Page last updated: 2024-12-11

zr 777

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ZR 777: juvenile hormone analog; RN given refers to cpd with unspecified isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6434236
CHEMBL ID38226
CHEBI ID39243
SCHEMBL ID43180
SCHEMBL ID2233054
MeSH IDM0097586

Synonyms (51)

Synonym
brn 2108959
einecs 255-898-9
epa pesticide chemical code 107501
enstar
2,4-dodecadienoic acid, 3,7,11-trimethyl-, 2-propynyl ester, (e,e)-
2-kinoprene
xr 777
ent 70531
enstar igr
caswell no. 714aa
kinoprene [ansi]
zr77
(e,e)-3,7,11-trimethyl-2,4-dodecadienoic acid 2-propynyl ester
42588-37-4
(e,e)-2-propynyl 3,7,11-trimethyl-2,4-dodecadienoate
prop-2-yn-1-yl (2e,4e)-3,7,11-trimethyldodeca-2,4-dienoate
2-propynyl (e,e)-3,7,11-trimethyl-2,4-dodecadienoate
kinoprene
CHEBI:39243 ,
zr 777
CHEMBL38226
prop-2-ynyl (2e,4e)-3,7,11-trimethyldodeca-2,4-dienoate
C19042
cas-42588-37-4
tox21_302008
dtxcid1012624
dtxsid3032624 ,
NCGC00255358-01
zr-777
37882-31-8
2-propynyl 3,7,11-trimethyl-2,4-dodecadienoate
kinopren
2,4-dodecadienoic acid, 3,7,11-trimethyl-, 2-propynyl ester
zr-777 5e
kinoprene [ansi:iso]
2,4-dodecadienoic acid, 3,7,11-trimethyl-, 2-propynyl ester, (2e,4e)-
6iw5nlq04r ,
unii-6iw5nlq04r
AKOS015903440
kinoprene [iso]
kinoprene, (+/-)-
xr-777
ent-70531
2,4-dodecadienoic acid, 3,7,11-trimethyl-, 2-propyn-1-yl ester, (2e,4e)
kinoprene [mi]
zr-77
53023-55-5
SCHEMBL43180
SCHEMBL2233054
Q27119786
dimethyl2,5-pyridinedicarboxylate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
juvenile hormone mimicnull
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
farnesane sesquiterpenoid
terminal acetylenic compoundAn acetylenic compound which a carbon of the C#C moiety is attached to a hydrogen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
AR proteinHomo sapiens (human)Potency36.61810.000221.22318,912.5098AID743042; AID743063
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency8.70760.000214.376460.0339AID720692
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency15.35530.003041.611522,387.1992AID1159552
retinoid X nuclear receptor alphaHomo sapiens (human)Potency41.81580.000817.505159.3239AID1159527; AID1159531
estrogen nuclear receptor alphaHomo sapiens (human)Potency76.95880.000229.305416,493.5996AID743079
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID220250Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
AID23280Partition coefficient (logP)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
AID220245Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 14.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index14.65 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (14.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]