metformin has been researched along with Keloid in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of Metformin on the proliferation and collagen synthesis of the human keloids fibroblasts as well as the effect on phosphorylation of Akt/FoxO1 signal transduction pathway." | 7.81 | [The effect of Metformin on the proliferation and collagen synthesis of human keloids fibroblasts]. ( Weiyuan, M; Yi, S, 2015) |
| "To investigate the effect of Metformin on the proliferation and collagen synthesis of the human keloids fibroblasts as well as the effect on phosphorylation of Akt/FoxO1 signal transduction pathway." | 3.81 | [The effect of Metformin on the proliferation and collagen synthesis of human keloids fibroblasts]. ( Weiyuan, M; Yi, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hua, Z | 1 |
| Wei, P | 1 |
| Dong, X | 1 |
| Jin, X | 1 |
| Jeon, HB | 1 |
| Roh, H | 1 |
| Ahn, HM | 1 |
| Lee, JH | 1 |
| Yun, CO | 1 |
| Roh, TS | 1 |
| Lee, WJ | 1 |
| Lei, R | 1 |
| Zhang, S | 1 |
| Wang, Y | 1 |
| Dai, S | 1 |
| Sun, J | 1 |
| Zhu, C | 1 |
| Yi, S | 1 |
| Weiyuan, M | 1 |
5 other studies available for metformin and Keloid
| Article | Year |
|---|---|
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; | 2022 |
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; | 2022 |
Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids.
Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; | 2021 |
Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway.
Topics: Adult; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Down-Regulation; Drug Evaluation, Preclinica | 2019 |
[The effect of Metformin on the proliferation and collagen synthesis of human keloids fibroblasts].
Topics: Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Forkhead Box Protein O1 | 2015 |