| ID Source | ID |
|---|---|
| PubMed CID | 6620 |
| CHEMBL ID | 2392777 |
| CHEBI ID | 34321 |
| SCHEMBL ID | 35285 |
| Synonym |
|---|
| BIDD:ER0206 |
| 4,4'-propane-2,2-diylbis(2-methylphenol) |
| phenol, 4,4'-(1-methylethylidene)bis[2-methyl- |
| o-cresol, 4,4'-isopropylidenedi- |
| ai3-61721 |
| o-cresol, 4,4'-(2,2-propylene)bis- |
| 4,4'-isopropylidenebis(2-methylphenol) |
| brn 2053755 |
| einecs 201-240-0 |
| phenol, 4,4'-(1-methylethylidene)bis(2-methyl- |
| 4,4'-(1-methylethylidene)bis(2-methylphenol) |
| nsc 408489 |
| dicresylolpropane |
| phenol,4'-(1-methylethylidene)bis[2-methyl- |
| 3,3'-dimethyldian |
| nsc-408489 |
| o-cresol,4'-isopropylidenedi- |
| o-cresol,4'-(2,2-propylene)bis- |
| 2,2-bis(3-methyl-4-hydroxyphenyl)propane |
| 79-97-0 |
| 2,2-bis-(4-hydroxy-3-methylphenyl)propane |
| nonox dcp |
| 4,4'-isopropylidenebis[2-methylphenol] |
| wln: qr b1 dx1&1&r dq c1 |
| nsc408489 |
| 4,4'-isopropylidenedi-o-cresol |
| wln: qr b1 dy1&1r dq c1 |
| 2,2-bis(4-hydroxy-3-methylphenyl)propane |
| 3,3'-dimethylbisphenol a |
| 2,2-bis(4-hydroxy-3-methylphenyl)propane, 97% |
| OPREA1_808602 |
| B1567 , |
| KUC105974N |
| ksc-7-288 |
| 4-[2-(4-hydroxy-3-methylphenyl)propan-2-yl]-2-methylphenol |
| FT-0652040 |
| inchi=1/c17h20o2/c1-11-9-13(5-7-15(11)18)17(3,4)14-6-8-16(19)12(2)10-14/h5-10,18-19h,1-4h3 |
| ymtyztxuzlqusf-uhfffaoysa- |
| AKOS001043955 |
| NCGC00248697-01 |
| NCGC00258108-01 |
| cas-79-97-0 |
| dtxsid8047890 , |
| dtxcid4027866 |
| tox21_200554 |
| hsdb 8092 |
| unii-98817i7xj2 |
| bis-o-cresol a |
| 4-06-00-06751 (beilstein handbook reference) |
| 98817i7xj2 , |
| b 1567 |
| 4-(1-(4-hydroxy-3-methylphenyl)-1-methylethyl)-2-methylphenol |
| 2,2 bis(4-hydroxy-3-methylphenyl)propane |
| 2, 2-bis(3-methyl-4-hydroxyphenyl)propane |
| phenol, 4,4'-(1-methylethylidene)bis(2-methyl)- |
| chebi:34321 , |
| CHEMBL2392777 , |
| 4,4'-(propane-2,2-diyl)bis(2-methylphenol) |
| AB01330395-02 |
| 2,2-bis(4'-hydroxy-3'-methylphenyl)-propane |
| 2.2-bis(3-methyl-4-hydroxyphenyl) propane |
| SCHEMBL35285 |
| W-104256 |
| 4,4'-(1-methyl-ethylidene)bis[2- methyl phenol] |
| 4,4'-(1-methyl-ethylidene)bis[2-methyl phenol] |
| sr-01000596929 |
| SR-01000596929-1 |
| mfcd00002232 |
| CCG-244242 |
| AS-65412 |
| NCGC00248697-02 |
| Q9658055 |
| EN300-17225 |
| AMY8654 |
| A864773 |
| bdbm50523938 |
| bisphenol c 100 microg/ml in methanol |
| CS-0172109 |
| Class | Description |
|---|---|
| bisphenol | By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 52.3233 | 3.1890 | 29.8841 | 59.4836 | AID1224846 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 40.5342 | 0.0060 | 38.0041 | 19,952.5996 | AID1159521; AID1159523 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 24.2039 | 0.0007 | 14.5928 | 83.7951 | AID1259368; AID1259369; AID1259392 |
| AR protein | Homo sapiens (human) | Potency | 11.1069 | 0.0002 | 21.2231 | 8,912.5098 | AID1259243; AID1259247; AID743035; AID743036; AID743042; AID743054; AID743063 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 65.3245 | 0.0133 | 26.9810 | 70.7614 | AID1346978 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 15.2537 | 0.0006 | 57.9133 | 22,387.1992 | AID1259377; AID1259378 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 27.4812 | 0.0010 | 22.6508 | 76.6163 | AID1224838; AID1224839; AID1224893 |
| progesterone receptor | Homo sapiens (human) | Potency | 4.6246 | 0.0004 | 17.9460 | 75.1148 | AID1346795 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 14.8446 | 0.0002 | 14.3764 | 60.0339 | AID720691; AID720692 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 56.1100 | 0.0030 | 41.6115 | 22,387.1992 | AID1159552; AID1159553; AID1159555 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 29.4236 | 0.0008 | 17.5051 | 59.3239 | AID1159527 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.4492 | 0.0015 | 30.6073 | 15,848.9004 | AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 52.3233 | 0.3758 | 27.4851 | 61.6524 | AID743217 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 58.2205 | 0.0054 | 28.0263 | 1,258.9301 | AID1346982 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 35.8278 | 0.0002 | 29.3054 | 16,493.5996 | AID1259244; AID1259248; AID1259383; AID743069; AID743075; AID743078; AID743079 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 46.6332 | 0.0010 | 24.5048 | 61.6448 | AID743215 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.5650 | 0.0010 | 19.4141 | 70.9645 | AID743191 |
| caspase-3 | Homo sapiens (human) | Potency | 65.3245 | 0.0133 | 26.9810 | 70.7614 | AID1346978 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 65.3245 | 0.0017 | 23.8393 | 78.1014 | AID743083 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 41.4904 | 0.0016 | 28.0151 | 77.1139 | AID1224843; AID1224895 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 58.7077 | 0.1434 | 27.6121 | 59.8106 | AID1159516 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 28.7111 | 0.1549 | 17.8702 | 43.6557 | AID1346877 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 52.3233 | 19.7391 | 45.9784 | 64.9432 | AID1159509 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 42.4657 | 0.0578 | 21.1097 | 61.2679 | AID1159526; AID1159528 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 23.1780 | 0.0003 | 23.4451 | 159.6830 | AID743065; AID743067 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.3646 | 0.0006 | 27.2152 | 1,122.0200 | AID743202; AID743219 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 51.8891 | 0.0015 | 57.7890 | 15,848.9004 | AID1259244 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 13.0339 | 0.0023 | 19.5956 | 74.0614 | AID651631; AID720552 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 51.8891 | 0.0015 | 51.7393 | 15,848.9004 | AID1259244 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | IC50 (µMol) | 0.8437 | 0.0000 | 0.7237 | 32.7000 | AID1594506; AID1594508; AID758902 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | EC50 (µMol) | 5.6910 | 0.0000 | 0.5305 | 4.4000 | AID1594507; AID1594509 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID752867 | Inhibition of rabbit skeletal muscle sarco/endoplasmic reticulum calcium ATPase assessed as inhibition of ATP hydrolysis by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Structural requirements for inhibitory effects of bisphenols on the activity of the sarco/endoplasmic reticulum calcium ATPase. |
| AID1594510 | Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalpha degradation by luciferase reporter gene assay relative to untreated control | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. |
| AID758902 | Antagonist activity at human Gal4-ERalpha assessed as inhibition of 17beta-estradiol-induced effect by reporter gene assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist. |
| AID1594509 | Selective estrogen receptor down-regulator activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ERalpha degradation by luciferase reporter gene assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. |
| AID758897 | Antagonist activity at human Gal4-ERbeta assessed as inhibition of 17beta-estradiol-induced effect at 3 uM by reporter gene assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist. |
| AID758903 | Agonist activity at human Gal4-ERalpha at 10 uM by reporter gene assay relative to 17beta-estradiol | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist. |
| AID1594508 | Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcriptional activity by luciferase reporter gene assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. |
| AID1594507 | Agonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as induction of ER-alpha-mediated transcriptional activity by luciferase reporter gene assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. |
| AID758899 | Agonist activity at human Gal4-ERbeta at 10 uM by reporter gene assay relative to 17beta-estradiol | 2013 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14 | Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist. |
| AID1594506 | Binding affinity to GST-tagged human ER alpha ligand-binding domain by TR-FRET assay | 2019 | Bioorganic & medicinal chemistry, 05-15, Volume: 27, Issue:10 | Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||