An agonist that binds to and activates somatostatin receptors.
ChEBI ID: 177023
| Member | Definition | Class |
|---|---|---|
| l 779976 | A member of the class of indoles that is (betaS)-beta-methyl-D-tryptophan in which the primary amino group undergoes formal condensation with the carboxy group of 4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylic acid and the carboxy group undegoes formal condensation with the amino group of (1R,3S)-cyclohexane-1,3-diyldimethanamine. It is a selective nonpeptidic agonist of the somatostatin subtype-2 (SST2) receptor with Ki of 0.05 nM. | L-779976 |
| l796778 | A methyl ester resulting from the formal condensation of the carboxy group of N-{[(2S)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl}-D-norleucyl-L-lysine with methanol. It is a partial agonist of somatostatin subtype receptor 3 (Ki = 24 nM) that exhibits anticonvulsant effects. | L-796,778 |
| l803087 | A fluoroindole that is 1H-indole substituted by phenyl, 4-{[(2S)-5-carbamimidamido-1-methoxy-1-oxopentan-2-yl]amino}-4-oxobutyl, fluoro and fluoro groups at positions 2, 3, 5 and 7, respectively. It is a selective nonpeptidic agonist of the somatostatin subtype-4 (SST4) receptor with Ki of 0.7 nM. | L-803087 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.88) | 18.2507 |
| 2000's | 30 (73.17) | 29.6817 |
| 2010's | 7 (17.07) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 57 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 22.3872 | 1 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 56.2341 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 22.3872 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Somatostatin receptor type 1 | Homo sapiens (human) | IC50 | 1.0000 | 3 | 3 |
| Somatostatin receptor type 2 | Homo sapiens (human) | IC50 | 7.0000 | 3 | 3 |
| Somatostatin receptor type 2 | Homo sapiens (human) | Ki | 4.7200 | 1 | 1 |
| Somatostatin receptor type 3 | Homo sapiens (human) | IC50 | 7.0000 | 3 | 3 |
| Somatostatin receptor type 4 | Homo sapiens (human) | IC50 | 0.0042 | 3 | 3 |
| Somatostatin receptor type 4 | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Somatostatin receptor type 5 | Homo sapiens (human) | IC50 | 10.0000 | 3 | 3 |