1,6-hexanediol dimethacrylate profile

1,6-hexanediol dimethacrylate (HDDA) is a bifunctional monomer widely used in the synthesis of polymers, particularly in the fabrication of dental materials, coatings, and adhesives. HDDA is typically synthesized through the reaction of 1,6-hexanediol with methacrylic acid in the presence of a catalyst. Its unique properties, including its high reactivity and ability to form cross-linked networks, make it a valuable component in dental composites. The cross-linking ability of HDDA contributes to the strength and durability of these materials, making them suitable for fillings, crowns, and other dental applications. Studies on HDDA focus on understanding its polymerization behavior, optimizing its use in dental formulations, and assessing its biocompatibility and potential toxicity. The compound's effects on dental health, including its potential to cause irritation or allergic reactions, are subjects of ongoing research.'

ID Source	ID
PubMed CID	81080
CHEMBL ID	3183323
SCHEMBL ID	24216
MeSH ID	M0240224

Synonym
rao49190jv ,
2-propenoic acid, 2-methyl-, 1,1'-(1,6-hexanediyl) ester
unii-rao49190jv
1,6-hexanediol dimethacrylate, contains 100 ppm hydroquinone as inhibitor, >=90%
1,6-hexanediol dimethacrylate
ccris 7049
1,6-hexanediyl bismethacrylate
einecs 229-551-7
2-propenoic acid, 2-methyl-, 1,6-hexanediyl ester
6606-59-3
6-(2-methylprop-2-enoyloxy)hexyl 2-methylprop-2-enoate
H1369
1,6-bis(methacryloyloxy)hexane
NCGC00255742-01
cas-6606-59-3
dtxcid7024455
tox21_302093
dtxsid9044455 ,
AKOS015902853
BP-30168
SCHEMBL24216
hexane-1,6-diyl bis(2-methylacrylate)
hexamethylene dimethacrylate
W-104775
1,6-hexyleneglycol dimethacrylate
hddma
hexamethylene methacrylate
methacrylic acid, hexamethylene ester
1,6-hexamethylenediol dimethacrylate
1,6-hexamethylene dimethacrylate
hexamethylene glycol dimethacrylate
1,6-hexanediyl dimethacrylate
1,6-hexanediol, dimethacrylate
1,6-hexamethylene glycol dimethacrylate
hexamethylene glycol methacrylate
CHEMBL3183323
mfcd00015425
6-[(2-methylprop-2-enoyl)oxy]hexyl 2-methylprop-2-enoate
AS-59874
1,6-hexanediol dimethacrylate, 95%, contains 100ppm mehq as stabilizer
1,6-hexanediol dimethacrylate (stabilized with mehq)
FT-0734188
1,6-hexanedioldimethacrylate
1,6-hexanediol dimethacrylate,min 98%
1,6-hexanediol dimethacrylate(8 cp(23 degrees c))
Q27288026
2-propenoic acid, 2-methyl-, 1,6-hexanediyl ester; 1,6-hexanediol dimethacrylate
A867535
hexane-1,6-diylbis(2-methylacrylate)
F71251

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
AR protein	Homo sapiens (human)	Potency	1.5260	0.0002	21.2231	8,912.5098	AID743035; AID743063
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	0.9689	0.0017	23.8393	78.1014	AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (29.17)	18.2507
2000's	8 (33.33)	29.6817
2010's	9 (37.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (3.85%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
1-butanol 1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.. butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.	2.06	1	0	alkyl alcohol; primary alcohol; short-chain primary fatty alcohol	human metabolite; mouse metabolite; protic solvent
phosphoric acid phosphoric acid: concise etchant is 37% H3PO4. phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.	3.45	1	1	phosphoric acids	algal metabolite; fertilizer; human metabolite; NMR chemical shift reference compound; solvent
sulfites Sulfites: Inorganic salts of sulfurous acid.. sulfites : Any sulfurous acid derivative that is a salt or an ester of sulfurous acid.. organosulfonate oxoanion : An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid.. sulfite : A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3).	2	1	0	divalent inorganic anion; sulfur oxide; sulfur oxoanion
methylene blue Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.. methylene blue : An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.	2.11	1	0	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	2.02	1	0	alkadiene; hemiterpene; volatile organic compound	plant metabolite
bisphenol a 4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.	2.39	2	0	bisphenol	endocrine disruptor; environmental contaminant; xenobiotic; xenoestrogen
methylmethacrylate Methylmethacrylate: The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.. methyl methacrylate : An enoate ester having methacrylic acid as the carboxylic acid component and methanol as the alcohol component.	3.11	5	0	enoate ester; methyl ester	allergen; polymerisation monomer
butyl methacrylate [no description available]	2.03	1	0	enoate ester
ethylene dimethacrylate ethylene glycol dimethacrylate : The enoate ester that is the 1,2-bis(methacryloyl) derivative of ethylene glycol.	2.39	2	0	enoate ester	allergen; cross-linking reagent; polymerisation monomer
glycidyl methacrylate glycidyl methacrylate: RN given refers to monomer. glycidyl methacrylate : An enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol.	1.98	1	0	enoate ester; epoxide
triethylene glycol dimethacrylate [no description available]	4.89	8	1
diethylene glycol glycol ether : A hydroxyether which contains both an ether and alcohol functional groups. It is one of the most versatile classes of organic solvents which are commonly used in paints, cleaners, adhesives, pharmaceuticals and cosmetics.	1.99	1	0	hydroxyether
hexyl methacrylate hexyl methacrylate: used to make monolithic columns	2.11	1	0
lauryl methacrylate dodecyl methacrylate: monomer unit of various acrylate polymers used to form gels,plastics and some biocompatible materials; structure in first source	2.15	1	0
hydroxyethyl methacrylate hydroxyethyl methacrylate: many of cited refs are for gel which refers to polymeric form of above cpd: POLYHYDROXYETHYL METHACRYLATE. 2-hydroxyethyl methacrylate : An enoate ester that is the monomethacryloyl derivative of ethylene glycol.	4.52	5	1	enoate ester	allergen; polymerisation monomer
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	3.45	1	1
bisphenol a-glycidyl methacrylate Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	3.41	7	0	diarylmethane
tetrabutylammonium tetrabutylammonium: lipophilic probe; RN given refers to parent cpd	2.05	1	0	quaternary ammonium ion
3-(trimethoxysilyl)propyl methacrylate 3-(trimethoxysilyl)propyl methacrylate: structure in first source	1.98	1	0
2-(dimethylamino)ethyl methacrylate 2-(dimethylamino)ethyl methacrylate: reducing agent; structure given in first source	2.07	1	0
trimethylolpropane trimethacrylate trimethylolpropane trimethacrylate: acrylate derivative found in ultraviolet curing inks; structure in 1st source	2.7	3	0	carbonyl compound
neon Neon: A noble gas with the atomic symbol Ne, atomic number 10, and atomic weight 20.18. It is found in the earth's crust and atmosphere as an inert, odorless gas and is used in vacuum tubes and incandescent lamps.	2.03	1	0	monoatomic neon; noble gas atom; p-block element atom
helium Helium: A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics.	2.03	1	0	monoatomic helium; noble gas atom; s-block element atom	food packaging gas
zirconium Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.	2.91	4	0	titanium group element atom
sodium sulfite [no description available]	2	1	0	inorganic sodium salt; sulfite salt	food preservative; reducing agent
camphoroquinone camphoroquinone: a natural monoterpene, non-aromatic quinone; structure given in first source. bornane-2,3-dione : A bornane monoterpenoid that is bicyclo[2.2.1]heptane substituted by methyl groups at positions 1, 7 and 7 and oxo groups at positions 2 and 3.	1.98	1	0	bornane monoterpenoid; carbobicyclic compound
1,6-hexanediol diacrylate [no description available]	2.5	2	0
fluorides [no description available]	2.05	1	0	halide anion; monoatomic fluorine
butanediol diacrylate butanediol diacrylate: RN given is for 1,4-butanediol diacrylate; structure	2.39	2	0
n,n-bis(2-hydroxyethyl)-4-toluidine N,N-bis(2-hydroxyethyl)-4-toluidine: lysosome stabilizing agent	1.98	1	0
monomethyl succinate monomethyl succinate: RN given refers to parent cpd. monomethyl succinate : A dicarboxylic acid monoester that is succinic acid in which one of the carboxy groups has been converted to its methyl ester.	2.06	1	0	dicarboxylic acid monoester; hemisuccinate
3-acryloxypropyltrimethoxysilane [no description available]	1.98	1	0
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.98	1	0

Condition	Relationship Strength	Studies	Trials
Dental Leakage The seepage of fluids, debris, and micro-organisms between the walls of a prepared dental cavity and the restoration.	4.16	3	1
Tooth Fractures Break or rupture of a tooth or tooth root.	3.45	1	1
Smear Layer Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.	3.45	1	1

1,6-hexanediol dimethacrylate

Cross-References

Synonyms (50)

Protein Targets (2)

Potency Measurements

Research

Studies (24)

Market Indicators

Research Demand Index: 36.47

Study Types