Cretinism

Synonym
Fetal Iodine Deficiency Disorder
Cretinism
Myxedema, Congenital
Endemic Cretinism

Excerpt	Reference
"Neurological cretinism is common in this population."	( Eastman, CJ; Maberly, GF, 1976)
"Endemic cretinism is still present in an endemic goiter area of the central Apennines (Montefeltro) (goiter prevalence 55%; mean urinary iodine level 39 micrograms/g creatinine)."	( Andreani, M; Antonelli, A; Baschieri, L; Bertoni, F; Donati, L; Filippi, T; Gasperini, L; Moscogiuri, D; Neri, S; Venturi, S, 1992)
"Endemic cretinism is the most severe manifestation of dietary iodine deficiency."	( Boyages, SC; Collins, JK; Eastman, CJ; Halpern, JP; Maberly, GF; Morris, JG, 1991)
"Cretinism is the most severe manifestation of iodine deficiency disorders found in areas where iodine intake is greatly reduced."	( Escobar del Rey, F; Morreale de Escobar, G; Obregon, MJ, 1987)
"Endemic goitre and cretinism are still a public health problem in China."	( An, OY; Hershman, JM; Pang, XP; Su, TS, 1988)
"Myxoedematous endemic cretinism is prevalent in African goitre endemies."	( Dumont, JE; Golstein, J; Goyens, P; Nsombola, B; Vis, H, 1987)
"Neurological endemic cretinism is highly prevalent in severe endemic goiter areas."	( Abdelmoumene, N; Ait Hammou, N; Benmiloud, M, 1985)
"Endemic goiter and cretinism are the most typical examples."	( Hedinger, C, 1981)
"Endemic cretinism is a distinctive and easily identifiable clinical entity and is an important indicator of the severity of iodine deficiency in a community."	( Gyatso, TR; Pulger, T; Rai, B; Rai, BM; Sankar, G; Sankar, R, 1993)
"Myxedematous cretinism is paradoxical in showing more severe hypothyroidism and growth failure, yet better intellectual, motor, and hearing function; these observations implicate a second independent factor in its pathogenesis."	( DeLong, GR, 1993)
"Endemic cretinism is the severe and irreversible neurological consequence of iodine deficiency during fetal and neonatal life."	( Cavaliere, R; Chiovato, L; Montanelli, L; Pinchera, A; Santini, F; Vitti, P, 1998)
"Cretinism is a disease characterized by neurological defects associated with severe iodine deficiency."	( Chai, ZF; Hou, XL; Li, YF; Liu, NQ; Liu, PS; Wang, ZH; Xu, Q; Zhao, ZY; Zhu, L, 2001)
"Endemic cretinism is now included in the spectrum of the effects of iodine deficiency in a population termed the 'iodine deficiency disorders (IDDs)', which also includes a wide range of lesser degrees of cognitive defect that can be prevented by the correction of iodine deficiency."	( Chen, ZP; Hetzel, BS, 2010)
"Endemic cretinism is characterised by multiple neurological defects including deaf-mutism, diplegia, squint, and mental deficiency."	( Buttfield, IH; Hetzel, BS; Pharoah, P, 2012)
"Endemic cretinism is the most severe manifestation among the iodine deficiency-related disorders."	( Dunay, IR; French, T; Glas, A; He, Y; Li, B; Li, F; Li, J; Liu, L; Meng, F; Osbelt, L; Ren, B; Schott, BH; Schüler, T; Shen, H; Steffen, J; Strowig, T; Zhang, X; Zhang, Z; Zhou, Z, 2022)

Excerpt	Reference
"Endemic cretinism has disappeared completely."	( Abelin, T; Bürgi, H; Hasler, P; Selz, B; Supersaxo, Z; Wespi, HJ, 1991)
"Cretinism has not yet appeared among the progeny of the population injected with iodized oil but several instances have appeared in control groups."	( Fierro-Benitez, R; Kevany, J; Pretell, EA; Stanbury, JB, 1969)

Excerpt	Reference
"Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied."	( Keesey, RR; Schwark, WS, 1975)
"Contrasting clinical pictures of cretinism, which appeared related to age and previous treatment were found with a spectrum ranging from predominantly myxoedematous in the youngest to predominantly neurological in the 16 year old male."	( Das, SC; Egbuta, JO; Isichei, UP, 1990)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	696 (36.79)	23.3326
1990's	322 (17.02)	12.5806
2000's	352 (18.60)	18.1394
2010's	381 (20.14)	28.8240
2020's	141 (7.45)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
adenine	low	2	0
bromide	low	2	0
1-butanol	low	1	0
carnitine	low	1	0
choline	low	1	0
3-hydroxybutyric acid	low	1	0
creatine	low	1	0
lactic acid	low	1	0
iodine	medium	423	10
methanol	low	1	0
inositol	low	1	0
niacinamide	medium	1	1
niacin	low	1	0
nitrates	low	3	0
nitrites	low	1	0
palmitic acid	low	1	0
thiamine	low	1	0
uric acid	low	2	0
1-anilino-8-naphthalenesulfonate	low	2	0
phenytoin	low	3	0
theophylline	low	1	0
amiodarone	low	4	0
atrazine	low	1	0
betaxolol	low	1	0
carbamazepine	low	1	0
clonidine	low	1	0
flumazenil	low	2	0
imipramine	low	1	0
2-propanol	low	1	0
isoxsuprine	low	1	0
methylphenidate	low	1	0
apnea	low	2	0
pargyline	low	1	0
phenobarbital	low	2	0
potassium iodide	low	11	0
prazosin	low	1	0
propranolol	low	2	0
sodium iodide	low	7	0
succinylcholine	low	1	0
thalidomide	low	1	0
corticosterone	low	2	0
prednisolone	low	3	0
reserpine	low	1	0
thymidine	low	1	0
3,3',5-triiodothyroacetic acid	low	3	0
hydroxyproline	low	3	0
thyroxine	medium	1,129	35
aldosterone	low	3	0
prednisone	low	1	0
triiodothyronine	medium	252	10
alanine	low	2	0
chloramphenicol	low	1	0
glutamine	low	1	0
cyanides	low	1	0
sucrose	low	1	0
methyltestosterone	low	1	0
tetrabenazine	low	1	0
levodopa	low	3	0
tyrosine	low	19	0
leucine	low	1	0
methionine	low	2	0
phenylalanine	low	12	0
desoxycorticosterone	low	1	0
cycloheximide	low	2	0
17-alpha-hydroxyprogesterone	low	2	0
cytarabine	low	1	0
histidine	low	3	0
valine	low	1	0
threonine	low	1	0
isoleucine	low	2	0
arginine	low	8	0
trichloroacetic acid	low	1	0
bisphenol a	low	1	0
n-vinyl-2-pyrrolidinone	low	2	0
diethylhexyl phthalate	low	1	0
dextrothyroxine	low	1	0
4-tert-octylphenol	low	1	0
ephedrine	low	1	0
diiodotyrosine	low	13	0
thiocyanate	low	5	0
azacitidine	low	1	0
betamethasone	low	1	0
limestone	low	1	0
hematoxylin	low	1	0
medroxyprogesterone	low	1	0
malondialdehyde	low	2	0
eosine yellowish-(ys)	low	1	0
ethylnitrosourea	low	2	0
zinc oxide	low	1	0
d-alpha tocopherol	low	1	0
selenomethionine	low	1	0
sabinene	low	1	0
dithiothreitol	low	1	0
mono-(2-ethylhexyl)phthalate	low	1	0
silver	low	1	0
technetium	low	17	0
gold	low	1	0
perchloric acid	low	2	0
sodium nitrate	low	1	0
barium sulfate	low	1	0
fluorine	low	1	0
galactose	low	1	0
chlorine dioxide	low	1	0
sodium selenite	low	1	0
danazol	low	1	0
iodine	medium	75	1
carbimazole	low	1	0
bromocriptine	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
fludrocortisone	low	1	0
glutamic acid	low	1	0
s-adenosylmethionine	low	2	0
etoposide	low	1	0
dobutamine	low	1	0
chlorodiphenyl (54% chlorine)	low	1	0
dihydroalprenolol	low	1	0
fomesafen	low	3	0
quinpirole	low	1	0
atomoxetine hydrochloride	low	1	0
perfluorobutane sulfonate	low	1	0
zoledronic acid	low	1	0
fibrinogen	low	1	0
homocysteine	low	2	0
cobalt	low	1	0
cyanates	low	1	0
pyridinoline	low	1	0
deoxypyridinoline	medium	1	1
3,3'-diiodothyronine	low	1	0
3,5-dimethyl-3'-isopropyl-l-thyronine	low	1	0
deoxyglucose	low	1	0
perchlorate	low	5	0
methotrexate	low	1	0
bis(2,4,6-trichlorophenyl)oxalate	low	1	0
thyroxine, triiodothyronine drug combination	medium	2	1
angiotensin ii	low	2	0
cortisone	low	2	0
povidone-iodine	low	7	0
s-adenosylhomocysteine	low	1	0
glycogen	low	5	0
glucosamine	low	1	0
oxytocin	low	1	0
monoiodotyrosine	low	16	0
inositol 3-phosphate	low	3	0
retinol	low	2	0
diethylstilbestrol	low	2	0
decitabine	low	1	0
riboflavin	low	2	0
potassium perchlorate	low	5	0
sodium perchlorate	low	5	0
glycosides	low	2	0
isomethyleugenol	low	1	0
flavin-adenine dinucleotide	low	1	0
arginine vasopressin	low	1	0
propylthiouracil	low	44	0
mercaptopurine	low	1	0
methylthiouracil	low	1	0
phenylthiourea	low	3	0
thiouracil	low	7	0
methimazole	low	27	0
ethylenethiourea	low	1	0
thiourea	low	3	0
D-fructopyranose	low	1	0
tamoxifen	low	1	0
pica	low	1	0
lithium	low	1	0
nitrogen dioxide	low	1	0
3,3'-diiodothyronine-4-sulfate	low	1	0
17-ketosteroids	low	2	0
cathepsin g	low	1	0
myelin basic protein	low	1	0
bilirubin	low	5	0
calcitriol	medium	1	1
vitamin k semiquinone radical	low	1	0
vitamin d 2	medium	2	1
mivacurium	low	1	0
phenylephrine hydrochloride	low	3	0
morphine	low	2	0
deamino arginine vasopressin	low	1	0
lysophosphatidylcholines	low	1	0
cysteine	low	2	0
thyronines	low	6	0
phosphorus	medium	5	1
heroin	low	1	0
25-hydroxyvitamin d 2	medium	2	1
selenium	low	27	0
selenocysteine	low	1	0
oxalates	low	1	0
simethicone	low	1	0
24,25-dihydroxyvitamin d 3	medium	1	1
1,25-dihydroxyergocalciferol	low	1	0
chlorhexidine	low	2	0
amoxicillin-potassium clavulanate combination	low	1	0
pentagastrin	low	1	0
lactulose	low	1	0
pituitrin	low	6	0
enerbol	low	1	0
dihydrotachysterol	low	1	0
atrial natriuretic factor	low	1	0
hes1 protein, human	low	2	0
glucagon	low	1	0
glucagon-like peptide 1	low	1	0
phosphatidylcholines	low	3	0
compound w	low	1	0
bucladesine	low	1	0
potassium iodate	low	2	0
sodium iodate	low	1	0
sodium pertechnetate tc 99m	medium	35	1
sodium ethylxanthate	low	1	0
triiodothyronine, reverse	low	15	0
glycolipids	low	3	0
salicylates	low	1	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	2	0
phytoestrogens	low	2	0
rome	low	1	0
ephrin-a5	low	1	0
vitamin b 12	low	2	0
flavin mononucleotide	medium	1	1
exudates	medium	6	1
deoxyguanosine	low	2	0
guanine	low	1	0
inosine diphosphate	medium	1	1
sapropterin	low	1	0
folic acid	low	1	0
guanylyl imidodiphosphate	low	1	0
8-hydroxy-2'-deoxyguanosine	low	2	0
cholestyramine resin	low	1	0
carbidopa	low	1	0
trypsinogen	low	1	0
leptin	low	4	0

Protein Targets (1,386)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	14	0	0	14
Chain A, RNA-directed RNA polymerase NS5	0	2	0	2
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	33	0	0	33
USP1 protein, partial	31	0	0	31
TDP1 protein	56	0	0	56
vitamin D3 receptor isoform VDRA	18	0	0	18
importin subunit beta-1 isoform 1	9	0	0	9
flap endonuclease 1	17	0	0	17
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
DNA polymerase eta isoform 1	7	0	0	7
DNA polymerase iota isoform a (long)	15	0	0	15
urokinase-type plasminogen activator precursor	13	0	0	13
plasminogen precursor	13	0	0	13
urokinase plasminogen activator surface receptor precursor	13	0	0	13
geminin	51	0	0	51
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	2	1	5
Fatty acid-binding protein, intestinal	0	2	1	3
Fatty acid-binding protein, adipocyte	0	3	2	5
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	2	2	4
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
glucocorticoid receptor [Homo sapiens]	51	0	0	51
farnesoid X nuclear receptor	32	0	0	32
estrogen nuclear receptor alpha	75	0	0	75
Voltage-dependent calcium channel gamma-2 subunit	24	0	0	24
Cellular tumor antigen p53	43	0	0	43
Glutamate receptor 2	24	2	1	27
Choline O-acetyltransferase	0	1	0	3
acetylcholinesterase	19	0	0	19
pregnane X receptor	15	0	0	15
SMAD family member 2	17	0	0	17
SMAD family member 3	17	0	0	17
GLI family zinc finger 3	45	0	0	45
Microtubule-associated protein tau	18	0	0	18
AR protein	64	0	0	64
progesterone receptor	37	0	0	37
retinoic acid nuclear receptor alpha variant 1	50	0	0	50
retinoid X nuclear receptor alpha	39	0	0	39
estrogen-related nuclear receptor alpha	57	0	0	57
pregnane X nuclear receptor	45	0	0	45
G	22	0	0	22
vitamin D (1,25- dihydroxyvitamin D3) receptor	35	0	0	35
arylsulfatase A	18	0	0	18
euchromatic histone-lysine N-methyltransferase 2	49	0	0	49
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	34	0	0	34
activating transcription factor 6	25	0	0	25
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
chromobox protein homolog 1	31	0	0	31
nuclear factor erythroid 2-related factor 2 isoform 1	49	0	0	49
survival motor neuron protein isoform d	17	0	0	17
histone acetyltransferase KAT2A isoform 1	17	0	0	17
lamin isoform A-delta10	36	0	0	36
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Glucocorticoid receptor	0	18	2	25
Sex hormone-binding globulin	0	0	8	8
Glycine receptor subunit alpha-1	0	18	0	18
Corticosteroid-binding globulin	0	6	0	6
Adenosine receptor A3	0	13	1	14
Replicase polyprotein 1ab	0	2	2	4
Androgen receptor	0	20	0	20
Alpha-1B adrenergic receptor	0	16	2	18
Glycine receptor subunit beta	0	18	0	18
Glycine receptor subunit alpha-2	0	18	0	18
Glycine receptor subunit alpha-3	0	18	0	18
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	16	3	19
Sodium-dependent dopamine transporter	0	17	0	17
TAR DNA-binding protein 43	14	0	0	14
Inositol hexakisphosphate kinase 1	22	0	0	22
cytochrome P450 2C9, partial	22	0	0	22
ATP-dependent phosphofructokinase	19	0	0	19
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	41	0	0	41
peroxisome proliferator-activated receptor delta	29	0	0	29
v-jun sarcoma virus 17 oncogene homolog (avian)	29	0	0	29
Histone H2A.x	20	0	0	20
thyroid hormone receptor beta isoform a	23	0	0	23
heat shock protein beta-1	21	0	0	21
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Proliferating cell nuclear antigen	0	4	0	4
Chain A, HADH2 protein	16	0	0	16
Chain B, HADH2 protein	16	0	0	16
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12	0	0	12
estrogen receptor 2 (ER beta)	27	0	0	27
nuclear receptor subfamily 1, group I, member 3	38	0	0	38
peroxisome proliferator activated receptor gamma	35	0	0	35
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	20	0	0	20
cytochrome P450 2C9 precursor	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
thyroid hormone receptor beta isoform 2	40	0	0	40
DNA polymerase beta	6	0	0	6
Androgen receptor	0	6	0	6
Thyroid hormone receptor alpha	0	4	4	8
Thyroid hormone receptor beta	0	4	4	8
Thyroid hormone receptor beta	0	5	0	5
Retinoic acid receptor RXR-alpha	0	0	5	5
Peroxisome proliferator-activated receptor gamma	0	0	6	6
Histamine H2 receptor	12	1	0	13
Sodium/bile acid cotransporter	0	2	0	2
Solute carrier organic anion transporter family member 1C1	0	3	0	3
caspase 7, apoptosis-related cysteine protease	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	30	0	0	30
cytochrome P450 2D6	21	0	0	21
caspase-3	9	0	0	9
thyroid stimulating hormone receptor	22	0	0	22
thyrotropin-releasing hormone receptor	7	0	0	7
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
histone deacetylase 9 isoform 3	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	17	0	0	17
Peroxisome proliferator-activated receptor alpha	3	0	1	4
ATPase family AAA domain-containing protein 5	18	0	0	18
Ataxin-2	23	0	0	23
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	18	0	0	18
tumor susceptibility gene 101 protein	1	0	0	1
Bile salt export pump	0	43	0	43
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Carbonic anhydrase 1	0	19	0	27
Carbonic anhydrase 2	0	20	2	30
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	4	1	10
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Mineralocorticoid receptor	0	3	4	7
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
phosphopantetheinyl transferase	22	0	0	22
ATAD5 protein, partial	15	0	0	15
Fumarate hydratase	11	0	0	11
NFKB1 protein, partial	6	0	0	6
PPM1D protein	6	0	0	6
Thrombopoietin	4	0	0	4
thyroid stimulating hormone receptor	20	0	0	20
EWS/FLI fusion protein	17	0	0	17
polyprotein	11	0	0	11
cytochrome P450 2D6 isoform 1	6	0	0	6
cellular tumor antigen p53 isoform a	14	0	0	14
D(1A) dopamine receptor	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	13	0	0	13
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
peripheral myelin protein 22	23	0	0	23
cytochrome P450 3A4 isoform 1	16	0	0	16
muscarinic acetylcholine receptor M1	13	0	0	13
lethal factor (plasmid)	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	16	6	3	25
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	27
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	10	0	10
Lysine-specific demethylase PHF2	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Integrin beta-3	12	0	1	13
Tyrosine-protein kinase Fyn	0	5	0	5
ATP-dependent translocase ABCB1	0	5	0	5
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	7	3	11
Muscarinic acetylcholine receptor M4	0	6	2	9
ATP-dependent translocase ABCB1	0	12	2	16
Integrin alpha-IIb	12	0	1	13
Beta-1 adrenergic receptor	0	13	2	15
Muscarinic acetylcholine receptor M5	0	6	2	9
Alpha-2A adrenergic receptor	0	15	4	21
Cytochrome P450 2C8	0	2	0	2
Muscarinic acetylcholine receptor M1	0	9	3	13
Beta-3 adrenergic receptor	0	8	1	9
D(2) dopamine receptor	0	12	3	15
Gamma-aminobutyric acid receptor subunit beta-1	16	6	3	25
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	16	2	20
Gamma-aminobutyric acid receptor subunit delta	16	6	3	25
Gamma-aminobutyric acid receptor subunit gamma-2	16	6	4	26
Gamma-aminobutyric acid receptor subunit alpha-5	16	6	3	25
Gamma-aminobutyric acid receptor subunit alpha-3	16	6	3	25
Muscarinic acetylcholine receptor M3	0	11	3	15
ATP-dependent translocase ABCB1	0	5	0	5
Substance-K receptor	0	8	0	8
D(1A) dopamine receptor	0	12	1	13
D(4) dopamine receptor	0	6	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	16	6	3	25
Gamma-aminobutyric acid receptor subunit alpha-2	16	6	3	25
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	17	0	17
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	16	2	18
5-hydroxytryptamine receptor 2C	0	11	2	13
Gamma-aminobutyric acid receptor subunit alpha-4	16	6	3	25
Gamma-aminobutyric acid receptor subunit gamma-3	16	6	3	25
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	16	6	3	25
B2 bradykinin receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	18	0	18
Melanocortin receptor 4	0	4	0	4
C-8 sterol isomerase	0	3	0	3
Melanocortin receptor 5	0	4	0	4
Mu-type opioid receptor	0	13	2	16
D(3) dopamine receptor	0	14	1	15
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	4	0	6
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	9	2	12
Kappa-type opioid receptor	0	11	2	14
5-hydroxytryptamine receptor 2B	0	12	1	13
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	4	0	4
D(1A) dopamine receptor	6	1	0	7
5-hydroxytryptamine receptor 6	0	13	1	14
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	15	0	2	17
Gamma-aminobutyric acid receptor subunit alpha-1	16	6	4	26
Gamma-aminobutyric acid receptor subunit beta-3	16	6	3	25
Gamma-aminobutyric acid receptor subunit beta-2	16	6	4	26
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	4	0	4
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Sodium channel protein type 9 subunit alpha	0	5	0	5
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	16	6	3	25
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	25	0	26
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	10	0	10
Gamma-aminobutyric acid receptor subunit epsilon	16	6	3	25
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	2	0	2
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	2	0	2
glucocerebrosidase	8	0	0	8
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Bloom syndrome protein isoform 1	14	0	0	14
neuropeptide S receptor isoform A	8	0	0	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
GLS protein	19	0	0	19
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	6	0	0	6
Cytochrome P450 3A4	0	9	1	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	1	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Translocator protein	0	0	2	2
Vasopressin V2 receptor	0	4	3	8
Oxytocin receptor	0	3	4	7
Vasopressin V1a receptor	0	1	2	3
Vasopressin V1a receptor	0	7	4	11
Vasopressin V1b receptor	0	3	3	6
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	2	0	3
Oxytocin receptor	0	2	0	2
Vasopressin V2 receptor	0	3	2	5
glp-1 receptor, partial	21	0	0	21
IDH1	18	0	0	18
aryl hydrocarbon receptor	22	0	0	22
Nuclear receptor ROR-gamma	16	0	0	16
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
interleukin 8	11	0	0	11
Smad3	4	0	0	4
67.9K protein	14	0	0	14
Parkin	3	0	0	3
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	3	0	0	3
ras-related protein Rab-9A	4	0	0	4
DNA (cytosine-5)-methyltransferase 1	0	3	0	3
Adenosine receptor A2a	0	8	4	13
Adenosine receptor A1	0	9	1	12
Multidrug and toxin extrusion protein 1	0	7	0	7
Histone-lysine N-methyltransferase EHMT2	0	4	0	4
galanin receptor type 3	0	1	0	1
ORF73	0	0	1	1
Beta-1 adrenergic receptor	0	1	3	5
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Cytochrome P450 2D6	0	4	0	4
Beta-1 adrenergic receptor	0	2	2	5
5-hydroxytryptamine receptor 1A	0	14	2	17
Beta-2 adrenergic receptor	0	0	2	2
Beta-2 adrenergic receptor	0	2	2	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, Cruzipain	5	0	0	5
caspase-1 isoform alpha precursor	4	0	0	4
Caspase-7	4	0	0	4
Inositol monophosphatase 1	8	0	0	8
Solute carrier organic anion transporter family member 1B3	0	4	0	7
Solute carrier organic anion transporter family member 1B1	0	2	0	5
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Chain A, Estrogen-related receptor gamma	0	0	1	1
Luciferase	13	0	0	13
GALC protein	9	0	0	9
GTPase KRas	0	0	1	1
Estrogen receptor	0	10	3	14
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Estrogen-related receptor gamma	0	2	1	3
GTP-binding protein Rheb	0	0	1	1
Estrogen receptor beta	0	7	3	10
Carbonic anhydrase 4	0	11	0	15
Carbonic anhydrase	0	9	0	13
Carbonic anhydrase 15	0	9	0	13
Genome polyprotein	0	1	1	2
dopamine D1 receptor	6	0	0	6
regulator of G-protein signaling 4	15	0	0	15
5-hydroxytryptamine receptor 1A	0	6	1	7
Alpha-2C adrenergic receptor	0	11	3	16
D	0	5	0	6
D(3) dopamine receptor	0	7	1	10
Alpha-2B adrenergic receptor	0	6	2	8
Alpha-2C adrenergic receptor	0	6	2	8
Alpha-2A adrenergic receptor	0	6	2	8
Alpha-1D adrenergic receptor	0	12	3	18
D(1B) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 1B	0	11	0	11
D(4) dopamine receptor	0	3	0	3
Alpha-synuclein	5	2	0	7
D(2) dopamine receptor	0	7	3	12
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Ferritin light chain	9	0	0	9
Vitamin D3 receptor	0	0	1	1
thioredoxin glutathione reductase	7	0	0	7
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	2	0	4
Vitamin D3 receptor	0	1	2	5
Cytochrome P450 2C9	0	9	1	11
Vitamin D3 receptor	0	1	1	3
Cytochrome P450 2C19	0	3	0	4
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	5
Muscarinic acetylcholine receptor M4	0	3	0	4
Muscarinic acetylcholine receptor M5	0	4	0	5
Neuronal acetylcholine receptor subunit alpha-4	2	3	0	5
Muscarinic acetylcholine receptor M2	0	3	0	4
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	2	3	0	5
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Delta-type opioid receptor	0	2	0	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-9	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	2	3
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	0	2
Vpr	2	0	0	2
Bile salt export pump	0	7	0	7
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2B6	0	1	1	2
Cytochrome P450 2J2	0	6	0	6
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Lactoperoxidase	0	2	0	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Caspase-2	0	0	1	1
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	1
15-lipoxygenase, partial	10	0	0	10
PINK1	2	0	0	2
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	10	0	0	10
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	4	0	5
Solute carrier family 22 member 1	0	11	0	14
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	6	0	6
Glutathione reductase, mitochondrial	0	3	0	4
72 kDa type IV collagenase	0	2	0	2
Matrix metalloproteinase-9	0	3	0	3
Trypanothione reductase	0	1	0	1
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Rap guanine nucleotide exchange factor 4	1	0	0	1
Spermine oxidase	0	1	0	1
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Solute carrier family 22 member 1	0	7	0	8
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	6	0	7
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Alpha-1A adrenergic receptor	0	1	1	2
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	6	2	8
Amine oxidase [flavin-containing] B	0	3	1	4
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2a	0	2	1	9
Alpha-2B adrenergic receptor	0	1	0	2
Alpha-1A adrenergic receptor	0	4	4	13
Alpha-1B adrenergic receptor	0	3	3	9
5-hydroxytryptamine receptor 7	0	5	0	5
Mu-type opioid receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	1	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Nischarin	0	2	0	2
Nischarin	0	1	0	1
nonstructural protein 1	2	0	0	2
Solute carrier family 22 member 3	0	2	0	2
endonuclease IV	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
M-phase phosphoprotein 8	7	0	0	7
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
P53	1	0	0	1
RPL19A	0	0	1	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	4	0	4
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	2	2
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	2	2
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	4	0	7
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	3	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Rap guanine nucleotide exchange factor 3	6	0	0	6
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	1	1	2
Prostaglandin G/H synthase 1	0	4	0	4
Thromboxane-A synthase	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Aldehyde oxidase	0	1	0	1
UDP-glucose 4-epimerase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	5
Cysteinyl leukotriene receptor 1	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
RGS12	1	0	0	1
WRN	3	0	0	3
eyes absent homolog 2 isoform a	2	0	0	2
C-terminal-binding protein 1	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Carbonic anhydrase 12	0	3	0	7
Epidermal growth factor receptor	0	3	0	3
Tyrosine-protein kinase Lck	0	3	0	3
Carbonic anhydrase 3	0	2	0	6
Beta-2 adrenergic receptor	0	5	1	6
POU domain, class 2, transcription factor 1	0	0	0	1
Carbonic anhydrase 6	0	3	0	7
Carbonic anhydrase 5A, mitochondrial	0	4	0	8
Carbonic anhydrase 7	0	2	0	6
Carbonic anhydrase 9	0	6	1	11
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	3	0	7
Carbonic anhydrase 5B, mitochondrial	0	2	0	6
Hsf1 protein	0	0	2	2
Taste receptor type 2 member 38	0	0	3	7
Prothrombin	0	0	2	3
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	9
Glutamate receptor ionotropic, NMDA 2B	0	3	1	9
Glutamate receptor ionotropic, NMDA 2C	0	3	1	9
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	3	1	9
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	9
Glutamate receptor ionotropic, NMDA 3A	0	3	1	9
muscleblind-like protein 1 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-1	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	1	5
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Chain A, Dihydrofolate reductase	0	0	1	1
lysosomal alpha-glucosidase preproprotein	6	0	0	6
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	1	1	2
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	6
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	1	0	2
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b	0	0	1	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
apical membrane antigen 1, AMA1	6	0	0	6
hypothetical protein, conserved	3	0	0	3
luciferase	1	0	0	1
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Vif	0	1	0	1
Tat	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	2	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	4
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A1	0	2	0	7
Carbonic anhydrase	0	0	0	4
Large neutral amino acids transporter small subunit 1	0	8	0	9
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 13	0	1	0	4
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Snq2p	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	6	0	7
5-hydroxytryptamine receptor 2A	0	6	0	6
Sphingomyelin phosphodiesterase	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	2
Sodium-dependent dopamine transporter	0	3	1	4
5-hydroxytryptamine receptor 1D	0	3	0	3
5-hydroxytryptamine receptor 1F	0	3	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	2	0	2
5-hydroxytryptamine receptor 5B	0	2	0	2
Histamine H1 receptor	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	2	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Sodium/myo-inositol cotransporter 2	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Polyphenol oxidase 2	0	6	0	10
Tyrosinase	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	6	1	10
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Iodotyrosine deiodinase	0	0	1	1
fMet-Leu-Phe receptor	0	1	0	1
Tyrosine 3-monooxygenase	0	1	0	1
Tyrosine 3-monooxygenase	0	1	0	1
Iodotyrosine deiodinase 1	0	0	1	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	2	0	2
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Sodium/iodide cotransporter	0	3	0	3
Oxytocin receptor	0	0	1	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Toll-like receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Prostaglandin G/H synthase 2	0	2	0	2
Olfactory receptor 51E2	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Pyrroline-5-carboxylate reductase 1, mitochondrial	0	1	0	1
Renin	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	0	1	1
Gastrin/cholecystokinin type B receptor	0	1	1	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain A, PROTEIN (CATECHOL OXIDASE)	0	1	0	1
Tyrosinase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
interferon gamma precursor	0	0	0	3
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Angiotensin-converting enzyme	0	4	0	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Albumin	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Dipeptidyl peptidase 4	0	0	1	1
Dipeptidyl peptidase 4	0	0	1	1
5-hydroxytryptamine receptor 2A	0	1	1	2
D	0	1	0	1
Quinolone resistance protein NorA	0	1	0	2
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	3	1	4
Synaptic vesicular amine transporter	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
tumor necrosis factor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Adenine-n6-dna-methyltransferase Taqi	0	0	1	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Ermc' Methyltransferase	0	1	0	1
Chain A, Ermc' Rrna Methyltransferase	0	1	0	1
Chain A, Uroporphyrin-III C-methyltransferase	0	1	0	1
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
tRNA (cytosine(38)-C(5))-methyltransferase	0	1	1	2
Protein arginine N-methyltransferase 5	0	1	1	2
Histone-lysine N-methyltransferase SUV39H1	0	2	0	2
Adenosylhomocysteinase	0	0	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Indolethylamine N-methyltransferase	0	1	0	1
Histone-lysine N-methyltransferase NSD2	0	1	0	1
Adenosylhomocysteinase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	1	3
rRNA adenine N-6-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-lysine N-methyltransferase SETDB1	0	1	0	1
Retinoblastoma-binding protein 5	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N6-adenosine-methyltransferase catalytic subunit	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase KMT5C	0	1	0	1
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	2	1	3
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Protein arginine N-methyltransferase 1	0	3	0	3
Methylosome protein 50	0	1	1	2
Protein dpy-30 homolog	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N-lysine methyltransferase SMYD2	0	1	0	1
Protein arginine N-methyltransferase 7	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
Set1/Ash2 histone methyltransferase complex subunit ASH2	0	1	0	1
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Non-structural protein 1	0	1	0	1
Met repressor	0	0	2	2
Histone H3K27 methylase	0	0	0	1
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Acetylcholinesterase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Renin	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
isocitrate dehydrogenase 1, partial	1	0	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Urease	0	2	0	3
Urease subunit alpha	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Urease subunit beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,892)

Protein Targets (1,386)

Cretinism

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (1,892)

Drugs Studied (272)

Protein Targets (1,386)