| Assay ID | Title | Year | Journal | Article |
|---|
| AID101619 | In vitro inhibitory activity against mammary carcinoma MDA 468 cell lines | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID144773 | In vitro antitumor activity against carcinoma cell lines by 2-day assay | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID1656538 | Inhibition of recombinant human MMP2 catalytic domain (Tyr110 to Asp452 residues) expressed in yeast cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as fluorogenic substrate preincubated for 15 mi | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. |
| AID19837 | Apparent lipophilicity was determined | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. |
| AID104086 | In vitro inhibitory activity against mammary carcinoma MCF-7 cell lines | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID497352 | Cell cycle arrest in human BCC cells assessed as accumulation at sub G1 phase at 4 uM incubated for 4 hrs followed by 1 J/cm'2 UV irradiation measured after 24 hrs by annexin V/propidium iodide-based flow cytometry | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
| Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. |
| AID208683 | In vitro cytotoxicity against T47D human breast cancer cell line with ER negative | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID104082 | In vitro cytotoxicity against MCF-7 human mammary carcinoma cells | 1999 | Journal of medicinal chemistry, Oct-07, Volume: 42, Issue:20
| Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles. |
| AID1424530 | Phototoxicity in human keloid fibroblasts assessed as cell viability at 2 to 8 umol/L pre-incubated for 4 hrs before 0.5 J.cm2 UVA irradiation by MTT assay | 2017 | European journal of medicinal chemistry, Dec-15, Volume: 142 | Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents. |
| AID208529 | In vitro cytotoxicity against T24 human prostate cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID10023 | In vitro cytotoxicity against A2780 human ovarian cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID216589 | In vitro cytotoxicity against WiDr human colon cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID104117 | In vitro antitumor activity against MDA-468 carcinoma cell line. | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID202675 | In vitro cytotoxicity against SKBR 3 human breast cancer cell line with ER negative | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID220398 | In vitro cytotoxicity against ZR 75 human breast cancer cell line with ER positive | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID92292 | In vitro concentration to reduce colony formation of human tumor xenografts to 30% of the control | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID104116 | Inhibitory activity of compound against breast cancer cell line MDA 468, following 72 hr treatment | 2003 | Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3
| Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. |
| AID102101 | In vitro antitumor activity against MCF-7 carcinoma cell line. | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID1656539 | Inhibition of recombinant human MMP13 catalytic domain (Tyr104 to Asn274 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as fluorogenic substrate preincubat | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. |
| AID92290 | Clonal growth inhibition by the compound at at a concentration of 10(ug/mL) in human tumor xenografts in vitro. active, T/C < 30%; activity value is 5/22 | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID57884 | In vitro cytotoxicity against DU-145 human prostate cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID83610 | In vitro cytotoxicity against HT-29 human colon cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID9806 | In vitro cytotoxicity against A204 human rhabdomyosarcoma cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID92285 | Clonal growth inhibition by the compound at at a concentration of 1(ug/mL) in human tumor xenografts in vitro. active, T/C < 30%; activity value is 0/22 | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID104075 | In vitro cytotoxicity against MCF-7 human breast cancer cell line with ER positive | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID1656541 | Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as fluorogenic substrate preincubate | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. |
| AID92282 | Clonal growth inhibition by the compound at at a concentration of 0.1(ug/mL) in human tumor xenografts in vitro. active, T/C < 30%; activity value is 0/22 | 1999 | Journal of medicinal chemistry, Feb-11, Volume: 42, Issue:3
| Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. |
| AID101575 | Inhibitory activity of compound against breast cancer cell line MCF-7, following 72 hr treatment | 2003 | Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3
| Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues. |
| AID38663 | Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. |
| AID104130 | In vitro cytotoxicity against MDA 231 human breast cancer cell line with EGFR positive erbB3 positive | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID1656540 | Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli cells using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2/TQ3-GABA-Pro-Cha-Abu-Smc-His-Ala-Dab(6'-TAMRA)-Ala-Lys-NH2 as fluorogenic substrate preincubated | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. |
| AID101618 | In vitro cytotoxicity against MDA 468 human breast cancer cell line with ER negative EGFR positive | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID93476 | In vitro cytotoxicity against IGROVIg-37 human melanoma cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID103089 | In vitro cytotoxicity against MCF-7/Adr human breast cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID156167 | In vitro cytotoxicity against PC-3 human prostate cancer cell line | 1996 | Journal of medicinal chemistry, Aug-16, Volume: 39, Issue:17
| Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |