Compounds > 3,3'-Dihydroxyhexestrol
Page last updated: 2024-09-24

3,3'-Dihydroxyhexestrol

Cross-References

ID SourceID
PubMed CID97762
CHEMBL ID14702
CHEBI ID34319

Synonyms (29)

Synonym
brn 3417559
pyrocatechol, 4,4'-(meso-1,2-diethylethylene)di-
nsc 35753
pyrocatechol, 4,4'-(1,2-diethylethylene)di-
79199-51-2
nsc-35753
mls002607934 ,
3,3'-dihydroxyhexestrol
4,4'-(1,2-diethylethylene)dipyrocatechol
4,4'-hexane-3,4-diyldibenzene-1,2-diol
chebi:34319 ,
CHEMBL14702
4-[4-(3,4-dihydroxyphenyl)hexan-3-yl]benzene-1,2-diol
smr001526695
HMS3085C09
414r2xfd5w ,
unii-414r2xfd5w
4-[2-(3,4-dihydroxyphenyl)-1-ethyl-butyl]pyrocatechol
bdbm81212
4-[4-[3,4-bis(oxidanyl)phenyl]hexan-3-yl]benzene-1,2-diol
cid_97762
ag-h-17813
4-[2-(3,4-dihydroxyphenyl)-1-ethyl-butyl]benzene-1,2-diol
DTXSID6022503
Q27115986
1,2-benzenediol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (r*,s*)-
1,2-benzenediol, 4,4'-((1r,2s)-1,2-diethyl-1,2-ethanediyl)bis-, rel-
rel-4,4'-((1r,2s)-1,2-diethyl-1,2-ethanediyl)bis(1,2-benzenediol)
3',3''-dihydroxyhexestrol

Drug Classes (1)

ClassDescription
stilbenoidAny olefinic compound characterised by a 1,2-diphenylethylene backbone.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (25)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency79.43280.631035.7641100.0000AID504339
Nrf2Homo sapiens (human)Potency25.11890.09208.222223.1093AID624171
thioredoxin reductaseRattus norvegicus (Norway rat)Potency7.94330.100020.879379.4328AID588453
GLS proteinHomo sapiens (human)Potency35.48130.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency2.37250.000811.382244.6684AID686978; AID686979
Smad3Homo sapiens (human)Potency14.12540.00527.809829.0929AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency25.11890.707912.194339.8107AID720542
regulator of G-protein signaling 4Homo sapiens (human)Potency19.95260.531815.435837.6858AID504845
67.9K proteinVaccinia virusPotency3.16230.00018.4406100.0000AID720579
IDH1Homo sapiens (human)Potency23.10930.005210.865235.4813AID686970
chromobox protein homolog 1Homo sapiens (human)Potency56.23410.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency32.64270.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency10.00003.548119.542744.6684AID743266
flap endonuclease 1Homo sapiens (human)Potency89.12510.133725.412989.1251AID588795
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency29.93490.168316.404067.0158AID720504
DNA polymerase eta isoform 1Homo sapiens (human)Potency79.43280.100028.9256213.3130AID588591
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency17.78280.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency10.32250.004611.374133.4983AID624297
DNA polymerase kappa isoform 1Homo sapiens (human)Potency50.11870.031622.3146100.0000AID588579
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency25.11890.058010.694926.6086AID602310
Glycoprotein hormones alpha chainHomo sapiens (human)Potency11.22024.46688.344810.0000AID624291
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium bergheiIC50 (µMol)67.50000.889021.028671.5000AID504765; AID540252; AID540269
glucose-6-phosphate 1-dehydrogenase isoform bHomo sapiens (human)IC50 (µMol)80.00008.870012.851817.8000AID504792
VifHuman immunodeficiency virus 1IC50 (µMol)6.46000.270034.0015100.0000AID1117319
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)IC50 (µMol)6.46000.270026.3638100.0000AID1117319
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)37.15350.00101.979414.1600AID255211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell population proliferationGlycoprotein hormones alpha chainHomo sapiens (human)
hormone-mediated signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
regulation of signaling receptor activityGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of steroid biosynthetic processGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of cell migrationGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid gland developmentGlycoprotein hormones alpha chainHomo sapiens (human)
luteinizing hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone signaling pathwayGlycoprotein hormones alpha chainHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIGlycoprotein hormones alpha chainHomo sapiens (human)
negative regulation of organ growthGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone secretionGlycoprotein hormones alpha chainHomo sapiens (human)
thyroid hormone generationGlycoprotein hormones alpha chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
protein bindingGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone activityGlycoprotein hormones alpha chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
extracellular regionGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
Golgi lumenGlycoprotein hormones alpha chainHomo sapiens (human)
follicle-stimulating hormone complexGlycoprotein hormones alpha chainHomo sapiens (human)
pituitary gonadotropin complexGlycoprotein hormones alpha chainHomo sapiens (human)
extracellular spaceGlycoprotein hormones alpha chainHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID130587Estrogenic activity in uterotrophic assay in mice at 10 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID135030Inhibition of anti-uterotrophic activity in mice at 25 ug/day (%inhibition=100-(E S,T-EV)x100)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130561Anti-uterotrophic activity in mice at 250 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130593Estrogenic activity in uterotrophic assay in mice at 50 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
AID135031Inhibition of anti-uterotrophic activity in mice at 250 ug/day (%inhibition=100-(E S,T-EV)x100)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130562Anti-uterotrophic activity in mice at 5 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130560Anti-uterotrophic activity in mice at 250 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130591Estrogenic activity in uterotrophic assay in mice at 250 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID135029Inhibition of anti-uterotrophic activity in mice at 100 ug/day (%inhibition=100-(E S,T-EV)x100)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130585Estrogenic activity in uterotrophic assay in mice at 0.4 ug/day with estrone1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID71120Relative binding affinity for calf uterine estrogen receptor by 17-beta-[3H]-estradiol competition.1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130584Estrogenic activity in uterotrophic assay in mice at 0 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID135032Inhibition of anti-uterotrophic activity in mice at 5 ug/day (%inhibition=100-(E S,T-EV)x100)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130559Anti-uterotrophic activity in mice at 100 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130592Estrogenic activity in uterotrophic assay in mice at 50 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
AID130590Estrogenic activity in uterotrophic assay in mice at 2 ug/day1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
Ring-substituted 1,2-dialkylated 1,2-bis(hydroxyphenyl)ethanes. 1. Synthesis and estrogen receptor binding affinity of 2,2'- and 3,3'-disubstituted hexestrols.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
hexestrol[no description available]medium10stilbenoid
chlordecone[no description available]medium10cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant
hexachlorocyclohexane[no description available]medium10chlorocyclohexane
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
2,4,5-trichlorophenoxyacetic acid[no description available]medium10chlorophenoxyacetic acid;
trichlorobenzene		defoliant;
phenoxy herbicide;
synthetic auxin
4-nonylphenol[no description available]medium10phenolsenvironmental contaminant
clomiphene[no description available]medium10tertiary amineestrogen antagonist;
estrogen receptor modulator
dichlorodiphenyl dichloroethylene[no description available]medium10chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt[no description available]medium10benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
benzophenone[no description available]medium10benzophenonesphotosensitizing agent;
plant metabolite
endosulfan[no description available]medium10cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
heptachlor[no description available]medium10cyclodiene organochlorine insecticideagrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant
methoxychlor[no description available]medium10organochlorine insecticide
nafoxidine[no description available]medium10benzenes;
naphthalenes;
ring assembly
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
prednisolone[no description available]medium1011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
estriol[no description available]medium1016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
androsterone[no description available]medium1017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
17-desoxyestradiol[no description available]medium103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
ethinyl estradiol[no description available]medium1017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
chlordan[no description available]medium10cyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
testosterone propionate[no description available]medium10steroid ester
methyltestosterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
norethindrone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
norethynodrel[no description available]medium10oxo steroid
medroxyprogesterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
dichlorodiphenyldichloroethane[no description available]medium10chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
p-tert-amylphenol[no description available]medium10alkylbenzene
2-sec-butylphenol[no description available]medium10phenols
4-phenylphenol[no description available]medium10hydroxybiphenyls
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
butylphen[no description available]medium10phenolsallergen
methylparaben[no description available]medium10parabenantifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite
monobenzone[no description available]medium10benzyl etherallergen;
dermatologic drug;
melanin synthesis inhibitor
3-chlorophenol[no description available]medium10monochlorophenol
2,4-dihydroxybenzophenone[no description available]medium10benzophenones
cyproterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
epitestosterone[no description available]medium1017alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen antagonist;
human metabolite
flavanone[no description available]medium10flavanones
androstenediol[no description available]medium1017beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid		androgen;
human metabolite;
mouse metabolite;
radiation protective agent
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
flavone[no description available]medium10flavonesmetabolite;
nematicide
4-cumylphenol[no description available]medium10diarylmethane
o,p'-ddt[no description available]medium10diarylmethane
4-hydroxybenzophenone[no description available]medium10benzophenones
4-chloro-2-cresol[no description available]medium10monochlorobenzenes;
phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
2,4,2',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
ac 45594[no description available]medium10aromatic ether
promegestone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
2,4'-dichlorobiphenyl[no description available]medium10dichlorobiphenyl;
monochlorobenzenes
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol[no description available]medium10stilbenoid
taleranol[no description available]medium10macrolide
bisphenol b[no description available]medium10bisphenol
alfatradiol[no description available]medium1017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
4,4'-Dihydroxybenzophenone[no description available]medium10benzophenones
6-hydroxyflavone[no description available]medium10hydroxyflavonoid
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane[no description available]medium10bisphenol
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]medium10diarylmethane
equol[no description available]medium10hydroxyisoflavans
androstan-3-ol[no description available]medium103-hydroxy steroidandrogen
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]medium10dichlorobenzene;
hydroxybiphenyls
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl[no description available]medium10biphenyls;
tetrachlorobenzene
Zearalanone[no description available]medium10macrolide;
resorcinols
4-androstene-3,17-diol[no description available]medium103-hydroxy steroidandrogen
4'-hydroxyflavanone[no description available]medium104'-hydroxyflavanones;
monohydroxyflavanone
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene[no description available]medium10diarylmethane
2-hydroxyestradiol[no description available]medium1017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
mibolerone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid		anabolic agent;
androgen
metribolone[no description available]medium1017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
chalcone[no description available]medium10chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
isoeugenol[no description available]medium10isoeugenol
tamoxifen[no description available]medium10stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
6-hydroxyflavanone[no description available]medium10monohydroxyflavanonefungal xenobiotic metabolite
dimethylstilbestrol[no description available]medium10stilbenoid
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
coumestrol[no description available]medium10coumestans;
delta-lactone;
polyphenol		anti-inflammatory agent;
antioxidant;
plant metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
4-hydroxyestradiol[no description available]medium104-hydroxy steroidmetabolite
4-hydroxychalcone[no description available]medium10chalcones;
phenols		antihypertensive agent;
plant metabolite
4'-hydroxychalcone[no description available]medium10chalcones;
phenols		anti-inflammatory agent;
antineoplastic agent
4,4'-dihydroxystilbene[no description available]medium10stilbene-4,4'-diol
4-hydroxystilbene[no description available]medium10stilben-4-ol
diethylstilbestrol[no description available]low00stilbenoid
3,3',4,5'-tetrahydroxystilbene[no description available]low00stilbenoid
sarpogrelate[no description available]low00hemisuccinate;
stilbenoid
2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine[no description available]low00stilbenoid
2-[4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine[no description available]low00stilbenoid
triphenylethylene[no description available]low00stilbenoid
ethamoxytriphetol[no description available]low00stilbenoid
triparanol[no description available]low00stilbenoidanticoronaviral agent
iodoalphionic acid[no description available]low00stilbenoid
norpropoxyphene[no description available]low00stilbenoid
2,3,3-triphenylacrylonitrile[no description available]low00stilbenoid
remacemide[no description available]low00stilbenoid
hexestrol bis(diethylaminoethyl ether)[no description available]low00stilbenoid
tetraphenylcyclopentadienone[no description available]low00stilbenoid
1-(4-hydroxyphenyl)-2-phenylethan-1-one[no description available]low00stilbenoid
o-desmethylangolensin[no description available]low00stilbenoid
4,5-diphenyl-1,5-dihydroimidazol-2-one[no description available]low00stilbenoid
lunularic acid[no description available]low00stilbenoid
lunularin[no description available]low00stilbenoid
diphenidine[no description available]low00stilbenoid
nutlin 3[no description available]low00stilbenoid
1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone[no description available]low00stilbenoid
sc 57666[no description available]low00stilbenoid
lephetamine[no description available]low00stilbenoid
pallidol[no description available]low00carbopolycyclic compound;
polyphenol;
stilbenoid		antifungal agent;
antioxidant;
plant metabolite
1-(4-bromophenyl)-2-phenylethan-1-one[no description available]low00stilbenoid
vedelianin[no description available]low00cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
plant metabolite
2-(2-chloro-6-fluorophenyl)-1-(2,4-dihydroxyphenyl)ethanone[no description available]low00stilbenoid
2-(3,4-dimethoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethanone[no description available]low00stilbenoid
1-(3,4-dimethoxy-2-methylphenyl)-2-(3,4-dimethoxyphenyl)ethanone[no description available]low00stilbenoid
zuclomiphene[no description available]low00stilbenoid
2-(4-bromophenyl)-1-(2,4-dihydroxyphenyl)ethanone[no description available]low00stilbenoid
5-[2-(4-ethoxy-2-hydroxyphenyl)-2-oxoethyl]-2-benzofurancarboxylic acid[no description available]low00stilbenoid
ly 288513[no description available]low00stilbenoid
2-[(4,7-dimethyl-2-quinazolinyl)thio]-1,2-diphenylethanone[no description available]low00stilbenoid
toremifene citrate[no description available]low00stilbenoidanticoronaviral agent
droloxifene[no description available]low00stilbenoid
1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene[no description available]low00stilbenoid
idoxifene[no description available]low00stilbenoid
n-desmethyltoremifene[no description available]low00stilbenoid
desdimethyltamoxifen[no description available]low00stilbenoid
alpha-hydroxytamoxifen[no description available]low00stilbenoid
2-chloro-N-(1,2-diphenylethyl)acetamide[no description available]low00stilbenoid
resveratrol-4'-o-glucuronide[no description available]low00glycoside;
stilbenoid
astringin[no description available]low00beta-D-glucoside;
monosaccharide derivative;
polyphenol;
stilbenoid		antineoplastic agent;
antioxidant;
metabolite
isorhapontin[no description available]low00glycoside;
stilbenoid
trans-2,3',4,5'-tetrahydroxystilbene[no description available]low00stilbenoid
polydatin[no description available]low00beta-D-glucoside;
monosaccharide derivative;
polyphenol;
stilbenoid		anti-arrhythmia drug;
antioxidant;
geroprotector;
hepatoprotective agent;
metabolite;
nephroprotective agent;
potassium channel modulator
Pinosylvin methyl ether[no description available]low00stilbenoid
epsilon-viniferin[no description available]low001-benzofurans;
polyphenol;
stilbenoid		metabolite
salvianolic acid a[no description available]low00stilbenoid
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid[no description available]low00stilbenoid
(+)-trans-epsilon-viniferin[no description available]low001-benzofurans;
polyphenol;
stilbenoid
desoxyrhaponticin[no description available]low00glycoside;
stilbenoid
3,5-dimethoxy-trans-stilbene[no description available]low00stilbenoid
quadrangularin a[no description available]low00indanes;
polyphenol;
stilbenoid		antioxidant;
plant metabolite
isorhapontigenin[no description available]low00stilbenoid
rhapontigenin[no description available]low00stilbenoid
(E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside[no description available]low00beta-D-glucoside;
resorcinols;
stilbenoid		anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
cyclooxygenase 2 inhibitor;
platelet aggregation inhibitor
fosbretabulin[no description available]low00stilbenoid
n-desmethyltamoxifen[no description available]low00stilbenoid
mulberroside a[no description available]low00glycoside;
stilbenoid
cajanine[no description available]low00stilbenoid
metaflumizone[no description available]low00semicarbazone;
stilbenoid
bms453[no description available]low00benzoic acids;
dihydronaphthalenes;
stilbenoid		retinoic acid receptor alpha antagonist;
retinoic acid receptor beta agonist;
retinoic acid receptor gamma antagonist;
teratogenic agent
gw 4064[no description available]low00stilbenoid
bms 204493[no description available]low00acetylenic compound;
benzoic acids;
dihydronaphthalenes;
stilbenoid		retinoic acid receptor antagonist
4-hydroxy-n-desmethyltamoxifen[no description available]low00stilbenoid
delta-viniferin[no description available]low001-benzofurans;
polyphenol;
stilbenoid
palovarotene[no description available]low00stilbenoid
aiphanol[no description available]low00aromatic ether;
benzodioxine;
lignan;
stilbenoid		EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
batatasin-iii[no description available]low00stilbenoid
n-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide[no description available]low00stilbenoid
nutlin-3a[no description available]low00stilbenoid
bay94 9172[no description available]low00(18)F radiopharmaceutical;
aromatic ether;
polyether;
secondary amino compound;
stilbenoid;
substituted aniline		radioactive imaging agent
3-[[(3R,4S)-2-(4-bromophenyl)-5-(3-chlorophenyl)-4-(2-methoxyphenyl)-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinone[no description available]low00stilbenoid
schweinfurthin g[no description available]low00cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		antineoplastic agent;
metabolite
schweinfurthin f[no description available]low00cyclic ether;
organic heterotricyclic compound;
resorcinols;
stilbenoid		metabolite
amorfrutin a[no description available]low00stilbenoid
3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid[no description available]low00stilbenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Inflammation0low10
Innate Inflammatory Response0low10