Angle Class I

Malocclusion in which the mandible and maxilla are anteroposteriorly normal as reflected by the relationship of the first permanent molar (i.e., in neutroclusion), but in which individual teeth are abnormally related to each other.

Synonym
Malocclusion, Angle Class I
Angle Class I

Excerpt	Reference
"Sixteen subjects with Angle Class I malocclusion (median age: 23·4 ± 5·9 years) who had never undergone orthodontic treatment were randomly selected."	( Kageyama, T; Masuda, Y; Murakami, M; Okazaki, R; Takehana, Y; Yamada, K, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	14 (7.04)	23.3326
1990's	30 (15.08)	12.5806
2000's	57 (28.64)	18.1394
2010's	94 (47.24)	28.8240
2020's	4 (2.01)	9.53

Drug	Relationship Strength	Studies	Trials
nickel	medium	24	4
acetaminophen	medium	1	1
caffeine	medium	1	1
gentamicin	low	1	0
2-propanol	low	1	0
ampicillin	low	1	0
isoprene	low	7	0
bisphenol a	low	1	0
zinc oxide	low	1	0
bisphenol a-glycidyl methacrylate	low	1	0
titanium	medium	35	5
calcium sulfate	low	2	0
propiconazole	low	9	0
inositol 3-phosphate	medium	67	2
nitinol	low	2	0
osteoprotegerin	low	1	0
cholecalciferol	low	1	0
phenylephrine hydrochloride	low	36	0
jaw	medium	11	1
vendex	medium	20	1
tetracycline	low	1	0
caseins	low	1	0
transforming growth factor alpha	low	1	0
chondroitin sulfates	low	1	0
exudates	low	4	0

Protein Targets (356)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	7	0	0	7
GLI family zinc finger 3	7	0	0	7
AR protein	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	9	0	0	9
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
activating transcription factor 6	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	5	0	0	5
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lamin isoform A-delta10	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	0	0	6
ATAD5 protein, partial	3	0	0	3
GLS protein	4	0	0	4
Microtubule-associated protein tau	2	0	0	2
Smad3	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
estrogen-related nuclear receptor alpha	7	0	0	7
peroxisome proliferator activated receptor gamma	7	0	0	7
aryl hydrocarbon receptor	5	0	0	5
chromobox protein homolog 1	5	0	0	5
thyroid hormone receptor beta isoform 2	6	0	0	6
peripheral myelin protein 22	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Bile salt export pump	0	3	0	3
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
UDP-glucuronosyltransferase 1-6	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Carbonic anhydrase 9	0	1	0	1
GABA theta subunit	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	3	0	3
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	2	0	0	2
Beta-lactamase	0	0	0	1
acid sphingomyelinase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
farnesoid X nuclear receptor	6	0	0	6
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
geminin	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Luciferase	2	0	0	2
acetylcholinesterase	1	0	0	1
glp-1 receptor, partial	4	0	0	4
GALC protein	2	0	0	2
TDP1 protein	4	0	0	4
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	8	0	0	8
pregnane X nuclear receptor	5	0	0	5
G	1	0	0	1
cytochrome P450 2D6	1	0	0	1
caspase-3	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
GTPase KRas	0	0	1	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Estrogen receptor	0	2	1	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Cellular tumor antigen p53	5	0	0	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Androgen receptor	0	1	0	1
Androgen receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
GTP-binding protein Rheb	0	0	1	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Estrogen receptor beta	0	1	1	2
cytochrome P450 2C9, partial	1	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
TSHR protein	1	0	0	1
67.9K protein	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
IDH1	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Alpha-synuclein	1	1	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
phosphopantetheinyl transferase	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Adenosine receptor A1	0	2	0	3
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	1	0	1
Chain A, Ferritin light chain	2	0	0	2
interleukin 8	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
USP1 protein, partial	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
survival motor neuron protein isoform d	1	0	0	1
60 kDa chaperonin	0	1	0	1
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Vitamin D3 receptor	0	0	1	1
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chymotrypsinogen A	0	1	0	1
thioredoxin reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
pregnane X receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (199)

Protein Targets (356)

Angle Class I

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (199)

Drugs Studied (32)

Protein Targets (356)