Page last updated: 2024-09-27

Injuries, Preconception

Damages to reproductive health prior to conception (FERTILIZATION), a legal term for torts liability concerning environmental safety issues. Preconception injuries may involve either the male or the female, such as chromosomal mutations in the OVA or the SPERMATOZOA.

Synonyms(2)

Synonym
Injuries, Preconception
Preconception Injuries

Research

Studies (9)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's3 (33.33)18.1394
2010's5 (55.56)28.8240
2020's1 (11.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
methanol0low10
sulfur dioxide0low10
acetazolamide0low10
avapro0low10
metformin0low10
mitoxantrone0low10
ondansetron0low10
bisphenol a0low10
diethylstilbestrol0low10
nitrogen dioxide0low10
genistein0low10

Protein Targets (530)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase1001
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase2002
GALC protein2002
GLI family zinc finger 34004
nuclear receptor subfamily 1, group I, member 34004
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha5005
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A2002
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 23003
Bloom syndrome protein isoform 13003
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 16006
geminin4004
peripheral myelin protein 224004
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 12002
Gamma-aminobutyric acid receptor subunit pi5308
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump0404
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10318
Carbonic anhydrase 20317
Carbonic anhydrase 20202
Cytochrome P450 1A20101
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40202
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0202
Polyunsaturated fatty acid 5-lipoxygenase0202
Cytochrome P450 2C80101
Cytochrome P450 2D60202
Cytochrome P450 2A60101
Cytochrome P450 2C9 0101
5-hydroxytryptamine receptor 2A0202
Androgen receptor0505
Gamma-aminobutyric acid receptor subunit beta-15308
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta5308
Gamma-aminobutyric acid receptor subunit gamma-25308
Gamma-aminobutyric acid receptor subunit alpha-55308
Gamma-aminobutyric acid receptor subunit alpha-35308
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60101
Carbonic anhydrase 40214
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-15308
Gamma-aminobutyric acid receptor subunit alpha-25308
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40203
Gamma-aminobutyric acid receptor subunit alpha-45308
Gamma-aminobutyric acid receptor subunit gamma-35308
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-65308
Adenosine receptor A2a0202
5-hydroxytryptamine receptor 2B0202
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Cytochrome P450 2C190101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Carbonic anhydrase 5A, mitochondrial0215
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit alpha-15308
Gamma-aminobutyric acid receptor subunit beta-35308
Gamma-aminobutyric acid receptor subunit beta-25308
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70202
Carbonic anhydrase 90215
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit5308
Canalicular multispecific organic anion transporter 10303
Carbonic anhydrase 40202
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon5308
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Cruzipain1001
Luciferase4004
estrogen nuclear receptor alpha5005
G4004
peroxisome proliferator activated receptor gamma4004
lysosomal alpha-glucosidase preproprotein1001
mitogen-activated protein kinase 14004
cytochrome P450 3A4 isoform 15005
lamin isoform A-delta105005
Interferon beta5005
HLA class I histocompatibility antigen, B alpha chain 4004
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit beta-21001
Thromboxane A2 receptor 0001
Endothelin-1 receptor0101
Type-1B angiotensin II receptor0101
Type-1 angiotensin II receptor0203
Type-2 angiotensin II receptor0101
Potassium voltage-gated channel subfamily H member 20404
Sodium/bile acid cotransporter0202
Inositol hexakisphosphate kinase 14004
Multidrug and toxin extrusion protein 10404
Leukotriene B4 receptor 20011
cytochrome P450 2C9, partial4004
Chain A, Estrogen-related receptor gamma0011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
acetylcholinesterase3003
glp-1 receptor, partial4004
RAR-related orphan receptor gamma3003
GLS protein4004
TDP1 protein4004
AR protein3003
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
progesterone receptor3003
farnesoid X nuclear receptor3003
pregnane X nuclear receptor3003
cytochrome P450 2D64004
peroxisome proliferator-activated receptor delta3003
caspase-31001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
potassium voltage-gated channel subfamily H member 2 isoform d2002
thyroid hormone receptor beta isoform 24004
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 12002
Voltage-dependent calcium channel gamma-2 subunit3003
GTPase KRas0011
Estrogen receptor0639
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Cellular tumor antigen p533003
Aldo-keto reductase family 1 member B10606
Androgen receptor0203
Polyunsaturated fatty acid lipoxygenase ALOX150404
Glutamate receptor 23003
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent serotonin transporter0404
5-hydroxytryptamine receptor 60405
Nuclear receptor ROR-gamma2002
Estrogen-related receptor gamma0112
Sodium-dependent dopamine transporter 0606
GTP-binding protein Rheb0011
Estrogen receptor beta0538
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, Ferritin light chain4004
interleukin 81001
15-lipoxygenase, partial3003
hypoxia-inducible factor 1 alpha subunit1001
ATAD5 protein, partial3003
USP1 protein, partial2002
Microtubule-associated protein tau2002
Smad32002
aldehyde dehydrogenase 1 family, member A12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
regulator of G-protein signaling 42002
67.9K protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH12002
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)1001
cellular tumor antigen p53 isoform a3003
vitamin D3 receptor isoform VDRA2002
heat shock protein beta-11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
serine/threonine-protein kinase PLK11001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear receptor ROR-gamma isoform 12002
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lethal factor (plasmid)2002
neuropeptide S receptor isoform A1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
5-hydroxytryptamine receptor 40606
Nuclear receptor subfamily 1 group I member 20101
Glucocorticoid receptor0203
Integrin beta-33104
Tyrosine-protein kinase Fyn0303
Glycine receptor subunit alpha-10202
Integrin alpha-IIb3104
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10404
D(2) dopamine receptor0303
Alpha-1B adrenergic receptor0303
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Glycine receptor subunit beta0202
Substance-K receptor0202
D(1A) dopamine receptor0202
Acetylcholinesterase0101
Glycine receptor subunit alpha-20202
Prostaglandin G/H synthase 10202
Glycine receptor subunit alpha-30202
Thromboxane-A synthase 0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0505
5-hydroxytryptamine receptor 2C0606
Adenosine receptor A2a0404
Adenosine receptor A10404
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Vasopressin V1a receptor0202
Alpha-synuclein1001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0303
Histamine H2 receptor3003
Spike glycoprotein3003
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 12002
Aldehyde oxidase0202
TAR DNA-binding protein 431102
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140202
Broad substrate specificity ATP-binding cassette transporter ABCG20304
Cysteinyl leukotriene receptor 10202
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Transthyretin0011
Chain A, Transthyretin0011
acid sphingomyelinase1001
BRCA11001
SMAD family member 21001
PPM1D protein2002
SMAD family member 31001
Thrombopoietin2002
EWS/FLI fusion protein4004
Neuraminidase 0101
glucocerebrosidase1001
Parkin2002
P531001
Alpha-mannosidase0101
pyruvate kinase2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor2002
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 31001
glucokinase regulatory protein1001
glycogen synthase kinase-3 beta isoform 10011
DNA polymerase beta1001
flap endonuclease 12002
ras-related protein Rab-9A2002
tyrosine-protein kinase Yes2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
M-phase phosphoprotein 82002
pyruvate kinase PKM isoform b2002
Maltase-glucoamylase, intestinal0202
Steroid hormone receptor ERR20101
Tyrosine-protein kinase ABL10101
Epidermal growth factor receptor0202
Pancreatic triacylglycerol lipase0101
Triosephosphate isomerase0101
Transthyretin0101
Sex hormone-binding globulin0011
Cyclin-dependent kinase 10101
ATP-dependent translocase ABCB10112
Ornithine decarboxylase2002
Sialidase0101
Solute carrier family 2, facilitated glucose transporter member 10101
Tyrosinase0101
Steroid hormone receptor ERR10101
Aromatase0101
Cyclin-dependent kinase 40101
Ornithine decarboxylase0101
Proto-oncogene tyrosine-protein kinase Src0101
Cystic fibrosis transmembrane conductance regulator0011
17-beta-hydroxysteroid dehydrogenase type 10101
Solute carrier family 2, facilitated glucose transporter member 40101
G2/mitotic-specific cyclin-B10101
Dipeptidyl peptidase 40101
Aldo-keto reductase family 1 member B10101
Protein kinase C alpha type0101
cAMP-dependent protein kinase catalytic subunit alpha0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] A 0101
G1/S-specific cyclin-D10101
Cruzipain0101
DNA (cytosine-5)-methyltransferase 10101
Amine oxidase [flavin-containing] B0101
Proteasome subunit beta type-50101
Substance-P receptor0101
RAC-alpha serine/threonine-protein kinase0101
Cystic fibrosis transmembrane conductance regulator0011
Testosterone 17-beta-dehydrogenase 30101
17-beta-hydroxysteroid dehydrogenase type 20101
Acetylcholinesterase0101
Alpha-glucosidase MAL320101
Signal transducer and activator of transcription 30101
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ABL20101
Tyrosine-protein kinase SYK0101
Dual specificity mitogen-activated protein kinase kinase 40101
Quinone oxidoreductase0001
Xanthine dehydrogenase/oxidase0101
Cytoplasmic tyrosine-protein kinase BMX0101
Death-associated protein kinase 10101
Mitogen-activated protein kinase 100101
Oxysterols receptor LXR-beta0101
Amine oxidase [flavin-containing] B0101
Xanthine dehydrogenase/oxidase0101
MO15-related protein kinase Pfmrk 0101
Oxysterols receptor LXR-alpha0101
Tissue alpha-L-fucosidase0101
Substance-K receptor0101
Integrase 0202
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
ATPase family AAA domain-containing protein 51001
Ataxin-22002
Prenyltransferase homolog0001
Carboxylic ester hydrolase 0101
Solute carrier organic anion transporter family member 1B30404
Dipeptidyl peptidase 30101
DNA (cytosine-5)-methyltransferase 3-like0101
Sialidase-20101
DNA (cytosine-5)-methyltransferase 3A0101
Solute carrier organic anion transporter family member 1B10202
histone acetyltransferase KAT2A isoform 12002
Solute carrier family 22 member 20303
Solute carrier family 22 member 1 0303
Dihydrofolate reductase0101
Solute carrier family 22 member 10001
Chain A, Probable serine/threonine-protein kinase pknB0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
dopamine D1 receptor1001
WRN1001
Fumarate hydratase1001
NFKB1 protein, partial1001
apical membrane antigen 1, AMA11001
DNA polymerase III, partial1001
hypothetical protein, conserved1001
nonstructural protein 10101
LANA0001
polyprotein1001
phospholipase A2, group III0101
cytochrome P450 2D6 isoform 11001
interferon gamma precursor0001
atrial natriuretic peptide receptor 1 precursor1001
histone-lysine N-methyltransferase NSD2 isoform 10001
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 21001
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
protein AF-9 isoform a0001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
rac GTPase-activating protein 1 isoform a0101
DNA polymerase kappa isoform 11001
Vpr1001
muscarinic acetylcholine receptor M11001
DNA repair protein RAD52 homolog isoform a0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Solute carrier family 22 member 30202
Glycoprotein hormones alpha chain1001
Receptor tyrosine-protein kinase erbB-20101
Amyloid-beta precursor protein1001
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Proto-oncogene tyrosine-protein kinase ROS0101
DNA topoisomerase 2-alpha0102
Angiotensin-converting enzyme0202
DNA topoisomerase 20001
Casein kinase II subunit alpha'0101
Multidrug resistance-associated protein 1 0101
Guanine nucleotide-binding protein G1001
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
DNA topoisomerase 2-beta0001
Tyrosine-protein kinase BTK0101
NEDD8-activating enzyme E1 regulatory subunit0011
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20202
Casein kinase II subunit alpha 30101
NEDD8-activating enzyme E1 catalytic subunit0011
Single-stranded DNA cytosine deaminase1001
P2Y purinoceptor 120101
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
ATP-dependent phosphofructokinase1001
5-hydroxytryptamine receptor 3E0113
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 3B0113
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0101
Muscarinic acetylcholine receptor M20101
Neuronal acetylcholine receptor subunit beta-20202
Beta-1 adrenergic receptor0101
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Interleukin-6 receptor subunit alpha0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
5-hydroxytryptamine receptor 3A0101
D(1B) dopamine receptor0101
Beta-3 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
D(4) dopamine receptor0101
Neuronal acetylcholine receptor subunit beta-40101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Neuronal acetylcholine receptor subunit alpha-30101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 70101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0213
Neuronal acetylcholine receptor subunit alpha-40202
5-hydroxytryptamine receptor 3A0214
Neuronal acetylcholine receptor subunit alpha-70101
5-hydroxytryptamine receptor 70101
Glutamate receptor ionotropic, NMDA 2C0101
Thyrotropin-releasing hormone receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Glycine receptor subunit alpha-40101
5-hydroxytryptamine receptor 4 0101
5-hydroxytryptamine receptor 3D0113
5-hydroxytryptamine receptor 3C0113
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 3B0213
Histamine H3 receptor0101
Sigma non-opioid intracellular receptor 10101
Leukotriene B4 receptor 10101
Nischarin0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]