| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| 2-aminofluorene | [no description available] | medium | 5 | 0 | | |
| amitrole | [no description available] | medium | 1 | 0 | aromatic amine;
triazoles | carotenoid biosynthesis inhibitor;
EC 1.11.1.6 (catalase) inhibitor;
herbicide |
| azathioprine | [no description available] | medium | 1 | 0 | aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine | antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug |
| suramin | [no description available] | medium | 1 | 0 | naphthalenesulfonic acid;
phenylureas;
secondary carboxamide | angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug |
| n-hydroxy-2-aminofluorene | [no description available] | medium | 1 | 0 | | |
| hydroxyacetylaminofluorene | [no description available] | medium | 1 | 0 | 2-acetamidofluorenes | |
| 2-acetylaminofluorene | [no description available] | medium | 3 | 0 | 2-acetamidofluorenes | antimitotic;
carcinogenic agent;
epitope;
mutagen |
| p-aminoazobenzene | [no description available] | medium | 1 | 0 | | |
| 1-phenylazo-2-naphthylamine | [no description available] | medium | 1 | 0 | | |
| 2-naphthylamine | [no description available] | medium | 2 | 0 | naphthylamine | carcinogenic agent |
| 3,3'-dichlorobenzidine | [no description available] | medium | 1 | 0 | biphenyls;
monochlorobenzenes;
organochlorine compound | |
| 4-biphenylamine | [no description available] | medium | 5 | 0 | aminobiphenyl | carcinogenic agent |
| benzidine | [no description available] | medium | 2 | 0 | biphenyls;
substituted aniline | carcinogenic agent |
| o-aminoazotoluene | [no description available] | medium | 1 | 0 | | |
| methylenebis(chloroaniline) | [no description available] | medium | 2 | 0 | chloroaniline | metabolite |
| 4,4'-diaminodiphenylmethane | [no description available] | medium | 1 | 0 | aromatic amine | allergen;
carcinogenic agent |
| 2-tolidine | [no description available] | medium | 1 | 0 | biphenyls | |
| yellow ob | [no description available] | medium | 1 | 0 | | |
| 2,7-diacetylaminofluorene | [no description available] | medium | 1 | 0 | | |
| 2,7-fluorenediamine | [no description available] | medium | 1 | 0 | | |
| n-hydroxy-1-naphthylamine | [no description available] | medium | 1 | 0 | N-substituted amine | |
| 1-aminoanthracene | [no description available] | medium | 1 | 0 | anthracenamine | |
| 2-anthramine | [no description available] | medium | 1 | 0 | anthracenamine | |
| 4,4'-methylene bis(2-methylaniline) | [no description available] | medium | 1 | 0 | diarylmethane | |
| 9-aminophenanthrene | [no description available] | medium | 1 | 0 | phenanthrenamine | |
| 3-methoxy-4-aminoazobenzene | [no description available] | medium | 1 | 0 | | |
| n-hydroxy-n-(2-fluorenyl)benzamide | [no description available] | medium | 1 | 0 | | |
| 4-acetylaminobiphenyl | [no description available] | medium | 1 | 0 | biphenyls | |
| 2-acetamidophenanthrene | [no description available] | medium | 1 | 0 | | |
| n-hydroxy-4-acetylaminobiphenyl | [no description available] | medium | 1 | 0 | hydroxamic acid | |
| acetoxyacetylaminofluorene | [no description available] | medium | 1 | 0 | 2-acetamidofluorenes | carcinogenic agent;
mutagen |
| 3-acetylaminofluorene | [no description available] | medium | 1 | 0 | | |
| fanft | [no description available] | medium | 1 | 0 | | |
| N-fluorenylacetamide | [no description available] | medium | 1 | 0 | fluorenes | |
| acridine orange | [no description available] | medium | 1 | 0 | aminoacridines;
aromatic amine;
tertiary amino compound | fluorochrome;
histological dye |
| n-hydroxy-2-naphthylamine | [no description available] | medium | 1 | 0 | | |
| n-acetoxy-4-acetylaminobiphenyl | [no description available] | medium | 1 | 0 | | |
| 7-iodo-n-2-acetylaminofluorene | [no description available] | medium | 1 | 0 | | |
| n-hydroxy-4-aminoazobenzene | [no description available] | medium | 1 | 0 | | |
| 4-dimethylaminostilbene | [no description available] | medium | 1 | 0 | | |
| 4-acetylaminostilbene | [no description available] | medium | 1 | 0 | | |
| 4-aminostilbene | [no description available] | medium | 1 | 0 | | |
| nefurthiazole | [no description available] | medium | 1 | 0 | C-nitro compound;
furans | |
| 4,4'-diaminostilbene | [no description available] | medium | 1 | 0 | | |
| 1,2-dimethylhydrazine | [no description available] | medium | 3 | 0 | hydrazines | alkylating agent;
carcinogenic agent |
| 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | [no description available] | medium | 8 | 0 | imidazopyridine;
primary amino compound | carcinogenic agent;
mutagen |
| ethinyl estradiol | [no description available] | medium | 8 | 0 | 17-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound | xenoestrogen |
| bisphenol a | [no description available] | medium | 1 | 0 | bisphenol | endocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen |
| 4-tert-octylphenol | [no description available] | medium | 1 | 0 | alkylbenzene | |
| butylbenzyl phthalate | [no description available] | medium | 1 | 0 | benzyl ester | |
| cyclin d1 | [no description available] | medium | 1 | 0 | | |
| bicalutamide | [no description available] | medium | 2 | 0 | (trifluoromethyl)benzenes;
monocarboxylic acid amide;
monofluorobenzenes;
nitrile;
sulfone;
tertiary alcohol | |
| 4-nitroquinoline-1-oxide | [no description available] | medium | 3 | 0 | C-nitro compound;
quinoline N-oxide | carcinogenic agent |
| celecoxib | [no description available] | medium | 2 | 0 | organofluorine compound;
pyrazoles;
sulfonamide;
toluenes | cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug |
| sulindac | [no description available] | medium | 1 | 0 | monocarboxylic acid;
organofluorine compound;
sulfoxide | analgesic;
antineoplastic agent;
antipyretic;
apoptosis inducer;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug;
tocolytic agent |
| diphenylamine | [no description available] | medium | 15 | 0 | aromatic amine;
bridged diphenyl fungicide;
secondary amino compound | antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger |
| lignin | [no description available] | medium | 1 | 0 | | |
| benzo(a)pyrene | [no description available] | medium | 1 | 0 | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite |
| 1-naphthylisothiocyanate | [no description available] | medium | 1 | 0 | isothiocyanate | insecticide |
| methapyrilene | [no description available] | medium | 1 | 0 | ethylenediamine derivative | anti-allergic agent;
carcinogenic agent;
H1-receptor antagonist;
sedative |
| 9,10-dimethyl-1,2-benzanthracene | [no description available] | medium | 4 | 0 | ortho-fused polycyclic arene;
tetraphenes | carcinogenic agent |
| dimethyl sulfoxide | [no description available] | medium | 2 | 0 | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger |
| disulfiram | [no description available] | medium | 1 | 0 | organic disulfide;
organosulfur acaricide | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor |
| cadmium | [no description available] | medium | 1 | 0 | cadmium molecular entity;
zinc group element atom | |
| methylnitronitrosoguanidine | [no description available] | medium | 3 | 0 | nitroso compound | alkylating agent |
| 3-amino-1-methyl-5h-pyrido(4,3-b)indole | [no description available] | medium | 1 | 0 | pyridoindole | |
| acetone | [no description available] | medium | 1 | 0 | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent |
| phosphorus radioisotopes | [no description available] | medium | 1 | 0 | | |
| butylhydroxybutylnitrosamine | [no description available] | medium | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
| n-ethyl-n-(4-hydroxybutyl)nitrosamine | [no description available] | medium | 1 | 0 | | |
| azoxymethane | [no description available] | medium | 1 | 0 | | |
| dimethylhydrazines | [no description available] | medium | 1 | 0 | | |
| chlorine | [no description available] | medium | 1 | 0 | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite |
| palmitic acid | [no description available] | medium | 1 | 0 | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite |
| dihydrotestosterone | [no description available] | medium | 1 | 0 | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite |
| hydroxyurea | [no description available] | medium | 1 | 0 | one-carbon compound;
ureas | antimetabolite;
antimitotic;
antineoplastic agent;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
genotoxin;
immunomodulator;
radical scavenger;
teratogenic agent |
| phenobarbital | [no description available] | medium | 1 | 0 | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative |
| nafenopin | [no description available] | medium | 1 | 0 | aromatic ether;
monocarboxylic acid | |
| diethylnitrosamine | [no description available] | medium | 2 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
| delphinidin | [no description available] | medium | 2 | 0 | anthocyanidin chloride | |
| diisopropanolnitrosamine | [no description available] | medium | 2 | 0 | diol;
nitrosamine;
secondary alcohol | carcinogenic agent |
| n-ethyl-n-hydroxyethylnitrosamine | [no description available] | medium | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
| dihydroguaiaretic acid | [no description available] | medium | 1 | 0 | | |
| lignans | [no description available] | medium | 1 | 0 | | |
| phytic acid | [no description available] | medium | 2 | 0 | inositol phosphate | |
| guaiacol | [no description available] | medium | 1 | 0 | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite |
| curcumin | [no description available] | medium | 2 | 0 | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger |
| bromodeoxyuridine | [no description available] | medium | 1 | 0 | pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent |
| dinoprostone | [no description available] | medium | 1 | 0 | prostaglandins E | human metabolite;
mouse metabolite;
oxytocic |
| indomethacin | [no description available] | medium | 1 | 0 | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic |
| finasteride | [no description available] | medium | 1 | 0 | 3-oxo steroid;
aza-steroid;
delta-lactam | androgen antagonist;
antihyperplasia drug;
EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor |
| diethylstilbestrol | [no description available] | medium | 1 | 0 | olefinic compound;
polyphenol | antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen |
| selenomethionine | [no description available] | medium | 1 | 0 | selenoamino acid;
selenomethionines | plant metabolite |
| sodium selenite | [no description available] | medium | 1 | 0 | inorganic sodium salt;
selenite salt | nutraceutical |
| selenic acid | [no description available] | medium | 1 | 0 | selenium oxoacid | |
| selenium | [no description available] | medium | 3 | 0 | chalcogen;
nonmetal atom | micronutrient |
| manganese | [no description available] | medium | 1 | 0 | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient |
| genistein | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor |
| methylnitrosourea | [no description available] | medium | 5 | 0 | N-nitrosoureas | alkylating agent;
carcinogenic agent;
mutagen;
teratogenic agent |
| nitrosobis(2-oxopropyl)amine | [no description available] | medium | 2 | 0 | ketone;
nitrosamine | carcinogenic agent |
| genistin | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones 7-O-beta-D-glucoside | |
| daidzin | [no description available] | medium | 1 | 0 | 7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative | plant metabolite |
| lycopene | [no description available] | medium | 1 | 0 | acyclic carotene | antioxidant;
plant metabolite |
| alpha-linolenic acid | [no description available] | medium | 1 | 0 | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical |
| acetaminophen | [no description available] | medium | 1 | 0 | acetamides;
phenols | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic |
| 4-octylphenol | [no description available] | medium | 1 | 0 | phenols | metabolite;
surfactant;
xenoestrogen |
| n-hydroxy-3,2'-dimethyl-4-aminobiphenyl | [no description available] | medium | 3 | 0 | | |
| mebeverine | [no description available] | medium | 2 | 0 | | |
| chlormadinone acetate | [no description available] | medium | 1 | 0 | corticosteroid hormone | |
| catechol | [no description available] | medium | 1 | 0 | catechols | allelochemical;
genotoxin;
plant metabolite |
| hydroquinone | [no description available] | medium | 1 | 0 | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent |
| d-alpha tocopherol | [no description available] | medium | 1 | 0 | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite |
| resorcinol | [no description available] | medium | 1 | 0 | benzenediol;
phenolic donor;
resorcinols | erythropoietin inhibitor;
sensitiser |
| acid phosphatase | [no description available] | medium | 1 | 0 | | |
| cyproterone | [no description available] | medium | 1 | 0 | 17alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(4) steroid;
chlorinated steroid;
tertiary alpha-hydroxy ketone | androgen antagonist |
| cyproterone acetate | [no description available] | medium | 1 | 0 | 20-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester | androgen antagonist;
geroprotector;
progestin |
| bromocriptine | [no description available] | medium | 1 | 0 | indole alkaloid | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
hormone antagonist |
| methyltestosterone | [no description available] | medium | 1 | 0 | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone | anabolic agent;
androgen;
antineoplastic agent |
| paraoxon | [no description available] | medium | 1 | 0 | aryl dialkyl phosphate;
organophosphate insecticide | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite |