hydroxyproline has been researched along with Keloid in 14 studies
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.
Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the inhibitory effects of tranilast, an anti-allergic drug, on the human keloid tissues implanted into the dorsal skin of athymic nude mice and on the growth of keloid fibroblast in vitro." | 7.68 | [Effect of tranilast, an anti-allergic drug, on the human keloid tissues]. ( Arai, N; Hamano, S; Ichikawa, K; Kikuchi, S; Momose, Y; Shibata, N; Sugimoto, C; Suzawa, H; Tazawa, S; Tsuchiya, O, 1992) |
| "We compared the expression and activity of chymase in keloids and normal skin tissues using Western blotting and radioimmunoassay, and studied the expression of TGF-β1, interleukin-1β, collagen I, hydroxyproline, and angiotensin II in KFs after chymase and inhibitors' treatment." | 3.81 | Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids. ( Cen, Y; Chen, J; Wang, R; Zhang, Z, 2015) |
| "The content of hydroxyproline was determined and the expression of connective tissue growth factor gene was detected by the reverse transcription-polymerase chain reaction and image analysis technique in 5 normal skins, 15 hypertrophic scars and 7 keloid tissues." | 3.72 | [Expression of connective tissue growth factor gene in the hypertrophic scar and keloid tissue]. ( Ji, SX; Li, SR; Liu, JY, 2003) |
| "We studied the inhibitory effects of tranilast, an anti-allergic drug, on the human keloid tissues implanted into the dorsal skin of athymic nude mice and on the growth of keloid fibroblast in vitro." | 3.68 | [Effect of tranilast, an anti-allergic drug, on the human keloid tissues]. ( Arai, N; Hamano, S; Ichikawa, K; Kikuchi, S; Momose, Y; Shibata, N; Sugimoto, C; Suzawa, H; Tazawa, S; Tsuchiya, O, 1992) |
| "A comparison of the rates of synthesis of collagen in normal skin, normal and hypertrophic scars, and keloids has been made by measuring the rate of incorporation of [14-C]-proline into peptide-bound [14-C]-hydroxyproline by tissue minces in vitro." | 3.65 | Collagen biosynthesis in normal human skin, normal and hypertrophic scar and keloid. ( Craig, RD, 1975) |
| "Keloids are a dermal fibrotic disease whose etiology remains totally unknown and for which there is no successful treatment." | 1.51 | Tension enhances cell proliferation and collagen synthesis by upregulating expressions of integrin αvβ3 in human keloid-derived mesenchymal stem cells. ( Cao, T; Liu, T; Lv, Y; Ma, B; Pang, H; Song, H; Wang, W; Zhai, D; Zhang, H; Zhang, Y; Zhou, Z, 2019) |
| "Keloid is a tissue with an excessive accumulation of collagen." | 1.30 | Altered posttranslational modifications of collagen in keloid. ( Katz, EP; Marshall, MK; Tanzawa, H; Uzawa, K; Yamauchi, M; Yeowell, HN, 1998) |
| "Keloids are benign cutaneous tumours characterized by excess deposition of collagen, specifically type I collagen." | 1.28 | Endothelial cell growth factor and heparin regulate collagen gene expression in keloid fibroblasts. ( Peltonen, J; Tan, EM, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, H | 1 |
| Liu, T | 1 |
| Wang, W | 1 |
| Pang, H | 1 |
| Zhou, Z | 1 |
| Lv, Y | 1 |
| Cao, T | 1 |
| Zhai, D | 1 |
| Ma, B | 1 |
| Zhang, H | 1 |
| Zhang, Y | 1 |
| Wang, R | 1 |
| Chen, J | 1 |
| Zhang, Z | 1 |
| Cen, Y | 1 |
| AMANTE, L | 1 |
| BAIRATI, A | 1 |
| PERNIS, B | 1 |
| GREEN, H | 1 |
| GOLDBERG, B | 1 |
| Liu, JY | 1 |
| Li, SR | 1 |
| Ji, SX | 1 |
| Tan, EM | 2 |
| Rouda, S | 1 |
| Greenbaum, SS | 1 |
| Moore, JH | 1 |
| Fox, JW | 1 |
| Sollberg, S | 1 |
| Uzawa, K | 1 |
| Marshall, MK | 1 |
| Katz, EP | 1 |
| Tanzawa, H | 1 |
| Yeowell, HN | 1 |
| Yamauchi, M | 1 |
| Craig, RD | 3 |
| Schofield, JD | 1 |
| Jackson, DS | 1 |
| Suzawa, H | 1 |
| Kikuchi, S | 1 |
| Ichikawa, K | 1 |
| Arai, N | 1 |
| Tazawa, S | 1 |
| Tsuchiya, O | 1 |
| Momose, Y | 1 |
| Shibata, N | 1 |
| Sugimoto, C | 1 |
| Hamano, S | 1 |
| Peltonen, J | 1 |
| Milsom, JP | 1 |
| Bazin, S | 1 |
| Nicoletis, C | 1 |
| Delbet, JP | 1 |
| Delaunay, A | 1 |
| Sandberg, L | 1 |
| Sandberg, N | 1 |
14 other studies available for hydroxyproline and Keloid
| Article | Year |
|---|---|
Tension enhances cell proliferation and collagen synthesis by upregulating expressions of integrin αvβ3 in human keloid-derived mesenchymal stem cells.
Topics: Adolescent; Adult; Blotting, Western; Cell Proliferation; Collagen; Female; Flow Cytometry; Gene Exp | 2019 |
Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids.
Topics: Adolescent; Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting E | 2015 |
[RESEARCH ON THE NATURE AND ULTRASTRUCTURE OF KELOIDS. III. CHEMICAL ANALYSIS].
Topics: Chemical Phenomena; Chemistry; Chromatography; Collagen; Hydroxyproline; Keloid; Proteins; Research | 1963 |
COLLAGEN SYNTHESIS BY HUMAN FIBROBLAST STRAINS.
Topics: Child; Collagen; Fetus; Fibroblasts; Humans; Hydroxyproline; Keloid; Lung; Proline; Proteins; Resear | 1964 |
[Expression of connective tissue growth factor gene in the hypertrophic scar and keloid tissue].
Topics: Adolescent; Adult; Cicatrix, Hypertrophic; Connective Tissue Growth Factor; Female; Gene Expression; | 2003 |
Acidic and basic fibroblast growth factors down-regulate collagen gene expression in keloid fibroblasts.
Topics: Collagen; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; | 1993 |
Altered posttranslational modifications of collagen in keloid.
Topics: Adult; Amino Acids; Collagen; Cross-Linking Reagents; Desmosine; Dipeptides; Histidine; Humans; Hydr | 1998 |
Collagen biosynthesis in normal human skin, normal and hypertrophic scar and keloid.
Topics: Carbon Radioisotopes; Cicatrix; Collagen; Humans; Hydroxyproline; Hypertrophy; In Vitro Techniques; | 1975 |
Collagen biosynthesis in normal and hypertrophic scars and keloid as a function of the duration of the scar.
Topics: Cicatrix; Collagen; Humans; Hydroxyproline; Hypertrophy; In Vitro Techniques; Keloid; Kinetics; Prol | 1975 |
[Effect of tranilast, an anti-allergic drug, on the human keloid tissues].
Topics: Animals; Cell Division; Cells, Cultured; Collagen; Disease Models, Animal; Extracellular Matrix; Fib | 1992 |
Endothelial cell growth factor and heparin regulate collagen gene expression in keloid fibroblasts.
Topics: Adult; Blotting, Northern; Cells, Cultured; Collagen; DNA Probes; Endothelial Growth Factors; Fibrob | 1991 |
Collagen degradation in cultured keloid and hypertrophic scar tissue.
Topics: Adolescent; Adult; Aged; Carbon Radioisotopes; Child; Child, Preschool; Cicatrix; Collagen; Culture | 1973 |
[Degree of collagen maturation in normal and keloid cicatrix].
Topics: Aging; Cicatrix; Collagen; Humans; Hydroxyproline; Keloid; Skin | 1970 |
Endocrine stimulation of healing. A study of collagen formation and wound tensile strength in pregnant rats.
Topics: Animals; Chorionic Gonadotropin; Collagen; Endocrine Glands; Female; Granulation Tissue; Hemangioma; | 1966 |