Page last updated: 2024-12-06

tetrabromobisphenol a diglycidyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tetrabromobisphenol A diglycidyl ether (TBBPA-DGE) is a brominated epoxy resin used as a flame retardant in a wide variety of materials, including plastics, textiles, and electronics. Its synthesis involves the reaction of tetrabromobisphenol A (TBBPA) with epichlorohydrin. TBBPA-DGE is an effective flame retardant due to its ability to release bromine radicals during combustion, which inhibits the flame propagation. However, concerns about the potential environmental and health effects of TBBPA-DGE have led to increasing scrutiny of its use. Studies have shown that TBBPA-DGE can bioaccumulate in the environment and has been linked to endocrine disruption, neurotoxicity, and reproductive effects in animals. Its persistence and potential toxicity have prompted researchers to investigate alternative flame retardants and explore ways to minimize the release of TBBPA-DGE into the environment. TBBPA-DGE is studied extensively due to its widespread use, its potential environmental impact, and the need to develop safer alternatives.'

tetrabromobisphenol A diglycidyl ether: used to provide products with fire-resistant properties; MW 656; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID62250
CHEMBL ID2392655
SCHEMBL ID1104781
MeSH IDM0122333

Synonyms (32)

Synonym
3072-84-2
AC-15231
AH-034/11364124
2-[(2,6-dibromo-4-{1-[3,5-dibromo-4-(2-oxiranylmethoxy)phenyl]-1-methylethyl}phenoxy)methyl]oxirane
2,2-bis(4-glycidyloxy-3,5-dibromophenyl)propane
tetrabromobisphenol a diglycidyl ether
2,2-bis(3',5'-dibromo-4'-glycidoxyfenyl)propan [czech]
2,2'-((1-methylethylidene)bis((2,6-dibromo-4,1-phenylene)oxymethylene))bisoxirane
propane, 2,2-bis(3,5-dibromo-4-(2,3-epoxypropoxy)phenyl)-
einecs 221-346-0
tetrabromobiphenol a diglycidyl ether, 2,2',6,6'-
brn 4767400
2,2',6,6'-tetrabromobisphenol a diglycidyl ether
glycidyl tetrabromodian ether
AKOS000269630
2-[[2,6-dibromo-4-[2-[3,5-dibromo-4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
einecs 271-344-9
2,2'-((1-methylethylidene)bis((3,5-dibromo-4,1-phenylene)oxymethylene))bisoxirane
oxirane, 2,2'-((1-methylethylidene)bis((2,6-dibromo-4,1-phenylene)oxymethylene))bis-
2,2-bis(3',5'-dibromo-4'-glycidoxyfenyl)propan
FT-0609138
2,2'-(((propane-2,2-diylbis(2,6-dibromo-4,1-phenylene))bis(oxy))bis(methylene))bis(oxirane)
F0777-0006
CHEMBL2392655
AKOS016039414
SCHEMBL1104781
2,2'-[(1-methylethylidene)bis[(2,6-dibromo-4,1-phenylene)oxymethylene]]bis[oxirane]
DTXSID0052700
tetrabromobi-sphenol a diglycidyl ether
2-{[2,6-dibromo-4-(2-{3,5-dibromo-4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane
J-018085
tetrabromobisphenol a-diglycidyl ether
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID752867Inhibition of rabbit skeletal muscle sarco/endoplasmic reticulum calcium ATPase assessed as inhibition of ATP hydrolysis by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Structural requirements for inhibitory effects of bisphenols on the activity of the sarco/endoplasmic reticulum calcium ATPase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]