2-isopropoxyphenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-Isopropoxyphenol, also known as 2-hydroxyisopropylbenzene, is an organic compound with the chemical formula C9H12O2. It is a colorless liquid that is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a solvent and a stabilizer. The compound can be synthesized by reacting phenol with isopropyl alcohol in the presence of an acid catalyst. 2-isopropoxyphenol has been found to exhibit various biological activities, including antioxidant and anti-inflammatory properties. Studies have investigated its potential for treatment of certain conditions, including oxidative stress and inflammation. The compound's importance lies in its versatile applications in various fields, including pharmaceuticals, agrochemicals, and industrial processes. Research into its synthesis, properties, and potential applications continues to expand our understanding of its chemical and biological behavior.'

Cross-References

ID Source	ID
PubMed CID	20949
CHEMBL ID	3182286
CHEBI ID	38547
SCHEMBL ID	104203
MeSH ID	M0077610

Synonyms (51)

Synonym
CHEBI:38547 ,
2-(1-methylethoxy)phenol
o-isopropoxyphenol
4812-20-8
2-(propan-2-yloxy)phenol
phenol, 2-(1-methylethoxy)-
inchi=1/c9h12o2/c1-7(2)11-9-6-4-3-5-8(9)10/h3-7,10h,1-2h
2-isopropoxyphenol
2-isopropoxyphenol, 97%
2-propan-2-yloxyphenol
NCGC00248324-01
AKOS009158434
isopropyl catechol
28801-34-5
1,2-benzendiol, (1-methylethyl)-
unii-x51p4ue6x7
x51p4ue6x7 ,
einecs 225-379-1
epa pesticide chemical code 205400
caswell no. 508a
cas-4812-20-8
NCGC00255087-01
dtxsid5041431 ,
dtxcid3021431
tox21_301189
A827474
FT-0612704
SCHEMBL104203
2-isopropoxy-phenol
2-iso-propoxyphenol
[1,1'-biphenyl]-3-acetamide, n-[(3-fluorophenyl)methyl]-
phenol, 2-isopropoxy
W-109996
CHEMBL3182286
isopropoxyphenol, 2-
2-isopropyloxyphenol
2-ipp
phenol, o-isopropoxy-
ortho-isopropoxyphenol
1-hydroxy-2-isopropoxybenzene
catechol monoisopropyl ether
mfcd00002184
2-(2-propoxy)phenol
2-(1-methylethoxy)-phenol
o-isopropoxy phenol
Q26841286
AS-15515
D71146
SY062038
CS-W010952
EN300-195802

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
phenols	Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	8.6349	0.0015	30.6073	15,848.9004	AID1224849
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	24.3365	0.0002	29.3054	16,493.5996	AID743079
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	4 (50.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.33 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	5.00 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.33)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (12.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
propoxur Propoxur: A carbamate insecticide.. propoxur : A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.	9.46	5	1	aromatic ether; carbamate ester	acaricide; agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor
bisphenol a 4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.	2.08	1	0	bisphenol	endocrine disruptor; environmental contaminant; xenobiotic; xenoestrogen
2-naphthol 2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.	2.08	1	0	naphthol	antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger
3,5,6-trichloro-2-pyridinol 3,5,6-trichloro-2-pyridinol: RN given refers to parent cpd. 3,5,6-trichloropyridine-2-one : A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.. 3,5,6-trichloro-2-pyridinol : A hydroxypyridine that is pyridin-2-ol substituted by chloro groups at positions 3,5 and 6. It is a metabolite of the agrochemical chlorpyrifos.	2.08	1	0	chloropyridine; hydroxypyridine; pyridone	human urinary metabolite; human xenobiotic metabolite; marine xenobiotic metabolite
genistein [no description available]	2.08	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
daidzein [no description available]	2.08	1	0	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.41	2	0

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