Page last updated: 2024-12-05

methyl carbonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Methyl carbonate is a colorless liquid with a sweet odor, synthesized via various methods, including the reaction of methanol with carbon monoxide and oxygen in the presence of a catalyst. It is a versatile compound with various applications: it serves as a solvent, a fuel additive, and a reagent in organic synthesis. Methyl carbonate is considered environmentally friendly due to its low toxicity and biodegradability. Researchers are investigating its potential as a green alternative to traditional solvents and its application in the development of sustainable technologies.'

methyl carbonate: RN given refers to unlabeled parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dimethyl carbonate : A carbonate ester that is carbonic acid in which both hydrogens are replaced by methyl groups. A flammable, colourless liquid (m.p. 2-4degreeC, b.p. 90degreeC) with a characterstic ester-like odour, it is used as a 'green' methylating agent and as a solvent. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID12021
CHEMBL ID3185216
CHEBI ID36596
MeSH IDM0079776

Synonyms (56)

Synonym
CHEBI:36596 ,
ec 210-478-4
ke9j097spn ,
dimethyl carbonate [un1161] [flammable liquid]
unii-ke9j097spn
dimethyl carbonate [un1161] [flammable liquid]
nsc 9371
hsdb 6928
einecs 210-478-4
ai3-14705
un1161
methyl carbonate ((meo)2co)
methyl carbonate
dimethyl carbonate
carbonic acid, dimethyl ester
nsc-9371
nsc9371
wln: 1ovo1
616-38-6
inchi=1/c3h6o3/c1-5-3(4)6-2/h1-2h
dimethyl carbonate, reagentplus(r), 99%
dimethyl carbonate, anhydrous, >=99%
carbonic acid dimethyl ester
AKOS000121888
A833342
NCGC00249139-01
dimethylcarbonate
dtxcid609192
dtxsid9029192 ,
cas-616-38-6
NCGC00257358-01
tox21_303590
tox21_201940
NCGC00259489-01
FT-0623477
dimethyl carbonate [hsdb]
dimethyl carbonate [inci]
d.m.c.
dimethyl carbonate [mi]
dim ethyl carbonate
dimethy carbonate
methoxyketone
un 1161
ch3ocooch3
dimethyl ester of carbonic acid
CHEMBL3185216
F1905-7139
dimethyl carbonate, >=99.9%, acid <10 ppm, h2o <10 ppm
mfcd00008420
dimethyl carbonate, analytical standard
e242
carbonic acid dimethyl ester, 9ci
Q416254
AMY37165
dimethylcarbonate, 99%
carbonic acid,di(methyl-d3) ester (6ci)

Research Excerpts

Overview

Dimethyl carbonate (DMC) is an oxygenated compound which is a good option to reduce soot. The detailed characteristics of soot produced from combustion of hydrocarbon fuels blended with DMC are still lacking.

ExcerptReferenceRelevance
"Dimethyl carbonate (DMC) is an oxygenated compound which is a good option to reduce soot, but the detailed characteristics of soot produced from combustion of hydrocarbon fuels blended with DMC are still lacking."( Soot reduction by addition of dimethyl carbonate in normal and inverse ethylene diffusion flames: Nanostructural evidence.
Liu, D; Paladpokkrong, C; Wang, W; Ying, Y; Zhang, R, 2018
)
1.32
"Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. "( Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model.
Anderson, KL; Anderson, SE; Franko, J; Lukomska, E; Meade, BJ; Munson, AE,
)
1.08
"Dimethyl carbonate (DMC) is a versatile compound that represents an attractive eco-friendly alternative to both methyl halides (or dimethyl sulfate) and phosgene for methylation and carbonylation processes, respectively. "( The chemistry of dimethyl carbonate.
Selva, M; Tundo, P, 2002
)
1.36

Toxicity

ExcerptReferenceRelevance
" The methodology was applied to cell culture models incubated with commercial lithium ion battery (LIB) electrolytes to gain more insight into the potential toxic effects of these compounds."( Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials.
Bornhorst, J; Galla, HJ; Lürenbaum, C; Nowak, S; Schwerdtle, T; Strehlau, J; Weber, T; Winter, M, 2017
)
0.46

Dosage Studied

ExcerptRelevanceReference
" The effects of ionic liquid kinds, temperature, time, and methanol dosage on methanolysis results of PC were examined."( Environmentally benign methanolysis of polycarbonate to recover bisphenol A and dimethyl carbonate in ionic liquids.
Cui, X; Ge, X; Li, Z; Liu, F; Yu, S, 2010
)
0.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
solventA liquid that can dissolve other substances (solutes) without any change in their chemical composition.
reagentA substance used in a chemical reaction to detect, measure, examine, or produce other substances.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
carbonate esterAny carbonate that is carbonic acid in which the hydrogens have been replaced by organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency54.84420.006038.004119,952.5996AID1159521; AID1159523
progesterone receptorHomo sapiens (human)Potency30.63790.000417.946075.1148AID1346795
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency34.37620.001530.607315,848.9004AID1259401
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency27.30600.001723.839378.1014AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (106)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (0.94)18.7374
1990's1 (0.94)18.2507
2000's19 (17.92)29.6817
2010's70 (66.04)24.3611
2020's15 (14.15)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 54.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index54.76 (24.57)
Research Supply Index4.68 (2.92)
Research Growth Index6.32 (4.65)
Search Engine Demand Index84.20 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (54.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (1.87%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other105 (98.13%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]