bindingTransthyretinHomo sapiens (human)
identical protein bindingTransthyretinHomo sapiens (human)
thyroid hormone bindingTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
extracellular regionTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
azurophil granule lumenTransthyretinHomo sapiens (human)
extracellular exosomeTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID230635KPCB/ K352 ratio of the compound1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161431Thyroxine binding constant on human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161427Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T41986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161428Concentration at which 50% total binding against prealbumin protein occurs1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161430Displacement of [125I]thyroxin from human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's4 (44.44)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]