isotretinoin and Keloid

Topics: Acne Vulgaris; Administration, Oral; Dermatologic Agents; Humans; Isotretinoin; Keloid; Treatment Outcome

Acne vulgaris is a chronic inflammatory disease characterized by non-inflammatory and inflammatory lesions that can cause scarring. Oral isotretinoin is the current recommended treatment for moderate and severe cases; however, there are reports of possible influences on the healing process of the skin, leading to an increase in the risk for hypertrophic scars and keloids. This hypothesis, although unproven, represents a contraindication to the treatment of acne scars during the 6-12 months after the cessation of isotretinoin.. The aim of this study was to investigate the prevalences of hypertrophic scars and keloids in acne patients treated with oral isotretinoin.. Three data collection strategies were used: (i) clinical examination of patients with acne vulgaris, exposed or unexposed to oral isotretinoin, focusing on the occurrence of hypertrophic scars and/or keloids; (ii) telephone interviews of patients using oral isotretinoin to treat acne vulgaris on the occurrence or worsening of keloids; and (iii) clinical examination of patients with previous use of oral isotretinoin followed at a specific keloid treatment clinic.. The resulting data showed no differences in wound healing.. These findings may indicate that the occurrence of hypertrophic scars or keloids in patients using oral isotretinoin is an undesirable event arising from an individual response and may be related to inflammatory acne evolution.

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Adult; Case-Control Studies; Cicatrix, Hypertrophic; Cross-Sectional Studies; Dermatologic Agents; Disease Progression; Female; Humans; Isotretinoin; Keloid; Male; Prevalence; Retrospective Studies; Wound Healing; Wounds and Injuries; Young Adult

Isotretinoin-induced keloid formation has occasionally been reported in patients who have undergone dermabrasion or laser treatment. This report describes a man with Behçet's disease (BD) who was prescribed isotretinoin for nodulocystic acne. After approximately 8 weeks of this treatment, the patient developed extensive keloids. There are no previous reports of possible isotretinoin-induced keloid formation in the setting of BD. This article discusses possible connections between BD, keloid formation and isotretinoin, which may be manifested in this case.

Topics: Acne Vulgaris; Adult; Behcet Syndrome; Drug Eruptions; Humans; Isotretinoin; Keloid; Keratolytic Agents; Male

Topics: Acne Vulgaris; Adolescent; Humans; Isotretinoin; Keloid; Keratolytic Agents; Male

Topics: Asian People; Black People; Dermatologic Agents; Gonadal Steroid Hormones; Humans; Isotretinoin; Keloid; Sebaceous Glands; Sebum

Topics: Adolescent; Female; Humans; Isotretinoin; Keloid; Keratolytic Agents; Laser Therapy; Lasers

In this study, we evaluated the effects of isotretinoin and triamcinolone acetonide on the growth of keloid and embryonal human skin fibroblasts in vitro. Culture bottles were plated with 2 x 10(5) cells and after 3 days of growth in Eagle's minimum essential medium, the medium was changed to one containing the drug being evaluated. Five groups were established: (1) regular medium as the control; (2) the medium containing 0.1% ethyl alcohol (the vehicle in which isotretinoin is dissolved); (3) the medium containing isotretinoin; (4) the medium containing triamcinolone acetonide; (5) the medium containing both drugs. Our study demonstrated that isotretinoin and triamcinolone acetonide each significantly inhibited the growth of the cells, and the effect of the combination was greater than that of either drug used alone.

Topics: Cell Count; Cell Division; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Isotretinoin; Keloid; Skin; Triamcinolone Acetonide

We report the observation of delayed wound healing and keloid formation in three patients, following dermabrasion or Argon laser treatment administered while they were receiving isotretinoin for acne or rosacea.

Topics: Acne Vulgaris; Adult; Aged; Dermabrasion; Female; Humans; Isomerism; Isotretinoin; Keloid; Laser Therapy; Male; Rosacea; Tretinoin; Wound Healing

Six patients underwent dermabrasion while on or having recently completed isotretinoin (Accutane) therapy. All patients developed keloids in atypical locations; the keloids eventually responded to topical or intralesional steroid therapy. Retinoids have a modulatory effect on connective tissue metabolism, including suppression of collagenase, which may enhance keloid formation. Dermabrasion should be delayed in those patients taking or recently on isotretinoin therapy.

Topics: Acne Vulgaris; Adult; Dermabrasion; Female; Humans; Isotretinoin; Keloid; Male; Microbial Collagenase; Middle Aged; Tretinoin