thalidomide has been researched along with Keloid in 1 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis." | 5.39 | Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. ( Chen, YL; Chien, HF; Hung, LY; Lee, CW; Liang, CJ; Pu, CM; Tsai, JS; Wang, SH; Yen, FL; Yen, YH, 2013) |
| "Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis." | 1.39 | Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. ( Chen, YL; Chien, HF; Hung, LY; Lee, CW; Liang, CJ; Pu, CM; Tsai, JS; Wang, SH; Yen, FL; Yen, YH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, CJ | 1 |
| Yen, YH | 1 |
| Hung, LY | 1 |
| Wang, SH | 1 |
| Pu, CM | 1 |
| Chien, HF | 1 |
| Tsai, JS | 1 |
| Lee, CW | 1 |
| Yen, FL | 1 |
| Chen, YL | 1 |
1 other study available for thalidomide and Keloid
| Article | Year |
|---|---|
Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway.
Topics: Adult; Animals; Base Sequence; Electrophoretic Mobility Shift Assay; Female; Fibroblasts; Fibronecti | 2013 |