2-ethyl-5-carboxypentyl phthalate profile

2-ethyl-5-carboxypentyl phthalate: urinary metabolite of diethylhexyl phthalate; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

mono(5-carboxy-2-ethylpentyl) phthalate : A phthalic acid monoester resulting from the formal condensation of one of the carboxy gruops of phthalic acid with the hydroxy group of 5-(hydroxymethyl)heptanoic acid. It is a urinary metabolite of diethylhexyl phthalate. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	148386
CHEBI ID	132611
SCHEMBL ID	15647174
MeSH ID	M0146427

Synonym
mecpp
1,2-benzenedicarboxylic acid, mono(5-carboxy-2-ethylpentyl) ester
mono(5-carboxy-2-ethylpentyl) phthalate
ccris 4305
2-ethyl-5-carboxypentyl phthalate
phthalic acid, mono(5-carboxy-2-ethylpentyl) ester
CHEBI:132611
40809-41-4
2-{[(5-carboxy-2-ethylpentyl)oxy]carbonyl}benzoic acid
1,2-benzenedicarboxylic acid mono(5-carboxy-2-ethylpentyl) ester
rac mono(5-carboxy-2-ethylpentyl) phthalate
FT-0672459
mono(2-ethyl-5-carboxypentyl) phthalate
5-cx-mepp
SCHEMBL15647174
mono-(2-ethyl-5-carboxypentyl) phthalate
phthalic acid mono(5-carboxy-2-ethylpentyl)ester
2-(5-carboxy-2-ethyl-pentoxy)carbonylbenzoic acid
DTXSID20873152
Q27225619
2-(5-carboxy-2-ethylpentoxy)carbonylbenzoic acid
HY-133675
CS-0128983

Role	Description
xenobiotic	A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
phthalic acid monoester	A dicarboxylic acid monoester resulting from the formal condensation of an alcoholic or aromatic hydroxy group with just one of the two carboxy groups of phthalic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (66.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2,5-dichlorophenol 2,5-dichlorophenol: structure given in first source. 2,5-dichlorophenol : A dichlorophenol with the chloro substituents at positions 2 and 5.	2.06	1	dichlorophenol	human xenobiotic metabolite
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	1.97	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
phthalic acid phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.	3.06	1	benzenedicarboxylic acid	human xenobiotic metabolite
2,3,4,6-tetrachlorophenol 2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.	2.06	1	tetrachlorophenol	xenobiotic metabolite
bisphenol a 4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.	2.06	1	bisphenol	endocrine disruptor; environmental contaminant; xenobiotic; xenoestrogen
diethyl phthalate diethyl phthalate: structure. diethyl phthalate : The diethyl ester of benzene-1,2-dicarboxylic acid.	2.06	1	diester; ethyl ester; phthalate ester	neurotoxin; plasticiser; teratogenic agent
diethylhexyl phthalate Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	4.07	5	diester; phthalate ester	androstane receptor agonist; apoptosis inhibitor; plasticiser
2,4-dichlorophenol 2,4-dichlorophenol: RN given refers to unlabeled parent+ cpd; structure. 2,4-dichlorophenol : A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.	2.06	1	dichlorophenol
monobutyl phthalate monobutyl phthalate: RN given refers to parent cpd	2.47	2	phthalic acid monoester
mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate: RN given refers to parent cpd. mono(2-ethylhexyl) phthalate : The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	2.53	2	phthalic acid monoester
mono(2-ethyl-5-oxohexyl)phthalate mono(2-ethyl-5-oxohexyl)phthalate: structure given in first source. mono(2-ethyl-5-oxohexyl) phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of 2-ethyl-5-oxohexan-1-ol.	3.74	3	methyl ketone; phthalic acid monoester	human urinary metabolite; human xenobiotic metabolite
mono(2-ethyl-5-hydroxyhexyl) phthalate mono(2-ethyl-5-hydroxyhexyl) phthalate: a metabolite of bis(2-ethylhexyl) phthalate. mono(2-ethyl-5-hydroxyhexyl) phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the primary hydroxy group of 2-ethylhexane-1,5-diol	3.74	3	phthalic acid monoester	human urinary metabolite; human xenobiotic metabolite

Condition	Relationship Strength	Studies
Adenoma, Prostatic [description not available]	2.31	1
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	2.31	1
Reproductive Sterility [description not available]	3.06	1
Infertility A reduced or absent capacity to reproduce.	3.06	1
Fibroid [description not available]	2.15	1
Cancer of the Uterus [description not available]	2.15	1
Leiomyoma A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.	2.15	1
Uterine Neoplasms Tumors or cancer of the UTERUS.	2.15	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.06	1

2-ethyl-5-carboxypentyl phthalate

Description

Cross-References

Synonyms (23)

Roles (1)

Drug Classes (1)

Research

Studies (6)

Market Indicators

Research Demand Index: 21.55

Study Types