aminolevulinic acid has been researched along with Keloid in 10 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case report of massive mandibular keloid with severe infection induced by acne achieved resolution of skin lesions after combined treatment with surgery and high concentration single-dose 5-aminolevulinic acid photodynamic therapy (5-ALA PDT)." | 4.02 | A massive mandibular keloid with severe infection: What is your treatment? ( Chen, XD; Gao, LM; Wu, XY; Zhao, LT, 2021) |
| "To investigate the effect of 8-aminolevulinic acid (ALA) photodynamic therapy (PDT) on the cell proliferation, apoptosis and collagen secretion in keloid fibroblasts and to provide the theoretical base for ALA-PDT treatment of keloids." | 3.81 | [Effect of photodynamic therapy on the cell proliferation and collagen secretion of keloid fibroblasts]. ( Fan, Y; Jiao, J, 2015) |
| "Fibroblasts from keloid patients were cultured to the third generation in vitro and incubated in 0, 1, 3, 6, 9 mmol/L of δ-aminolevulinic acid for 3 h in the darkness." | 3.81 | [Effect of photodynamic therapy on the cell proliferation and collagen secretion of keloid fibroblasts]. ( Fan, Y; Jiao, J, 2015) |
| "In concentration within the range of 1-9 mmol/L, ALA could inhibit the proliferation of fibroblasts significantly, promote fibroblasts apoptosis and reduce the content of hydroxyproline in a dose-dependent manner, indicating that 8-aminolevulinic acid photodynamic therapy may be a potential treatment for keloid." | 3.81 | [Effect of photodynamic therapy on the cell proliferation and collagen secretion of keloid fibroblasts]. ( Fan, Y; Jiao, J, 2015) |
| "In this study, we evaluated the in vitro cytotoxic effect of PDT at 5J/cm(2) and 10J/cm(2) of red light (633 ± 3nm) using 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) with and without DW, on keloid fibroblasts compared to normal skin fibroblasts." | 3.77 | Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy. ( Allan, D; Allan, E; Bayat, A; Colthurst, J; Sebastian, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 2 |
| Liu, L | 1 |
| Li, X | 1 |
| Shen, X | 1 |
| Yang, G | 1 |
| Deng, Y | 1 |
| Hu, Z | 1 |
| Lu, Y | 1 |
| Bu, W | 1 |
| Fang, F | 1 |
| Zhang, M | 1 |
| Chen, J | 1 |
| Zhao, LT | 1 |
| Gao, LM | 1 |
| Chen, XD | 1 |
| Wu, XY | 1 |
| Jiao, J | 1 |
| Fan, Y | 1 |
| Zhong, JB | 1 |
| Cen, Y | 1 |
| Liu, Q | 1 |
| Nie, Z | 1 |
| Bayat, A | 4 |
| Behzad, F | 1 |
| Rhodes, LE | 1 |
| Sebastian, A | 2 |
| Allan, E | 2 |
| Allan, D | 2 |
| Colthurst, J | 1 |
| Mendoza, J | 1 |
| Mandal, P | 1 |
| Alonso-Rasgado, T | 1 |
| Ud-Din, S | 1 |
| Thomas, G | 1 |
| Morris, J | 1 |
| Liu, T | 1 |
| Ma, X | 1 |
| Ouyang, T | 1 |
| Chen, H | 1 |
| Xiao, Y | 1 |
| Huang, Y | 1 |
| Liu, J | 1 |
| Xu, M | 1 |
10 other studies available for aminolevulinic acid and Keloid
| Article | Year |
|---|---|
5-ALA-PDT induced ferroptosis in keloid fibroblasts via ROS, accompanied by downregulation of xCT, GPX4.
Topics: Aminolevulinic Acid; Down-Regulation; Ferroptosis; Fibroblasts; Humans; Keloid; Photochemotherapy; P | 2023 |
Combination of 5-ALA photodynamic therapy, surgery and superficial X-ray for the treatment of keloid.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Humans; Keloid; Male; Middle Aged; Photochemotherapy; X-Ra | 2020 |
A massive mandibular keloid with severe infection: What is your treatment?
Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Keloid; Photochemotherapy; Photosensitizing Agents; Trea | 2021 |
[Effect of photodynamic therapy on the cell proliferation and collagen secretion of keloid fibroblasts].
Topics: Aminolevulinic Acid; Apoptosis; Cell Culture Techniques; Cell Proliferation; Collagen; Fibroblasts; | 2015 |
[Study on the inhibitory effect of ALA-PDT on the proliferation of fibroblasts from keloid].
Topics: Aminolevulinic Acid; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Keloid; Lasers; Photo | 2010 |
Positive response of a recurrent keloid scar to topical methyl aminolevulinate-photodynamic therapy.
Topics: Adult; Aminolevulinic Acid; Female; Fibroblasts; Humans; Keloid; Photochemotherapy; Photosensitizing | 2010 |
Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: first report of a potential combination therapy.
Topics: Adult; Aged; Aminolevulinic Acid; Apoptosis; Blotting, Western; Case-Control Studies; Caspase 3; Cel | 2011 |
Differential cytotoxic response in keloid fibroblasts exposed to photodynamic therapy is dependent on photosensitiser precursor, fluence and location of fibroblasts within the lesion.
Topics: Adult; Aminolevulinic Acid; Apoptosis; Cell Differentiation; Cells, Cultured; Cellular Senescence; F | 2012 |
Photodynamic therapy: an innovative approach to the treatment of keloid disease evaluated using subjective and objective non-invasive tools.
Topics: Aminolevulinic Acid; Collagen; Female; Hemoglobins; Humans; Keloid; Male; Melanins; Pain Measurement | 2013 |
Efficacy of 5-aminolevulinic acid-based photodynamic therapy against keloid compromised by downregulation of SIRT1-SIRT3-SOD2-mROS dependent autophagy pathway.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Fibroblasts; Humans; Keloid; Levulinic Acids; Light; Oxid | 2019 |