Compounds > 4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl
Page last updated: 2024-09-24

4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl

Description

4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID105101
CHEMBL ID311000
CHEBI ID34220
SCHEMBL ID2279047
MeSH IDM0389845

Synonyms (26)

Synonym
BIDD:ER0191
CHEMBL311000 ,
chebi:34220 ,
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl
(1,1'-biphenyl)-4-ol, 2',3',4',5'-tetrachloro-
4'-hydroxy-2,3,4,5-tetrachlorobiphenyl
2,3,4,5-tetrachloro-4'-biphenylol
67651-34-7
[1,1'-biphenyl]-4-ol, 2',3',4',5'-tetrachloro-
[1,1'-biphenyl]-4-ol, 2',3',4',5'-tetrachloro- (9ci)
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
2',3',4',5'-tetrachloro-4-biphenylol
2',3',4',5'-tetrachloro-(1,1'-biphenyl)-4-ol
2',3',4',5'-tetrachlorobiphenyl-4-ol
oh-pcb-61
ccris 9184
4-(2,3,4,5-tetrachlorophenyl)phenol
bdbm50410496
unii-lh750s39fx
lh750s39fx ,
SCHEMBL2279047
DTXSID5022350
AKOS032948983
Q27115915
2',3',4',5'-tetrachloro-4-biphenylol (oh-pcb-61)
PD015520

Drug Classes (2)

ClassDescription
biphenylsBenzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
tetrachlorobenzeneAny member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)16.21810.00101.979414.1600AID255211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID161430Displacement of [125I]thyroxin from human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
AID161431Thyroxine binding constant on human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID230635KPCB/ K352 ratio of the compound1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161427Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T41986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161428Concentration at which 50% total binding against prealbumin protein occurs1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
thyroxine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		mitogen
thyroxine[no description available]medium102-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine		antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
diphenyl[no description available]medium20aromatic fungicide;
benzenes;
biphenyls		antifungal agrochemical;
antimicrobial food preservative
3,3',5'-triiodothyronine[no description available]medium10iodothyroninehuman metabolite
2,2',6,6'-tetrachlorobiphenyl[no description available]medium20
3,4,5,3',4',5'-hexachlorobiphenyl[no description available]medium20hexachlorobiphenyl;
trichlorobenzene
kc 400[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]medium30dichlorobenzene;
hydroxybiphenyls
4-hydroxy-2',4',6'-trichlorobiphenyl[no description available]medium40biphenyls;
trichlorobenzene
2,4,6-triiodophenol[no description available]medium10
chlordecone[no description available]medium10cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant
hexachlorocyclohexane[no description available]medium10chlorocyclohexane
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
2,4,5-trichlorophenoxyacetic acid[no description available]medium10chlorophenoxyacetic acid;
trichlorobenzene		defoliant;
phenoxy herbicide;
synthetic auxin
4-nonylphenol[no description available]medium10phenolsenvironmental contaminant
clomiphene[no description available]medium10tertiary amineestrogen antagonist;
estrogen receptor modulator
dichlorodiphenyl dichloroethylene[no description available]medium10chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt[no description available]medium10benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
benzophenone[no description available]medium10benzophenonesphotosensitizing agent;
plant metabolite
endosulfan[no description available]medium10cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
heptachlor[no description available]medium10cyclodiene organochlorine insecticideagrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant
methoxychlor[no description available]medium10organochlorine insecticide
nafoxidine[no description available]medium10benzenes;
naphthalenes;
ring assembly
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
prednisolone[no description available]medium1011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
estriol[no description available]medium1016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
androsterone[no description available]medium1017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
17-desoxyestradiol[no description available]medium103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
ethinyl estradiol[no description available]medium1017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
chlordan[no description available]medium10cyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
testosterone propionate[no description available]medium10steroid ester
methyltestosterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
norethindrone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
norethynodrel[no description available]medium10oxo steroid
medroxyprogesterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
dichlorodiphenyldichloroethane[no description available]medium10chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
bisphenol a[no description available]medium30bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
p-tert-amylphenol[no description available]medium10alkylbenzene
2-sec-butylphenol[no description available]medium10phenols
4-phenylphenol[no description available]medium10hydroxybiphenyls
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
butylphen[no description available]medium10phenolsallergen
methylparaben[no description available]medium10parabenantifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite
monobenzone[no description available]medium10benzyl etherallergen;
dermatologic drug;
melanin synthesis inhibitor
3-chlorophenol[no description available]medium10monochlorophenol
2,4-dihydroxybenzophenone[no description available]medium10benzophenones
cyproterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
epitestosterone[no description available]medium1017alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen antagonist;
human metabolite
flavanone[no description available]medium10flavanones
androstenediol[no description available]medium1017beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid		androgen;
human metabolite;
mouse metabolite;
radiation protective agent
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
flavone[no description available]medium10flavonesmetabolite;
nematicide
4-cumylphenol[no description available]medium10diarylmethane
o,p'-ddt[no description available]medium10diarylmethane
4-hydroxybenzophenone[no description available]medium10benzophenones
4-chloro-2-cresol[no description available]medium10monochlorobenzenes;
phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
2,4,2',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
ac 45594[no description available]medium10aromatic ether
promegestone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
2,4'-dichlorobiphenyl[no description available]medium10dichlorobiphenyl;
monochlorobenzenes
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol[no description available]medium10stilbenoid
taleranol[no description available]medium10macrolide
bisphenol b[no description available]medium10bisphenol
alfatradiol[no description available]medium1017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
4,4'-Dihydroxybenzophenone[no description available]medium10benzophenones
6-hydroxyflavone[no description available]medium10hydroxyflavonoid
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane[no description available]medium20bisphenol
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]medium10diarylmethane
equol[no description available]medium10hydroxyisoflavans
androstan-3-ol[no description available]medium103-hydroxy steroidandrogen
3,3'-Dihydroxyhexestrol[no description available]medium10stilbenoid
Zearalanone[no description available]medium10macrolide;
resorcinols
4-androstene-3,17-diol[no description available]medium103-hydroxy steroidandrogen
4'-hydroxyflavanone[no description available]medium104'-hydroxyflavanones;
monohydroxyflavanone
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene[no description available]medium10diarylmethane
2-hydroxyestradiol[no description available]medium1017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
mibolerone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid		anabolic agent;
androgen
metribolone[no description available]medium1017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
diethylstilbestrol[no description available]medium20olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
chalcone[no description available]medium10chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
isoeugenol[no description available]medium10isoeugenol
tamoxifen[no description available]medium30stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
6-hydroxyflavanone[no description available]medium10monohydroxyflavanonefungal xenobiotic metabolite
dimethylstilbestrol[no description available]medium10stilbenoid
genistein[no description available]medium207-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
coumestrol[no description available]medium10coumestans;
delta-lactone;
polyphenol		anti-inflammatory agent;
antioxidant;
plant metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
4-hydroxyestradiol[no description available]medium104-hydroxy steroidmetabolite
4-hydroxychalcone[no description available]medium10chalcones;
phenols		antihypertensive agent;
plant metabolite
4'-hydroxychalcone[no description available]medium10chalcones;
phenols		anti-inflammatory agent;
antineoplastic agent
4,4'-dihydroxystilbene[no description available]medium10stilbene-4,4'-diol
4-hydroxystilbene[no description available]medium10stilben-4-ol
4-tert-octylphenol[no description available]medium20alkylbenzene
3,4,3',4'-tetrachlorobiphenyl[no description available]medium20dichlorobenzene;
tetrachlorobiphenyl
afimoxifene[no description available]medium10phenols;
tertiary amino compound		antineoplastic agent;
estrogen receptor antagonist;
metabolite
fulvestrant[no description available]medium1017beta-hydroxy steroid;
3-hydroxy steroid;
organofluorine compound;
sulfoxide		antineoplastic agent;
estrogen antagonist;
estrogen receptor antagonist
bay h 4502[no description available]low00biphenyls;
imidazoles
candesartan cilexetil[no description available]low00biphenyls
4-biphenylylacetic acid[no description available]low00biphenyls;
monocarboxylic acid		non-steroidal anti-inflammatory drug
fenbufen[no description available]low004-oxo monocarboxylic acid;
biphenyls		non-steroidal anti-inflammatory drug
3,3'-dichlorobenzidine[no description available]low00biphenyls;
monochlorobenzenes;
organochlorine compound
3,3'-diaminobenzidine[no description available]low00biphenyls;
substituted aniline		histological dye
benzidine[no description available]low00biphenyls;
substituted aniline		carcinogenic agent
4-nitrobiphenyl[no description available]low00biphenyls
dianisidine[no description available]low00biphenyls
2-tolidine[no description available]low00biphenyls
n,n'-diacetylbenzidine[no description available]low00biphenyls
2-amino-4-phenylphenol[no description available]low00biphenyls
4-acetylaminobiphenyl[no description available]low00biphenyls
4-biphenylylacetic acid ethyl ester[no description available]low00biphenyls
brequinar[no description available]low00biphenyls;
monocarboxylic acid;
monofluorobenzenes;
quinolinemonocarboxylic acid		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor;
immunosuppressive agent;
pyrimidine synthesis inhibitor
tasosartan[no description available]low00biphenyls
telmisartan[no description available]low00benzimidazoles;
biphenyls;
carboxybiphenyl		angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic
clobuzarit[no description available]low00biphenyls;
organochlorine compound
magnolol[no description available]low00biphenyls
honokiol[no description available]low00biphenyls
bitertanol[no description available]low00aromatic ether;
biphenyls;
secondary alcohol;
triazoles
isodiospyrin[no description available]low00biphenyls
difenpiramide[no description available]low00biphenyls;
monocarboxylic acid amide;
pyridines		antipyretic;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
2-(4-phenylphenoxy)propanoic acid[no description available]low00biphenyls
dityrosine[no description available]low00biphenyls;
non-proteinogenic alpha-amino acid;
tyrosine derivative		biomarker
4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl[no description available]low00biphenyls;
dichlorobenzene;
sulfone
nitroflurbiprofen[no description available]low00biphenyls;
carboxylic ester;
nitrate ester;
organofluorine compound		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
geroprotector;
non-steroidal anti-inflammatory drug;
vasodilator agent
olmesartan medoxomil[no description available]low00biphenyls
4'-hydroxyflurbiprofen[no description available]low00biphenyls
dehydrodieugenol[no description available]low00biphenyls
bifeprunox[no description available]low00biphenyls
2-chloro-n-(4-chlorobiphenyl-2-yl)nicotinamide[no description available]low00anilide fungicide;
biphenyls;
monochlorobenzenes;
pyridinecarboxamide		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
environmental contaminant;
xenobiotic
aucuparin[no description available]low00biphenyls
2-[(3,4-dimethoxyphenyl)methyl]-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole[no description available]low00biphenyls
2-(2,5-dimethoxyphenyl)-5-[4-(4-methoxyphenyl)phenyl]-1,3,4-oxadiazole[no description available]low00biphenyls
(2'-(benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamide)[no description available]low00biphenyls
4-phenylbenzoic acid (propan-2-ylideneamino) ester[no description available]low00biphenyls
N-[[(6-methyl-2-pyridinyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide[no description available]low00biphenyls
4-phenyl-N-(2-propyl-5-tetrazolyl)benzamide[no description available]low00biphenyls
2-[(1-methyl-5-tetrazolyl)thio]-N-(2-phenylphenyl)acetamide[no description available]low00biphenyls
3-phenyl-5-(2-phenylphenyl)-1,2,4-oxadiazole[no description available]low00biphenyls
N-[[methyl-(phenylmethyl)amino]-sulfanylidenemethyl]-4-phenylbenzamide[no description available]low00biphenyls
N-[4-[4-(ethylsulfonylamino)-3-methoxyphenyl]-2-methoxyphenyl]ethanesulfonamide[no description available]low00biphenyls
urb 597[no description available]low00biphenyls
3-(4-phenylphenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine[no description available]low00biphenyls
ac 55649[no description available]low00biphenyls;
carboxybiphenyl
1-[3-(4-phenylphenoxy)propyl]-1,2,4-triazole[no description available]low00biphenyls
N-[2-(2-phenylphenoxy)ethyl]-2-furancarboxamide[no description available]low00biphenyls
2-(2-phenylanilino)-N-(phenylmethyl)acetamide[no description available]low00biphenyls
4-(2-fluorophenyl)-N-(2-methylbut-3-yn-2-yl)benzamide[no description available]low00biphenyls
5-oxo-3-(4-phenylphenyl)-2H-furan-4-carbonitrile[no description available]low00biphenyls
N-([biphenyl]-2-yl)-3-cyclopentylpropanamide[no description available]low00biphenyls;
cyclopentanes;
secondary carboxamide
1-(4-morpholinyl)-2-(4-phenylphenoxy)-1-propanone[no description available]low00biphenyls
2-(4-morpholinyl)-N-(2-phenylphenyl)propanamide[no description available]low00biphenyls
4-[4-[2-hydroxy-3-(4-morpholinyl)propoxy]phenyl]benzonitrile[no description available]low00biphenyls;
nitrile
3-[4-[(2-hydroxy-5-phenylphenyl)methyl]-1-piperazinyl]propanenitrile[no description available]low00biphenyls
N-(2-methoxyethyl)-4-[4-(2-methoxyethylsulfamoyl)phenyl]benzenesulfonamide[no description available]low00biphenyls
2-phenylbutanoic acid [2-oxo-2-(2-phenylanilino)ethyl] ester[no description available]low00biphenyls
2-(4-benzoyl-1-piperazinyl)-N-(2-phenylphenyl)propanamide[no description available]low00biphenyls
fexaramine[no description available]low00biphenyls
alx 5407[no description available]low00biphenyls
bay 12-9566[no description available]low00biphenyls;
organochlorine compound
sacubitril[no description available]low00biphenyls
biphenyl-indanone a[no description available]low00biphenyls
fimasartan[no description available]low00biphenyls
2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid[no description available]low00biphenyls;
organobromine compound
l-161982[no description available]low00biphenyls
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide[no description available]low001,3,4-oxadiazoles;
benzamides;
biphenyls;
nitrile		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
abt-737[no description available]low00aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide[no description available]low00biphenyls
ly2183240[no description available]low00biphenyls
fluxapyroxad[no description available]low00anilide fungicide;
aromatic amide;
biphenyls;
pyrazoles;
trifluorobenzene		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
(3R,3aS,7R,7aS)-3-[4-[4-(dimethylamino)phenyl]-2-fluorophenyl]-7-methyl-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one[no description available]low00biphenyls
3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide[no description available]low00biphenyls
WWL113[no description available]low00biphenyls
lde225[no description available]low00aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
N-[3-(3-chlorophenyl)phenyl]-1-(3-isoxazolylmethyl)-4-piperidinecarboxamide[no description available]low00biphenyls;
organochlorine compound
N-[3-(3-chlorophenyl)phenyl]-1-(3-oxolanylmethyl)-4-piperidinecarboxamide[no description available]low00biphenyls;
organochlorine compound
4-(4-acetyloxyphenyl)benzoic acid [2-[[2-(2-chloroanilino)-2-oxoethyl]-methylamino]-2-oxoethyl] ester[no description available]low00biphenyls
N-cyclopropyl-3-{4-[(cyclopropylmethyl)carbamoyl]phenyl}-4-methylbenzamide[no description available]low00benzamides;
biphenyls;
cyclopropanes;
dicarboxylic acid diamide		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
tak-875[no description available]low00biphenyls
bms-790052[no description available]low00biphenyls;
carbamate ester;
carboxamide;
imidazoles;
valine derivative		antiviral drug;
nonstructural protein 5A inhibitor
(2S)-2-[[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-6-purinyl]amino]-3-phenyl-1-propanol[no description available]low00biphenyls
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine[no description available]low00biphenyls;
thienopyrimidine
ml228 probe[no description available]low001,2,4-triazines;
biphenyls;
pyridines;
secondary amino compound		hypoxia-inducible factor pathway activator
a 769662[no description available]low00biphenyls
1,2,4,5-tetrachlorobenzene[no description available]low00tetrachlorobenzene
tetrachlorophthalic anhydride[no description available]low00cyclic dicarboxylic anhydride;
tetrachlorobenzene		allergen;
cross-linking reagent
tecnazene[no description available]low00aromatic fungicide;
C-nitro compound;
tetrachlorobenzene		antifungal agrochemical
1,2,3,4-tetrachlorobenzene[no description available]low00tetrachlorobenzene
1,2,3,5-tetrachlorobenzene[no description available]low00tetrachlorobenzene
3,4,5,6-tetrachlorocatechol[no description available]low00chlorocatechol;
tetrachlorobenzene
tetrachloroisophthalonitrile[no description available]low00aromatic fungicide;
dinitrile;
tetrachlorobenzene		antifungal agrochemical
4,5,6,7-tetrachlorophthalide[no description available]low00gamma-lactone;
organic heterobicyclic compound;
propan-1-ol;
tetrachlorobenzene		antifungal agrochemical;
melanin synthesis inhibitor
2,3,4,5-tetrachlorobiphenyl[no description available]low00tetrachlorobenzene;
tetrachlorobiphenyl
2,3,5,6-tetrachlorobiphenyl[no description available]low00tetrachlorobenzene;
tetrachlorobiphenyl
2,3,3',4,4',5-hexachlorobiphenyl[no description available]low00dichlorobenzene;
hexachlorobiphenyl;
tetrachlorobenzene
2,3,4,5,3',4',5'-heptachlorobiphenyl[no description available]low00heptachlorobiphenyl;
tetrachlorobenzene;
trichlorobenzene
2,3,4,4'5-pentachlorobiphenyl[no description available]low00monochlorobenzenes;
pentachlorobiphenyl;
tetrachlorobenzene
2,3,5,6-tetrachlorohydroquinone[no description available]low00chlorohydroquinones;
tetrachlorobenzene
ConditionIndicatedRelationship StrengthStudiesTrials
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Cancer of Breast0low10
Cancer of the Breast0low10
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Tubular0low10
Hormone-Dependent Neoplasms0low10
Human Mammary Carcinoma0low10
Malignant Neoplasm of Breast0low10
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Neoplasms, Breast0low10
Neoplasms, Hormone-Dependent0low10
Tumors, Breast0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]