| Assay ID | Title | Year | Journal | Article |
|---|
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2005 | The Biochemical journal, Feb-01, Volume: 385, Issue:Pt 3
| Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2005 | The Biochemical journal, Feb-01, Volume: 385, Issue:Pt 3
| Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent. |
| AID1798596 | CA Inhibition Assay from Article 10.1016/j.bmcl.2008.06.105: \\Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.\\ | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1798411 | Aromatase Inhibition Assay from Article 10.1021/jm800168s: \\Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.\\ | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. |
| AID1797029 | Carbonic Anhydrase Inhibition Assay from Article 10.1016/s0006-291x(03)00865-9: \\Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates.\\ | 2003 | Biochemical and biophysical research communications, Jun-13, Volume: 305, Issue:4
| Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. |
| AID1798412 | Sulfatase Inhibition Assay from Article 10.1021/jm800168s: \\Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.\\ | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. |
| AID1796988 | Measurement of Dissociation Constant from Article 10.1021/bi047692e: \\First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.\\ | 2005 | Biochemistry, May-10, Volume: 44, Issue:18
| First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. |
| AID1796987 | Carbonic Anhydrase Inhibition Assay from Article 10.1021/bi047692e: \\First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.\\ | 2005 | Biochemistry, May-10, Volume: 44, Issue:18
| First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. |
| AID291838 | Inhibition of steroid sulfatase in JEG3 cell membrane | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID291843 | Inhibition of steroid sulfatase in Wistar rat assessed as reduction of PMSG-stimulated plasma estradiol level at 10 mg/kg, po after 3 hrs | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID1657461 | Inhibition of steroid sulfatase in human JEG3 cell lysates using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis | 2020 | Bioorganic & medicinal chemistry, 04-15, Volume: 28, Issue:8
| A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. |
| AID1124821 | Inhibition of steroid sulfatase in human MCF7 cells assessed as conversion of [3H]E1S to [3H]E1 and [3H]E2 at 1 uM after 5 hrs by liquid scintillation counting | 2014 | Bioorganic & medicinal chemistry, Apr-01, Volume: 22, Issue:7
| Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character. |
| AID1657459 | Inhibition of steroid sulfatase in human JEG3 cells using [3H] E1S as substrate incubated for 20 hrs by scintillation spectrometry analysis | 2020 | Bioorganic & medicinal chemistry, 04-15, Volume: 28, Issue:8
| A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. |
| AID205773 | In vitro inhibition of [6,7-3H]E1S binding to steroid sulfatase in JEG-3 human placental carcinoma cells at 3.3 nM | 2003 | Journal of medicinal chemistry, Jul-17, Volume: 46, Issue:15
| First dual aromatase-steroid sulfatase inhibitors. |
| AID70990 | Compound was evaluated for its percent inhibition against the estrone sulfatase enzyme at a concentration of 5 uM | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID365980 | Inhibition of human cloned CA3 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1299653 | Inhibition of placental microsomal estrone sulfatase (unknown origin) using [3H]-estrone sulphate as substrate | 2016 | European journal of medicinal chemistry, May-23, Volume: 114 | Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review. |
| AID1482698 | Antiproliferative activity against E1S/E1-stimulated human T47D cells assessed as cell viability at 50 to 200 nM measured after 7 days after MTT assay relative to control | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID1299643 | Potency index, ratio of EMATE IC50 to compound IC50 for placental microsomal estrone sulfatase (unknown origin) | 2016 | European journal of medicinal chemistry, May-23, Volume: 114 | Sulfatase inhibitors for recidivist breast cancer treatment: A chemical review. |
| AID1482687 | Inhibition of human placental microsomal STS assessed as formation of E1 preincubated for 30 mins followed by addition of E1S as substrate measured after 20 mins by ELISA | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID365981 | Inhibition of human cloned CA4 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID26348 | pKa value was determined | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID1874970 | Inhibition of human placental cytosolic fraction 17beta-HSD1 at 1 uM using [3H]-E1 as substrate measured after 10 mins in presence of NADH by HPLC method | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID1482686 | Inhibition of 17beta-HSD1 in human T47D cells at 1 uM preincubated for 1 hr followed by addition of [3H]-E1/E1 as substrate measured after 30 mins by HPLC based radio-detection method | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID461812 | Inhibition of steroid sulfatase in human JEG3 cells by scintillation spectrometry | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. |
| AID365989 | Inhibition of human cloned CA14 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID340415 | Inhibition of steroid sulfatase activity in human JEG3 cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. |
| AID1874968 | Inhibition of STS in human T47D cells using [3H]E1S as substrate measured after 24 hrs by HPLC analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID1482704 | Inhibition of 17beta-HSD1 in human T47D cells assessed as [3H]-E2 level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 95.2%) | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID1071646 | Inhibition of steroid sulfatase (unknown origin) | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents. |
| AID365986 | Inhibition of human cloned CA9 catalytic domain by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1874974 | Metabolic stability in mouse liver S9 fraction assessed as intrinsic clearance at 1 uM in presence of NADPH measured upto 60 min by LC-MS/MS analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID1657460 | Inhibition of steroid sulfatase in human JEG3 cell lysates at 10 uM using [3H] E1S as substrate after 1 hr by scintillation spectrometry analysis relative to control | 2020 | Bioorganic & medicinal chemistry, 04-15, Volume: 28, Issue:8
| A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. |
| AID70847 | Compound was evaluated for its inhibitory activity against estrone sulfatase enzyme | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID70816 | Tested for the inhibitory activity against Estrone Sulfatase | 2001 | Bioorganic & medicinal chemistry letters, Dec-03, Volume: 11, Issue:23
| Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. |
| AID1482692 | Inhibition of STS in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1S/E1S as substrate measured after 24 hrs by HPLC based radio-detection method | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID1482695 | Irreversible inhibition of STS in human T47D cells preincubated for 2 hrs followed by compound washout and addition of [3H]-E1S/E1S as substrate measured after 24 hrs by HPLC based radio-detection method | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID1063491 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production administered 1 hr prior to LPS-challenge measured after 24 hrs by EIA | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages. |
| AID1874973 | Metabolic stability in human liver S9 fraction assessed as intrinsic clearance at 1 uM in presence of NADPH measured upto 60 min by LC-MS/MS analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID365985 | Inhibition of human cloned CA7 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1482710 | Inhibition of human placental cytosolic 17beta-HSD2 at 1 uM using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection method | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID291844 | Inhibition of steroid sulfatase in Wistar rat assessed as reduction of PMSG-stimulated plasma estradiol level at 10 mg/kg, po after 24 hrs | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID365979 | Inhibition of human cloned CA2 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1874972 | Metabolic stability in mouse liver S9 fraction assessed as half life at 1 uM in presence of NADPH measured upto 60 min by LC-MS/MS analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID365982 | Inhibition of human cloned CA5A by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID71010 | Inhibition of estrone sulfatase | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID291841 | Inhibition of aromatase in Wistar rat assessed as reduction of PMSG-stimulated plasma estradiol level at 10 mg/kg, po after 3 hrs | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID340414 | Inhibition of aromatase activity in human JEG3 cells | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. |
| AID1063481 | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production administered 1 hr prior to LPS-challenge measured after 24 hrs by Griess assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages. |
| AID1298865 | Inhibition of steroid sulfatase in human JEG-3 cells assessed as [14C]-Estrone formation using [3H]E1S as substrate | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors. |
| AID71011 | Inhibitory activity against estrone sulfatase at 0.25 uM (initial screening) | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID461809 | Inhibition of aromatase in human JEG3 cells by scintillation spectrometry | 2010 | Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
| Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. |
| AID291824 | Inhibition of Estrone sulfatase in human placental microsome | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. |
| AID1895185 | Inhibition of lysosome sulfatase (unknown origin) assessed as reduction in fluorescence intensity using 2-(2-Morpholinoethyl)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-benzo[de]-isoquinoline-1,3(2H)-dione as s | 2021 | Journal of medicinal chemistry, 06-24, Volume: 64, Issue:12
| New Protocol-Guided Exploitation of a Lysosomal Sulfatase Inhibitor to Suppress Cell Growth in Glioblastoma Multiforme. |
| AID365983 | Inhibition of human cloned CA5B by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1482709 | Inhibition of human placental cytosolic 17beta-HSD1 at 1 uM using [3H]-E1/E1 substrate and NADH after 10 mins by HPLC based radio-detection method | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID365988 | Inhibition of mouse CA13 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID365987 | Inhibition of human cloned CA12 catalytic domain by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID365978 | Inhibition of human cloned CA1 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1874969 | Irreversible inhibition of STS in human T47D cells using [3H]E1S as substrate measured after 24 hrs by HPLC analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID1482702 | Inhibition of 17beta-HSD1 in human T47D cells assessed as [3H]-E1 level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 0.9%) | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID623100 | Inhibition of steroid sulfatase in human intact MCF7 cells | 2011 | Bioorganic & medicinal chemistry, Oct-15, Volume: 19, Issue:20
| Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives. |
| AID291842 | Inhibition of aromatase in Wistar rat assessed as reduction of PMSG-stimulated plasma estradiol level at 10 mg/kg, po after 24 hrs | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID1657462 | Antiproliferative activity against human T47D cells assessed as reduction in cell proliferation measured after 5 days in presence of estradiol sulfate by crystal violet staining based assay | 2020 | Bioorganic & medicinal chemistry, 04-15, Volume: 28, Issue:8
| A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. |
| AID1855807 | Inhibition of STS in human placental microsomes | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | An overview on Estrogen receptors signaling and its ligands in breast cancer. |
| AID365984 | Inhibition of human cloned CA6 by stopped-flow CO2 hydration method | 2008 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 18, Issue:15
| Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. |
| AID1903904 | Inhibition of STS in human MCF7 cells using [3H]E1S as substrate incubated for 20 hrs by radioisotope cellular assay | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID19659 | Partition coefficient (logP) | 2002 | Bioorganic & medicinal chemistry letters, May-20, Volume: 12, Issue:10
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
| AID1903902 | Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]E1S as substrate at 10 nM incubated for 20 hrs by radioisotope cellular assay relative to control | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID1903903 | Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]E1S as substrate at 1 nM incubated for 20 hrs by radioisotope cellular assay relative to control | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID291837 | Inhibition of aromatase in JEG3 cell membrane | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15
| Dual aromatase-steroid sulfatase inhibitors. |
| AID1874971 | Metabolic stability in human liver S9 fraction assessed as half life at 1 uM in presence of NADPH measured upto 60 min by LC-MS/MS analysis | 2022 | Journal of medicinal chemistry, 09-08, Volume: 65, Issue:17
| Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. |
| AID1482700 | Inhibition of STS in human T47D cells assessed as [3H]-E1S level at 200 nM after 48 hrs by HPLC based radio-detection method (Rvb = 3.9%) | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
| First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases. |
| AID644202 | Irreversible inhibition of steroid sulfatase in human intact MCF7 cells | 2012 | Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4
| 17β-Arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase. |
| AID47745 | Compound was tested for inhibition of human carbonic anhydrase (hCA II) | 2003 | Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
| Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. |
| AID1903873 | Inhibition of STS in human MCF7 cells assessed as residual enzyme activity using [3H]E1S as substrate at 100 nM incubated for 20 hrs by radioisotope cellular assay relative to control | 2022 | Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6
| Development of Sulfamoylated 4-(1-Phenyl-1 |
| AID19447 | Partition coefficient (logP) | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. |
| AID1347411 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |