Page last updated: 2024-12-07

4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl, also known as 4-OH-TCB, is a hydroxylated polychlorinated biphenyl (PCB) congener. It is a persistent organic pollutant (POP) that has been detected in the environment and in biological samples. 4-OH-TCB is formed through the metabolic breakdown of PCBs in the environment and in living organisms. It is known to be a potent endocrine disruptor and can interfere with the function of hormones such as estrogen. Studies have shown that 4-OH-TCB can accumulate in the food chain, particularly in fatty tissues, and may pose health risks to humans and wildlife. Research on 4-OH-TCB focuses on understanding its environmental fate, toxicological effects, and potential for bioaccumulation. The compound is studied to assess its potential impact on human health and ecosystems and to develop strategies for reducing its environmental burden.'
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4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID105101
CHEMBL ID311000
CHEBI ID34220
SCHEMBL ID2279047
MeSH IDM0389845

Synonyms (26)

Synonym
BIDD:ER0191
CHEMBL311000 ,
chebi:34220 ,
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl
(1,1'-biphenyl)-4-ol, 2',3',4',5'-tetrachloro-
4'-hydroxy-2,3,4,5-tetrachlorobiphenyl
2,3,4,5-tetrachloro-4'-biphenylol
67651-34-7
[1,1'-biphenyl]-4-ol, 2',3',4',5'-tetrachloro-
[1,1'-biphenyl]-4-ol, 2',3',4',5'-tetrachloro- (9ci)
4-hydroxy-2',3',4',5'-tetrachlorobiphenyl
2',3',4',5'-tetrachloro-4-biphenylol
2',3',4',5'-tetrachloro-(1,1'-biphenyl)-4-ol
2',3',4',5'-tetrachlorobiphenyl-4-ol
oh-pcb-61
ccris 9184
4-(2,3,4,5-tetrachlorophenyl)phenol
bdbm50410496
unii-lh750s39fx
lh750s39fx ,
SCHEMBL2279047
DTXSID5022350
AKOS032948983
Q27115915
2',3',4',5'-tetrachloro-4-biphenylol (oh-pcb-61)
PD015520

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Therefore, our aim was to evaluate in vitro toxic effects of hydroxylated PCB (PCB-22; 2',3',4',5'-tetrachloro-4-biphenylol) and PCB congener (PCB-77; 3,3',4,4'-tetrachlorobiphenyl) on Sertoli cells isolated from 19- to 21-day-old male rats."( Toxic effects of polychlorinated biphenyls on cultured rat Sertoli cells.
Finlay, MF; Flowers, AF; Millette, CF; Raychoudhury, SS,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
biphenylsBenzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
tetrachlorobenzeneAny member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)16.21810.00101.979414.1600AID255211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID161430Displacement of [125I]thyroxin from human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
AID161431Thyroxine binding constant on human plasma prealbumin.1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID230635KPCB/ K352 ratio of the compound1986Journal of medicinal chemistry, Dec, Volume: 29, Issue:12
A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
AID161427Relative binding affinity to prealbumin was determined from the competition binding assays and is expressed relative to L-T41986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
AID161428Concentration at which 50% total binding against prealbumin protein occurs1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]