Page last updated: 2024-12-05

gamma-glycidoxypropyltrimethoxysilane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Gamma-glycidoxypropyltrimethoxysilane (GGPS) is an organosilicon compound with a glycidoxypropyl group and three methoxy groups attached to a silicon atom. It is a colorless liquid that is soluble in organic solvents but insoluble in water. GGPS is used as a coupling agent in various industrial applications, such as adhesives, sealants, and composites. It is also used as a modifier for polymers and resins. GGPS is synthesized by reacting trimethoxysilane with glycidol in the presence of a catalyst. It is a versatile compound that can be used to improve the properties of materials, such as adhesion, strength, and durability. GGPS is studied for its potential applications in various fields, including materials science, biomedical engineering, and environmental science.'

3-glycidyloxypropyltrimethoxysilane: used to immobilize carbonic anhydrase into mesoporous supports; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID17317
CHEMBL ID2140162
SCHEMBL ID27615
MeSH IDM0118148

Synonyms (121)

Synonym
einecs 219-784-2
(3-(glycidyloxy)propyl)trimethoxysilane
gamma-glycidoxypropyltrimethoxysilane ,
ai3-52752
(3-(2,3-epoxypropoxy)propyl)trimethoxysilane
silane, (3-(2,3-epoxypropoxy)propyl)trimethoxy-
glycidoxypropyltrimethyoxysilane, gamma-
silane, trimethoxy(3-(oxiranylmethoxy)propyl)-
nsc 93590
brn 4308125
ccris 3044
3-(trimethoxysilyl)propyl glycidyl ether
((3-(trimethoxysilyl)propoxy)methyl)oxirane
silicone a-187
3-(2,3-epoxypropoxy)propyltrimethoxysilane
silane, 3-(2,3-epoxypropoxy)propyltrimethoxy-
c9h20o5si
AKOS008901332
silane, trimethoxy[3-(oxiranylmethoxy)propyl]-
silane, [3-(2,3-epoxypropoxy)propyl]trimethoxy-
[.gamma.-(glycidyloxy)propyl]trimethoxysilane
silan a 187
glycidyl 3-(trimethoxysilyl)propyl ether
1-(glycidyloxy)-3-(trimethoxysilyl)propane
[[3-(trimethoxysilyl)propoxy]methyl]oxirane
2530-83-8
glycidyloxypropyltrimethoxysilane
union carbide a-187
silicone kbm 403
nsc-93590
wln: t3otj b1o3-si-o1&o1&o1
nsc93590
silane,3-epoxypropoxy)propyl]trimethoxy-
a 187
glycidoxypropyltrimethoxysilane
[3-(glycidyloxy)propyl]trimethoxysilane
.gamma.-[(glycidoxypropyl)trimethoxy]silane
nuca 187
z 6040
(3-glycidoxypropyl)trimethoxysilane
y 4087
[3-(2,3-epoxypropoxy)propyl]trimethoxysilane
kbm 430
silane a 187
silane z 6040
silane-y-4087
.gamma.-glycidoxypropyltrimethoxysilane
(.gamma.-glycidoxypropyl)trimethoxysilane
kbm 403
.alpha.-glycidoxypropyltrimethoxysilane
silicone a 187
dz 6040
(3-glycidyloxypropyl)trimethoxysilane, >=98%
(3-glycidyloxypropyl)trimethoxysilane, >=97% (gc)
NCGC00164370-01
trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane
glymo
trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane
G0210
3-glycidyloxypropyltrimethoxysilane
glycidyl 3-trimethoxysilylpropyl ether
gopts
NCGC00164370-02
3-glycidoxypropyltrimethoxysilane
ec 219-784-2
unii-5k9x9x899r
5k9x9x899r ,
oxirane, 2-((3-(trimethoxysilyl)propoxy)methyl)-
tox21_303288
dtxcid507489
dtxsid5027489 ,
cas-2530-83-8
NCGC00257095-01
NCGC00259221-01
tox21_201672
A817773
trimethoxy-[3-(2-oxiranylmethoxy)propyl]silane
68611-45-0
einecs 247-194-5
((2,3-epoxypropoxy)propyl)trimethoxysilane
25704-87-4
FT-0615768
S09160
(3-glycidoxypropyl)trimethoxy-silane
trimethoxysilylpropylglycidyl-ether
gamma-glycidoxypropyl-trimethoxysilane
gamma-glycidyloxypropyltrimethoxysilane
3-glycidoxypropyltrimethoxy-silane
glycidoxypropyl-trimethoxysilane
3-glycidoxy propyl trimethoxysilane
SCHEMBL27615
epoxirane
trimethoxy(3-(oxiran-2-ylmethoxy)propyl)silane
gamma-glycidoxypropyl trimethoxysilane
CHEMBL2140162
silane, 3(glycidoxy)propyl trimethoxy-
trimethoxy[3-(2-oxiranylmethoxy)propyl]silane #
dow corning z-6040
dynasylan glymo
cg6720
prosil 5136
silane coupler kh-560
mfcd00005144
silane, trimethoxy[(oxiranylmethoxy)propyl]-
3-glycidoxy propyl trimethoxy silane
CS-0132309
(3-glycidyloxypropyl)trimethoxysilane
J-015924
(3- glycidoxypropyl)trimethoxysilane
AS-14542
D78181
3-glycidoxypropyltrimethoxy silane
Q27262482
glycidyl cage mixture
3-(2,3-epoxy propoxy) propyltrimethoxysilane
(3-glycidoxypropyl)trimethoxysilane, 97%
3-(2, 3-epoxypropoxy)propyltrimethoxysilane
3-glycidoxypropyltrimethoxysilane glycidoxypropyltrimethoxysilane epoxy functional silane
3-glycidoxypropyl trimethoxysilane
56325-93-0
trimethoxy({3-[(oxiran-2-yl)methoxy]propyl})silane

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"Chitosan microspheres can address challenges associated with poor bioavailability or unsustained drug release when used as drug delivery systems thanks to their mucoadhesiveness, which allows the drug dosage to be retained in the gastrointestinal track for extended periods."( Characterization and degradation study of chitosan-siloxane hybrid microspheres synthesized using a microfluidic approach.
Cruz-Neves, S; Hayakawa, S; Miyazaki, T; Shirosaki, Y, 2017
)
0.46

Dosage Studied

ExcerptRelevanceReference
"Chitosan microspheres can address challenges associated with poor bioavailability or unsustained drug release when used as drug delivery systems thanks to their mucoadhesiveness, which allows the drug dosage to be retained in the gastrointestinal track for extended periods."( Characterization and degradation study of chitosan-siloxane hybrid microspheres synthesized using a microfluidic approach.
Cruz-Neves, S; Hayakawa, S; Miyazaki, T; Shirosaki, Y, 2017
)
0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency43.64123.189029.884159.4836AID1224846
RAR-related orphan receptor gammaMus musculus (house mouse)Potency35.85580.006038.004119,952.5996AID1159521; AID1159523
AR proteinHomo sapiens (human)Potency10.78230.000221.22318,912.5098AID1259243
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency42.79580.003041.611522,387.1992AID1159552; AID1159553; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency37.44470.001530.607315,848.9004AID1224841; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency28.79360.375827.485161.6524AID743217; AID743220
estrogen nuclear receptor alphaHomo sapiens (human)Potency36.77100.000229.305416,493.5996AID743069; AID743075; AID743079
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency8.70760.001024.504861.6448AID743212
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency43.64120.001019.414170.9645AID743094
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency48.55770.001723.839378.1014AID743083
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency24.541219.739145.978464.9432AID1159509
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency39.81070.015823.527344.6684AID651778
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (50)

Processvia Protein(s)Taxonomy
negative regulation of cytokine production involved in inflammatory responsePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of reactive oxygen species biosynthetic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of hepatocyte apoptotic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of signaling receptor activityPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of ATP biosynthetic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of transformation of host cell by virusPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
response to hypoxiaPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
gluconeogenesisPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
heart developmentPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
response to nutrientPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
epidermis developmentPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
cellular response to starvationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
regulation of cellular ketone metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of macrophage derived foam cell differentiationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of cholesterol storagePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of sequestering of triglyceridePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
regulation of fatty acid metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
intracellular receptor signaling pathwayPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of fatty acid beta-oxidationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of appetitePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
response to insulinPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
circadian regulation of gene expressionPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
behavioral response to nicotinePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
wound healingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
lipoprotein metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
regulation of circadian rhythmPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
steroid hormone mediated signaling pathwayPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
response to ethanolPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of gluconeogenesisPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of blood pressurePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of glycolytic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of DNA-templated transcriptionPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
nitric oxide metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of fatty acid oxidationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of lipid biosynthetic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of inflammatory responsePeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of cell growth involved in cardiac muscle cell developmentPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
enamel mineralizationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
cellular response to fructose stimulusPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of miRNA transcriptionPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
negative regulation of leukocyte cell-cell adhesionPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
regulation of fatty acid transportPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
hormone-mediated signaling pathwayPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
fatty acid metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
positive regulation of fatty acid metabolic processPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
cell differentiationPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (23)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription activator activityPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
transcription coactivator bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription factor activityPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
nuclear steroid receptor activityPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
nuclear receptor activityPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
protein bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
zinc ion bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
lipid bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
phosphatase bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
protein domain specific bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
mitogen-activated protein kinase kinase kinase bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
ubiquitin conjugating enzyme bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
sequence-specific DNA bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
protein-containing complex bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
NFAT protein bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
MDM2/MDM4 family protein bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
DNA-binding transcription factor bindingPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
nucleusPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
nucleoplasmPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
chromatinPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
nucleusPeroxisome proliferator-activated receptor alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (87)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (2.30)18.7374
1990's3 (3.45)18.2507
2000's26 (29.89)29.6817
2010's48 (55.17)24.3611
2020's8 (9.20)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.41 (24.57)
Research Supply Index4.49 (2.92)
Research Growth Index5.31 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other87 (98.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]