Compounds > 4-hydroxy-2',4',6'-trichlorobiphenyl
Page last updated: 2024-09-24

4-hydroxy-2',4',6'-trichlorobiphenyl

Description

4-hydroxy-2',4',6'-trichlorobiphenyl: do not confuse with the tetrachlorinated compound, also known as 4-OH-TCB (see 4-OH-TCB (tetra)) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID105036
CHEMBL ID79850
CHEBI ID34235
SCHEMBL ID2767670
MeSH IDM0274520

Synonyms (26)

Synonym
BIDD:ER0051
chebi:34235 ,
CHEMBL79850
14962-28-8
2,4,6-trichloro-4'-biphenylol
4-hydroxy-2',4',6'-trichlorobiphenyl
C14189 ,
2',4',6'-trichloro-4-biphenylol
4-biphenylol, 2',4',6'-trichloro-
2',4',6'-trichloro-(1,1'-biphenyl)-4-ol
(1,1'-biphenyl)-4-ol, 2',4',6'-trichloro-
ccris 9183
oh-pcb-30
4-(2,4,6-trichlorophenyl)phenol
03kw6rt30c ,
unii-03kw6rt30c
phenol, 4-phenyl-2',4',6'-trichloro-
2',4',6'-trichloro(1,1'-biphenyl)-4-ol
2',4',6'-trichlorobiphenyl-4-ol
SCHEMBL2767670
LTQJFLVGNGVJCX-UHFFFAOYSA-N
2',4',6'-trichloro[1,1'-biphenyl]-4-ol #
DTXSID7074539
Q27115931
2',4',6'-trichloro-4-biphenylol (oh-pcb-30)
PD015516

Drug Classes (2)

ClassDescription
biphenylsBenzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
trichlorobenzeneAny member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TransthyretinHomo sapiens (human)Concentration0.02000.01000.13800.6000AID161428
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
signal transductionTransthyretinHomo sapiens (human)
purine nucleobase metabolic processTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
hormone activityTransthyretinHomo sapiens (human)
protein bindingTransthyretinHomo sapiens (human)
identical protein bindingTransthyretinHomo sapiens (human)
thyroid hormone bindingTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
extracellular regionTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
azurophil granule lumenTransthyretinHomo sapiens (human)
extracellular exosomeTransthyretinHomo sapiens (human)
extracellular spaceTransthyretinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID230635KPCB/ K352 ratio of the compound1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161431Thyroxine binding constant on human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161427Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T41986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161428Concentration at which 50% total binding against prealbumin protein occurs1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161430Displacement of [125I]thyroxin from human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's4 (44.44)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
thyroxine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		mitogen
thyroxine[no description available]medium102-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
diphenyl[no description available]medium20aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
3,3',5'-triiodothyronine[no description available]medium10iodothyroninehuman metabolite
2,2',6,6'-tetrachlorobiphenyl[no description available]medium20
3,4,5,3',4',5'-hexachlorobiphenyl[no description available]medium20hexachlorobiphenyl;
trichlorobenzene
kc 400[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]medium20dichlorobenzene;
hydroxybiphenyls
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl[no description available]medium40biphenyls;
tetrachlorobenzene
2,4,6-triiodophenol[no description available]medium10
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
oxytocin[no description available]medium10heterodetic cyclic peptide;
peptide hormone		oxytocic;
vasodilator agent
tamoxifen[no description available]medium20stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
heptanol[no description available]medium10heptanol;
primary alcohol		flavouring agent;
fragrance;
gap junctional intercellular communication inhibitor;
plant metabolite
tetraethylammonium[no description available]medium10quaternary ammonium ion
calcimycin[no description available]medium10benzoxazole
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
fulvestrant[no description available]medium2017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
phytoestrogens[no description available]medium10
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
afimoxifene[no description available]medium10phenols;
tertiary amino compound		antineoplastic agent;
estrogen receptor antagonist;
metabolite
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane[no description available]medium10bisphenol
bay h 4502[no description available]low00biphenyls;
imidazoles
candesartan cilexetil[no description available]low00biphenyls
4-biphenylylacetic acid[no description available]low00biphenyls;
monocarboxylic acid		non-steroidal anti-inflammatory drug
fenbufen[no description available]low004-oxo monocarboxylic acid;
biphenyls		non-steroidal anti-inflammatory drug
3,3'-dichlorobenzidine[no description available]low00biphenyls;
monochlorobenzenes;
organochlorine compound
3,3'-diaminobenzidine[no description available]low00biphenyls;
substituted aniline		histological dye
benzidine[no description available]low00biphenyls;
substituted aniline		carcinogenic agent
4-nitrobiphenyl[no description available]low00biphenyls
dianisidine[no description available]low00biphenyls
2-tolidine[no description available]low00biphenyls
n,n'-diacetylbenzidine[no description available]low00biphenyls
2-amino-4-phenylphenol[no description available]low00biphenyls
4-acetylaminobiphenyl[no description available]low00biphenyls
4-biphenylylacetic acid ethyl ester[no description available]low00biphenyls
brequinar[no description available]low00biphenyls;
monocarboxylic acid;
monofluorobenzenes;
quinolinemonocarboxylic acid		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor;
immunosuppressive agent;
pyrimidine synthesis inhibitor
tasosartan[no description available]low00biphenyls
telmisartan[no description available]low00benzimidazoles;
biphenyls;
carboxybiphenyl		angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic
clobuzarit[no description available]low00biphenyls;
organochlorine compound
magnolol[no description available]low00biphenyls
honokiol[no description available]low00biphenyls
bitertanol[no description available]low00aromatic ether;
biphenyls;
secondary alcohol;
triazoles
isodiospyrin[no description available]low00biphenyls
difenpiramide[no description available]low00biphenyls;
monocarboxylic acid amide;
pyridines		antipyretic;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
2-(4-phenylphenoxy)propanoic acid[no description available]low00biphenyls
dityrosine[no description available]low00biphenyls;
non-proteinogenic alpha-amino acid;
tyrosine derivative		biomarker
4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl[no description available]low00biphenyls;
dichlorobenzene;
sulfone
nitroflurbiprofen[no description available]low00biphenyls;
carboxylic ester;
nitrate ester;
organofluorine compound		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector;
non-steroidal anti-inflammatory drug;
vasodilator agent
olmesartan medoxomil[no description available]low00biphenyls
4'-hydroxyflurbiprofen[no description available]low00biphenyls
dehydrodieugenol[no description available]low00biphenyls
bifeprunox[no description available]low00biphenyls
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamide[no description available]low00anilide fungicide;
biphenyls;
monochlorobenzenes;
pyridinecarboxamide		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
environmental contaminant;
xenobiotic
aucuparin[no description available]low00biphenyls
2-[(3,4-dimethoxyphenyl)methyl]-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole[no description available]low00biphenyls
2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole[no description available]low00biphenyls
(2'-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide)[no description available]low00biphenyls
4-phenylbenzoic acid (propan-2-ylideneamino) ester[no description available]low00biphenyls
N-[[(6-methyl-2-pyridinyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide[no description available]low00biphenyls
4-phenyl-N-(2-propyl-5-tetrazolyl)benzamide[no description available]low00biphenyls
2-[(1-methyl-5-tetrazolyl)thio]-N-(2-phenylphenyl)acetamide[no description available]low00biphenyls
3-phenyl-5-(2-phenylphenyl)-1,2,4-oxadiazole[no description available]low00biphenyls
N-[[methyl-(phenylmethyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide[no description available]low00biphenyls
N-[4-[4-(ethylsulfonylamino)-3-methoxyphenyl]-2-methoxyphenyl]ethanesulfonamide[no description available]low00biphenyls
urb 597[no description available]low00biphenyls
3-(4-phenylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine[no description available]low00biphenyls
ac 55649[no description available]low00biphenyls;
carboxybiphenyl
1-[3-(4-phenylphenoxy)propyl]-1,2,4-triazole[no description available]low00biphenyls
N-[2-(2-phenylphenoxy)ethyl]-2-furancarboxamide[no description available]low00biphenyls
2-(2-phenylanilino)-N-(phenylmethyl)acetamide[no description available]low00biphenyls
4-(2-fluorophenyl)-N-(2-methylbut-3-yn-2-yl)benzamide[no description available]low00biphenyls
5-oxo-3-(4-phenylphenyl)-2H-furan-4-carbonitrile[no description available]low00biphenyls
N-([biphenyl]-2-yl)-3-cyclopentylpropanamide[no description available]low00biphenyls;
cyclopentanes;
secondary carboxamide
1-(4-morpholinyl)-2-(4-phenylphenoxy)-1-propanone[no description available]low00biphenyls
2-(4-morpholinyl)-N-(2-phenylphenyl)propanamide[no description available]low00biphenyls
4-[4-[2-hydroxy-3-(4-morpholinyl)propoxy]phenyl]benzonitrile[no description available]low00biphenyls;
nitrile
3-[4-[(2-hydroxy-5-phenylphenyl)methyl]-1-piperazinyl]propanenitrile[no description available]low00biphenyls
N-(2-methoxyethyl)-4-[4-(2-methoxyethylsulfamoyl)phenyl]benzenesulfonamide[no description available]low00biphenyls
2-phenylbutanoic acid [2-oxo-2-(2-phenylanilino)ethyl] ester[no description available]low00biphenyls
2-(4-benzoyl-1-piperazinyl)-N-(2-phenylphenyl)propanamide[no description available]low00biphenyls
fexaramine[no description available]low00biphenyls
alx 5407[no description available]low00biphenyls
bay 12-9566[no description available]low00biphenyls;
organochlorine compound
sacubitril[no description available]low00biphenyls
biphenyl-indanone a[no description available]low00biphenyls
fimasartan[no description available]low00biphenyls
2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid[no description available]low00biphenyls;
organobromine compound
l-161982[no description available]low00biphenyls
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide[no description available]low001,3,4-oxadiazoles;
benzamides;
biphenyls;
nitrile		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
abt-737[no description available]low00aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide[no description available]low00biphenyls
ly2183240[no description available]low00biphenyls
fluxapyroxad[no description available]low00anilide fungicide;
aromatic amide;
biphenyls;
pyrazoles;
trifluorobenzene		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
(3R,3aS,7R,7aS)-3-[4-[4-(dimethylamino)phenyl]-2-fluorophenyl]-7-methyl-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one[no description available]low00biphenyls
3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide[no description available]low00biphenyls
WWL113[no description available]low00biphenyls
lde225[no description available]low00aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
N-[3-(3-chlorophenyl)phenyl]-1-(3-isoxazolylmethyl)-4-piperidinecarboxamide[no description available]low00biphenyls;
organochlorine compound
N-[3-(3-chlorophenyl)phenyl]-1-(3-oxolanylmethyl)-4-piperidinecarboxamide[no description available]low00biphenyls;
organochlorine compound
4-(4-acetyloxyphenyl)benzoic acid [2-[[2-(2-chloroanilino)-2-oxoethyl]-methylamino]-2-oxoethyl] ester[no description available]low00biphenyls
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide[no description available]low00benzamides;
biphenyls;
cyclopropanes;
dicarboxylic acid diamide		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
tak-875[no description available]low00biphenyls
bms-790052[no description available]low00biphenyls;
carbamate ester;
carboxamide;
imidazoles;
valine derivative		antiviral drug;
nonstructural protein 5A inhibitor
(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol[no description available]low00biphenyls
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine[no description available]low00biphenyls;
thienopyrimidine
ml228 probe[no description available]low001,2,4-triazines;
biphenyls;
pyridines;
secondary amino compound		hypoxia-inducible factor pathway activator
a 769662[no description available]low00biphenyls
1,2,4-trichlorobenzene[no description available]low00trichlorobenzene
2,4,5-trichlorophenoxyacetic acid[no description available]low00chlorophenoxyacetic acid;
trichlorobenzene		defoliant;
phenoxy herbicide;
synthetic auxin
hexachlorophene[no description available]low00bridged diphenyl fungicide;
polyphenol;
trichlorobenzene		acaricide;
antibacterial agent;
antifungal agrochemical;
antiseptic drug
2,4,6-trichloroanisole[no description available]low00monomethoxybenzene;
trichlorobenzene
1,2,3-trichlorobenzene[no description available]low00trichlorobenzene
1,3,5-trichlorobenzene[no description available]low00trichlorobenzene
tetradifon[no description available]low00monochlorobenzenes;
organochlorine acaricide;
sulfone;
trichlorobenzene
pcb 118[no description available]low00dichlorobenzene;
pentachlorobiphenyl;
trichlorobenzene
2,3,3',4,4'-pentachlorobiphenyl[no description available]low00dichlorobenzene;
pentachlorobiphenyl;
trichlorobenzene
2,4,6,2',4',6'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl;
trichlorobenzene
2,3,5,2',3',5'-hexachlorobiphenyl[no description available]low00hexachlorobiphenyl;
trichlorobenzene
2,3,4,5,3',4',5'-heptachlorobiphenyl[no description available]low00heptachlorobiphenyl;
tetrachlorobenzene;
trichlorobenzene
3,4,5,3',4'-pentachlorobiphenyl[no description available]low00pentachlorobiphenyl;
trichlorobenzene
prochloraz[no description available]low00amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic
tetrachlorvinphos[no description available]low00alkenyl phosphate;
dialkyl phosphate;
organochlorine insecticide;
organophosphate insecticide;
trichlorobenzene		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)propan-2-yl]pyrazole-4-carboxamide[no description available]low00aromatic amide;
monocarboxylic acid amide;
organofluorine compound;
pyrazoles;
trichlorobenzene
ConditionIndicatedRelationship StrengthStudiesTrials
Infertility, Female0low10
Pregnancy0low20
Sterility, Female0low10
Sterility, Postpartum0low10
Sub-Fertility, Female0low10
Subfertility, Female0low10