Compounds > 1,4-cyclohexanedimethanol
Page last updated: 2024-12-05

1,4-cyclohexanedimethanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,4-Cyclohexanedimethanol (CHDM) is a cyclic diol used in the production of polyesters and polyamides. It is synthesized through the hydrogenation of terephthalic acid or dimethyl terephthalate, which involves a multi-step process. CHDM is known for its high melting point, good thermal stability, and excellent mechanical properties. These properties make it a valuable component in engineering plastics and other high-performance materials. Research on CHDM focuses on improving its synthesis methods, exploring its applications in various industries, and developing sustainable alternatives for its production. The compound's importance lies in its versatility and potential to contribute to the development of advanced materials with desirable properties.'

1,4-cyclohexanedimethanol: used as a monomer in the production of polyester resins; RN given refers to cpd with specified locants for dimethanol groups [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7735
CHEMBL ID3185118
SCHEMBL ID297828
SCHEMBL ID130642
SCHEMBL ID27912
SCHEMBL ID13461142
MeSH IDM0080534

Synonyms (116)

Synonym
AC-291
AKOS009031609
unii-7i8476p8p0
47a69y3g5m ,
ai3-26300
unii-47a69y3g5m
1,4-cyclohexanedimethanol, trans-
7i8476p8p0 ,
1,4-cyclohexanedimethanol, trans- (70%) and cis- (30%)
3236-47-3
1,4-cyclohexanedimethanol, cis-
AKOS015833096
trans-1,4-cyclohexanedimethanol
cis-1,4-cyclohexanedimethanol
wln: l6tj a1q d1q
1,4-cyclohexanedimethanol
1,4-dimethylolcyclohexane
nsc44508
1,4-bis(hydroxymethyl)cyclohexane
chdm
105-08-8
nsc-44508
1,4-chidm
cyclohexane-1,4-diyldimethanol
nsc 44508
rikabinol dm
brn 1902271
1,4-cyclohexamethylenebis methylol
einecs 203-268-9
hsdb 5364
cyclohex-1,4-ylenedimethanol
ai3-28853
cyclohexane-1,4-dimethanol
alpha,alpha'-dihydroxy-1,4-dimethylcyclohexane
trans-1,4-bis(hydroxymethyl)cyclohexane
C2234
3236-48-4
[4-(hydroxymethyl)cyclohexyl]methanol
A801149
NCGC00248612-01
tox21_200433
dtxsid9026712 ,
cas-105-08-8
NCGC00257987-01
dtxcid106712
8c3fkr6r1b ,
unii-8c3fkr6r1b
ec 203-268-9
ec-no. 203-268-9
FT-0630062
FT-0606822
(trans-4-hydroxymethylcyclohexyl)methanol
vibracure a 240
eastman verityl ab-1000 diol
1,4-cyclohexadimethanol-
chdm-d
dimethylolcyclohexane
sky chdm
AM84323
SCHEMBL297828
1,4 cyclohexanedimethanol
1,4-cyclohexane dimethanol
1,4-cyclo-hexanedimethanol
1,4-dihydroxymethylcyclohexane
1,4-cyclohexane-dimethanol
1,4 cyclohexane dimethanol
1,4-bis-(hydroxymethyl)-cyclohexane
SCHEMBL130642
[(1r,4r)-4-(hydroxymethyl)cyclohexyl]methanol
SCHEMBL27912
1,4-cyclohexanedimethanol, (z)-
cis-1,4-bis(hydroxymethyl)cyclohexane
SCHEMBL13461142
J-500355
(1r,4r)-cyclohexane-1,4-diyldimethanol
trans-cyclohexane-1,4-diyldimethanol
trans-(4-hydroxymethyl-cyclohexyl)-methanol
trans-1,4-dihydroxymethylcyclohexane
trans-cyclohexane-1,4-dimethanol
trans-1,4-cyclohexane dimethanol
trans-chdm
chdm, cis
cis-chdm
1,4-cyclohexanedimethanol,c&t
ean 087583
chdm, trans isomer
cyclohex-1,4-ylenedimethanol, trans
(4-hydroxymethylcyclohexyl)methanol
1,4-bis(hydroxymethyl)cyclohexane,c&t
pm 1597
1,4-cyclohexanedimethanol, cis
1,4-cyclohexanedimethanol, trans
cyclohexane-1,4-dimethanol,c&t
cis-cyclohexane-1,4-diyldimethanol
W-108794
CHEMBL3185118
AKOS028109404
mfcd00066360
1,4-cyclohexanedimethanol, cis + trans
mfcd00001512
DTXSID00274143
DTXSID60274144
SY024459
AS-18294
Q1064929
SB17942
AMY698
(z)-1,4-cyclohexanedimethanol
Q27268338
Q27259032
CS-W016379
EN300-19999
EN300-1721997
F87287
AT36023
Z104476328
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency61.62820.001723.839378.1014AID743083
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.24 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index42.91 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethylene glycol
Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.. ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.. ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.		2.1110ethanediol;
glycol		metabolite;
mouse metabolite;
solvent;
toxin
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.		2.0710methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0710aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		2.0510aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
bisphenol a
4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.		2.0510bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
terephthalic acid
terephthalic acid: RN given refers to 1,4-benzenedicarboxylic acid. terephthalic acid : A benzenedicarboxylic acid carrying carboxy groups at positions 1 and 4. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and isophthalic acids.		2.1110benzenedicarboxylic acid
tetrahydrofuran
oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.		2.0710cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
diglycolic acid
diglycolic acid: nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells		2.0710dicarboxylic acid
dimethyl 4-phthalate
dimethyl 4-phthalate: solvent; structure. dimethyl terephthalate : A diester resulting from the formal condensation of the carboxy groups of terephthalic acid with methanol. It is a primary ingredient widely used in the manufacture of polyesters and industrial plastics.		2.4920diester;
methyl ester;
phthalate ester
alkenes
[no description available]		2.1710
2,2,3,3-tetramethylcyclopropane carboxamide
2,2,3,3-tetramethylcyclopropane carboxamide: structure in first source		2.0710
sesquiterpenes
[no description available]		2.1710
platencin
platencin: inhibits both FabF and FabH; structure in first source. platencin : A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.		2.0510aromatic amide;
cyclic ketone;
dihydroxybenzoic acid;
monocarboxylic acid amide;
polycyclic cage		antibacterial agent;
antimicrobial agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110