Compounds > 2,5-bis(hydroxymethyl)furan
Page last updated: 2024-11-06

2,5-bis(hydroxymethyl)furan

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,5-bis(hydroxymethyl)furan, also known as 2,5-furandicarboxaldehyde, is a potential platform chemical derived from biomass. It is a colorless crystalline solid with a melting point of 118-120 °C. The compound can be synthesized through various methods, including the reduction of 2,5-furandicarboxylic acid, a readily available product from the dehydration of biomass-derived sugars. 2,5-bis(hydroxymethyl)furan holds significant potential as a building block for various polymers, resins, and pharmaceuticals. Its importance lies in its renewable origin and its ability to replace petroleum-based feedstocks. Researchers are exploring its potential applications in the synthesis of bio-based polymers, such as polyesters and polyamides. Due to its promising properties and its sustainable nature, 2,5-bis(hydroxymethyl)furan is actively studied for its potential to contribute to a more environmentally friendly and sustainable chemical industry.'

2,5-dihydroxymethylfuran: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID74663
CHEMBL ID4303433
CHEBI ID59984
SCHEMBL ID183551
MeSH IDM0157760

Synonyms (60)

Synonym
nsc-40737
nsc40737
1883-75-6
2,5-furandimethanol ,
nsc-524614
nsc524614
inchi=1/c6h8o3/c7-3-5-1-2-6(4-8)9-5/h1-2,7-8h,3-4h
furan-2,5-diyldimethanol
EC-000.1543
nsc 40737
[5-(hydroxymethyl)furan-2-yl]methanol
5-(hydroxymethyl)-furfuryl alcohol
2,5-bis-hydroxymethylfuran
2,5-di(hydroxymethyl)furan
2,5-furanylmethanol
2,5-bis(hydroxymethyl)furan
CHEBI:59984 ,
(furan-2,5-diyl)dimethanol
5-(hydroxymethyl)furfuryl alcohol
2,5-bis(hydroxymethyl)furan; 2,5-di(hydroxymethyl)furan; 5-(hydroxymethyl)-furfuryl alcohol
A4161
AKOS006282605
2,5-dihydroxymethyl-furane
5-hydroxymethylfurfuryl alcohol
C20443
4xe4jyn4g7 ,
unii-4xe4jyn4g7
einecs 217-544-1
nsc 524614
GEO-02495
FT-0633892
AM20090102
EPITOPE ID:136041
5-(hydroxymethyl)furfurylalcohol
2,5-bishydroxymethylfuran
(5-hydroxymethylfuran-2-yl)methanol
furan-2,5-dimethanol
2,5-dihydroxymethylfuran
2,5-bis-(hydroxymethyl)furan
SCHEMBL183551
[5-(hydroxymethyl)-2-furyl]methanol
DTXSID2062036
mfcd00003253
SY030052
2,5-di-(hydroxymethyl)furan
W-200189
TS-01680
AC-22969
2,5-bis-(hydroxymethyl)-furane
CS-W018568
Q4596786
BCP14976
CHEMBL4303433
furan 2,5-dimethanol
SB60896
HY-W017782
2,5-bis(hydroxylmethyl)furan
farez 6305
EN300-85888
PD053824
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
furansCompounds containing at least one furan ring.
diolA compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (6.67)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's7 (46.67)24.3611
2020's6 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.51 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index5.61 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.110aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
bisphenol a
4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.		2.2510bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
furaldehyde
Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.		3.96110aldehyde;
furans		Maillard reaction product;
metabolite
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.110iron group element atom;
platinum group metal atom
2,5-diformylfuran
2,5-diformylfuran: structure in first source. 2,5-diformylfuran : A member of the class of furans carrying two formyl substituents at positions 2 and 5.		2.1510arenecarbaldehyde;
dialdehyde;
furans
glucuronic acid
Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.		2.1710D-glucuronic acidalgal metabolite
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		1.9710chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
5-hydroxymethylfurfural
5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.		3.96110arenecarbaldehyde;
furans;
primary alcohol		indicator;
Maillard reaction product
carnosine
polaprezinc: stimulates bone growth		1.9710amino acid zwitterion;
dipeptide		anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.610glycoside
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials