Page last updated: 2024-11-07

delta-hydroxylysylnorleucine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Delta-hydroxylysylnorleucine (DHLNL) is a synthetic analog of hydroxylysine, a non-proteinogenic amino acid found in collagen. DHLNL is incorporated into collagen during biosynthesis in place of hydroxylysine, resulting in the formation of a modified collagen molecule. This modification leads to the disruption of collagen fibril assembly, resulting in weakened collagen fibers. DHLNL has been studied as a potential therapeutic agent for treating fibrotic diseases, such as liver fibrosis and pulmonary fibrosis, by inhibiting the formation of excessive collagen. The compound has also been investigated as a tool to study the role of collagen in various biological processes, including wound healing and angiogenesis.'
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delta-hydroxylysylnorleucine: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122155
MeSH IDM0056949

Synonyms (7)

Synonym
hlnl
21895-67-0
5-hydroxylysylnorleucine
n(6)-(5-amino-5-carboxypentyl)-5-hydroxylysine
delta-hydroxy-lys-nle
delta-hydroxylysylnorleucine
(2s,5s)-2-amino-6-[(5-amino-5-carboxypentyl)amino]-5-hydroxyhexanoic acid

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" In conclusion, AG at moderate dosage does not seem to influence the formation of lysyl oxidase dependent reducible cross-links of collagen."( The influence of aminoguanidine on borohydride reducible collagen cross-links and wound strength.
Andreassen, TT; Jørgensen, PH; Oxlund, H; Seyer-Hansen, M, 1991
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (48)

TimeframeStudies, This Drug (%)All Drugs %
pre-199020 (41.67)18.7374
1990's21 (43.75)18.2507
2000's4 (8.33)29.6817
2010's3 (6.25)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.22 (24.57)
Research Supply Index3.97 (2.92)
Research Growth Index4.19 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.96%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (1.96%)4.05%
Observational0 (0.00%)0.25%
Other49 (96.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]