Page last updated: 2024-09-22

2,5,2',5'-tetrachlorobiphenyl

Description

2,2',5,5'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at the 2 and 5 position of each benzene ring are replaced by chlorines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID37248
CHEMBL ID273933
CHEBI ID34206
SCHEMBL ID440944
MeSH IDM0054063

Synonyms (36)

Synonym
2,2',5,5'-tetrachloro-1,1'-biphenyl
2,5,2',5'-tetrachlorobiphenyl
2,3',5,6'-tetrachlorobiphenyl
CHEBI:34206 ,
tcbp
ccris 6155
brn 2053828
2,2',5,5'-tcb
pcb 52
35693-99-3
1,1'-biphenyl, 2,2',5,5'-tetrachloro-
2,2',5,5'-tetrachlorobiphenyl
inchi=1/c12h6cl4/c13-7-1-3-11(15)9(5-7)10-6-8(14)2-4-12(10)16/h1-6
2,2 ,5,5 -tetrachlorobiphenyl
pcb-52
1,4-dichloro-2-(2,5-dichlorophenyl)benzene
CHEMBL273933
2,5,2',5'-tetrachloro-biphenyl
1eh557950r ,
4-05-00-01818 (beilstein handbook reference)
unii-1eh557950r
pcb no 52
AKOS015902969
SCHEMBL440944
tetrachlorobiphenyl, 2,2',5,5'-
HCWZEPKLWVAEOV-UHFFFAOYSA-N
DTXSID3038305 ,
2,2',5,5'-tetrachlorobiphenyl (iupac no. 52), bcr(r) certified reference material
pcb no 52, analytical standard
pcb no. 52
pcb no. 52 10 microg/ml in isooctane
Q27115903
pcb no. 52 100 microg/ml in hexane
pcb no. 52 100 microg/ml in isooctane
pcb no. 52 50 microg/ml in acetonitrile
dtxcid1018305

Drug Classes (2)

ClassDescription
tetrachlorobiphenylAny polychlorobiphenyl with molecular formula C12H6Cl4.
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID23673Partition coefficient (logP)2002Bioorganic & medicinal chemistry letters, Apr-08, Volume: 12, Issue:7
Novel estimation of lipophilic behaviour of polychlorinated biphenyls.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (100)

TimeframeStudies, This Drug (%)All Drugs %
pre-199014 (14.00)18.7374
1990's20 (20.00)18.2507
2000's31 (31.00)29.6817
2010's33 (33.00)24.3611
2020's2 (2.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (0.98%)4.05%
Observational0 (0.00%)0.25%
Other101 (99.02%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (6)

ArticleYear
PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.
Chemosphere, Volume: 227
2019
PCB28 and PCB52 induce hepatotoxicity by impairing the autophagic flux and stimulating cell apoptosis in vitro.
Toxicology letters, Jun-01, Volume: 289
2018
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Environmental science & technology, Mar-15, Volume: 50, Issue: 6
2016
Genotoxic effects of PCB 52 and PCB 77 on cultured human peripheral lymphocytes.
Mutation research, Jun-30, Volume: 654, Issue: 1
2008
The pharmacokinetics of 2,2',5,5'-tetrachlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl and its relationship to toxicity.
Toxicology and applied pharmacology, Sep-01, Volume: 100, Issue: 2
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (3)

ArticleYear
PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats.
Chemosphere, Volume: 227
2019
Dose determinations for waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl and related pharmacokinetics in two species of trout (Salmo gairdneri and Salvelinus fontinalis): a mass-balance approach.
Toxicology and applied pharmacology, Volume: 68, Issue: 2
1983
The pharmacokinetics of 2,2',5,5'-tetrachlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl and its relationship to toxicity.
Toxicology and applied pharmacology, Sep-01, Volume: 100, Issue: 2
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (3)

ArticleYear
Bioavailability of 2,3',4,4',5-pentachlorobiphenyl (PCB118) and 2,2',5,5'-tetrachlorobiphenyl (PCB52) from soils using a rat model and a physiologically based extraction test.
Toxicology, Jan-05, Volume: 217, Issue: 1
2006
Effects of particulate carbonaceous matter on the bioavailability of benzo[a]pyrene and 2,2',5,5'-tetrachlorobiphenyl to the clam, Macoma balthica.
Environmental science & technology, Sep-01, Volume: 38, Issue: 17
2004
An experimental design to probe the interactions of dissolved organic matter and xenobiotics: bioavailability of pyrene and 2,2',5,5'-tetrachlorobiphenyl to Daphnia magna.
Chemosphere, Volume: 38, Issue: 2
1999
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (2)

ArticleYear
A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: II. simulation of chronic exposure scenarios.
Toxicological sciences : an official journal of the Society of Toxicology, Volume: 77, Issue: 2
2004
The pharmacokinetics of 2,2',5,5'-tetrachlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl and its relationship to toxicity.
Toxicology and applied pharmacology, Sep-01, Volume: 100, Issue: 2
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]