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bisphenol a glucuronide

Description

bisphenol A glucuronide: metabolite of bisphenol A; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID71309820
MeSH IDM0500412

Synonyms (9)

Synonym
bisphenol a beta-d-glucuronide
bisphenol a glucuronide
267244-08-6
bisphenol a mono-beta-d-glucuronide, 95% (cp)
DTXSID10873181
(2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2h-pyran-2-carboxylic acid
BS-53271
STARBLD0018869
F77023

Research

Studies (50)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (8.00)29.6817
2010's43 (86.00)24.3611
2020's3 (6.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.00%)5.53%
Reviews2 (4.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (94.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
antipyrinepyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
2010201014.0low000100
triclosanaromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols
antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
2014201410.0low000010
bisphenol abisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
200520219.7high1006391
bis(4-hydroxyphenyl)sulfonebisphenol;
sulfone
endocrine disruptor;
metabolite
201920195.0low000020
dihydrotestosterone17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid
androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
202120213.0low000001
uridine diphosphate glucuronic acidUDP-D-glucuronic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite
2007200717.0low000100
fluorescein-5-isothiocyanatefluorescein isothiocyanate2010201014.0low000100
deuteriumdihydrogen2012201212.0low000010
n-methyl-n-(trimethylsilyl)trifluoroacetamidemonocarboxylic acid amide;
N-silyl compound;
trifluoroacetamide
chromatographic reagent2014201410.0low000010
fulvestrant17beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide
antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
201520159.0low000010
genistein7-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
2011201113.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Allergic Reaction0201620168.0low000010
Asthma0202020204.0low000010
Asthma, Bronchial0202020204.0low000010
Birth Weight0201520159.0low000010
Breast Cancer02014201410.0low000010
Breast Neoplasms02014201410.0low000010
Delayed Effects, Prenatal Exposure0201720177.0low000010
Fetal Growth Restriction0201520159.0low000010
Fetal Growth Retardation0201520159.0low000010
Hypersensitivity0201620168.0low000010
Idiopathic Parkinson Disease0201720177.0low000010
Parkinson Disease0201720177.0low000010
Pregnancy0201020218.7high0002141

Safety/Toxicity (1)

ArticleYear
New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure.
Environmental pollution (Barking, Essex : 1987), , Volume: 242, Issue:Pt A
2018

Pharmacokinetics (4)

ArticleYear
Pharmacokinetics of bisphenol A in humans following a single oral administration.
Environment international, , Volume: 83
2015
Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration.
Toxicology, , Jul-03, Volume: 333
2015
Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling.
Regulatory toxicology and pharmacology : RTP, , Volume: 72, Issue:1
2015
Prediction of metabolic clearance of bisphenol A (4,4 '-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 35, Issue:10
2007

Bioavailability (2)

ArticleYear
24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup.
Toxicology and applied pharmacology, , Oct-15, Volume: 288, Issue:2
2015
High bioavailability of bisphenol A from sublingual exposure.
Environmental health perspectives, , Volume: 121, Issue:8
2013

Dosage (5)

ArticleYear
Determination of free and total bisphenol A in the urine and feces of orally and subcutaneously dosed sheep by high-performance liquid chromatography with fluorescence detection.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, , Volume: 55, Issue:7
2020
Prediction of human prenatal exposure to bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic model.
Scientific reports, , 11-10, Volume: 7, Issue:1
2017
Pharmacokinetics of bisphenol A in humans following a single oral administration.
Environment international, , Volume: 83
2015
Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration.
Toxicology, , Jul-03, Volume: 333
2015
High bioavailability of bisphenol A from sublingual exposure.
Environmental health perspectives, , Volume: 121, Issue:8
2013