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thalidomide and Keloid

thalidomide has been researched along with Keloid in 1 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.

Research Excerpts

ExcerptRelevanceReference
"Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis."5.39Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. ( Chen, YL; Chien, HF; Hung, LY; Lee, CW; Liang, CJ; Pu, CM; Tsai, JS; Wang, SH; Yen, FL; Yen, YH, 2013)
"Keloids are characterized by the vigorously continuous production of extracellular matrix protein and aberrant cytokine activity in the dermis."1.39Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. ( Chen, YL; Chien, HF; Hung, LY; Lee, CW; Liang, CJ; Pu, CM; Tsai, JS; Wang, SH; Yen, FL; Yen, YH, 2013)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liang, CJ1
Yen, YH1
Hung, LY1
Wang, SH1
Pu, CM1
Chien, HF1
Tsai, JS1
Lee, CW1
Yen, FL1
Chen, YL1

Other Studies

1 other study available for thalidomide and Keloid

ArticleYear
Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway.
    Biochemical pharmacology, 2013, Jun-01, Volume: 85, Issue:11

    Topics: Adult; Animals; Base Sequence; Electrophoretic Mobility Shift Assay; Female; Fibroblasts; Fibronecti

2013