positive regulation of integrin biosynthetic process

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. [GOC:go_curators]

Positive regulation of integrin biosynthetic process refers to the cellular mechanisms that enhance the production and assembly of integrins. Integrins are transmembrane receptors that play a crucial role in cell adhesion, migration, and signaling. The process involves a complex interplay of gene expression, protein synthesis, post-translational modifications, and protein trafficking. Here's a detailed breakdown:

**Gene Transcription and mRNA Processing:**
* **Transcriptional activators:** Specific transcription factors bind to regulatory elements in the promoters of integrin genes, stimulating the transcription of integrin mRNA.
* **mRNA stability and translation:** Mechanisms like microRNAs and RNA-binding proteins can regulate the stability and translation of integrin mRNA, influencing the level of integrin protein synthesis.

**Protein Synthesis and Folding:**
* **Ribosomal translation:** Integrin protein subunits (alpha and beta) are synthesized on ribosomes in the cytoplasm.
* **Chaperone proteins:** Molecular chaperones assist in the proper folding and assembly of integrin subunits, ensuring their functional integrity.

**Post-translational Modifications:**
* **Glycosylation:** Specific sugar moieties are added to integrin subunits, contributing to their stability and ligand binding affinity.
* **Phosphorylation:** Phosphorylation events on integrin subunits can regulate their interactions with other proteins and influence their signaling activity.

**Protein Trafficking:**
* **ER and Golgi apparatus:** Newly synthesized integrin subunits are transported through the endoplasmic reticulum (ER) and Golgi apparatus, where they undergo further modifications and sorting.
* **Transport vesicles:** Integrin subunits are packaged into transport vesicles that bud off from the Golgi and deliver them to the plasma membrane.

**Assembly and Activation:**
* **Heterodimerization:** Alpha and beta subunits associate to form heterodimeric integrin molecules.
* **Activation:** Integrins are often inactive in their resting state. Specific signaling events, such as engagement with extracellular matrix proteins, can activate integrins, enabling them to bind ligands and initiate downstream signaling cascades.

The regulation of integrin biosynthesis is crucial for maintaining cellular function and responding to dynamic environmental cues. Dysregulation of this process can contribute to developmental defects, diseases like cancer and fibrosis, and impaired wound healing.'
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Proteins (1)

Compounds (97)