fluorouracil has been researched along with Keloid in 85 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to determine whether and how Strontium-90 brachytherapy as an adjuvant radiation could affect keloid recurrence after intralesional triamcinolone and 5-fluorouracil injections." | 9.41 | Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial. ( Deng, K; Liu, X; Liu, Y; Ogawa, R; Xiao, H; Xu, X, 2021) |
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 9.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| "The objective of this study was to compare the efficacy of post-excision intralesional 5-fluorouracil/triamcinolone acetonide (5-FU/TAC) and post-excision radiotherapy in the treatment of ear keloids." | 9.27 | The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial. ( Amin, M; Farooq, UK; Khalid, FA; Khan, KU; Mehrose, Y; Rabbani, J; Saleem, M; Tarar, MN, 2018) |
| "To compare the use of intralesional triamcinolone acetonide and its combination with 5 flourouracil in the treatment of keloid and hypertrophic scars in terms of reduction in initial height of the scar." | 9.19 | Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. ( Bashir, MM; Khan, FA; Khan, MA, 2014) |
| "To compare 5-fluorouracil (5-FU) tattooing and intralesional steroid for treatment of keloids." | 9.16 | Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. ( Sadeghinia, A; Sadeghinia, S, 2012) |
| "To investigate whether intralesional injection of low-dose 5-fluorouracil (5-Fu) and corticosteroid can increase effective rate and decrease recurrence rate of surgically removed auricular keloid." | 9.14 | [Clinical study of auricular keloid treatment with both surgical excision and intralesional injection of low-dose 5-fluorouracil and corticosteroids]. ( Gao, Z; Liu, W; Song, N; Wu, XL, 2009) |
| "Triamcinolone acetonide (TAC) is widely used for hypertrophic scars and keloids; however, TAC has variable efficacy and safety in different individuals." | 9.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result." | 9.12 | [Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil]. ( Cao, YL; Liu, W; Wu, XL, 2006) |
| "To evaluate the efficacy and side effects of 5-fluorouracil (5-FU) as a therapeutic agent in the treatment of keloids of any duration or size." | 9.11 | Intralesional 5-fluorouracil as a treatment modality of keloids. ( Nanda, S; Reddy, BS, 2004) |
| "To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL)." | 9.10 | Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. ( Fitzpatrick, RE; Manuskiatti, W, 2002) |
| "The possibility of altering the pathophysiology of keloid scars was investigated in 11 patients, using a single application of 5-fluorouracil solution for 5 minutes after extralesional excision was performed." | 9.09 | The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. ( Chapman, P; Kakar, S; Khan, U; McGrouther, AD; Talas, G; Uppal, RS, 2001) |
| " Predictor variables were 5-fluorouracil (5-FU) or triamcinolone adjuvant therapy, and the outcome variable was keloid recurrence rate." | 8.93 | Could 5-Fluorouracil or Triamcinolone Be an Effective Treatment Option for Keloid After Surgical Excision? A Meta-Analysis. ( Kim, JS; Shin, JY, 2016) |
| "Intralesional 5-fluorouracil (5-FU) in combination with triamcinolone acetonide (TAC) has been recommended as a promising alternative for keloids not responding to silicone-based products, cryotherapy or intralesional corticosteroids alone." | 7.96 | Treatment of keloids using 5-fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non-invasive objective measures. ( Gauglitz, GG; Guertler, A; Poetschke, J; Reinholz, M; Schwaiger, H, 2020) |
| "To evaluate the effectiveness of combined ablative fractional CO2 laser and topically applied 5-fluorouracil (5-FU) or verapamil hydrochloride in the treatment of hypertrophic scars (HTSs) and keloids and to examine their possible effects on TGF-β1 expression." | 7.91 | The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. ( Abd El Azez, TA; Abdel Rahman, SH; Hussein, MS; Sabry, HH; Sanad, RR, 2019) |
| "Preliminary clinical trials suggest a superior effect when steroids and 5-fluorouracil are injected together for the intralesional therapy of keloids." | 7.79 | A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro. ( Burd, A; Cai, YJ; Huang, L; Leung, BC; Lung, I, 2013) |
| "Intralesional injection of low-dose 5-fluorouracil (5-FU) has recently been used as an experimental modality for treating keloid scarring and has shown promising efficacy in improving scar appearance and preventing recurrence of the keloid." | 7.76 | Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts. ( Burd, A; Cai, YJ; Huang, L; Leung, CS; Lung, I; Wong, YP, 2010) |
| " This review assesses recurrence and the reporting of recurrence in pathologic scar after treatment with intralesional triamcinolone (TAC) in combination with another intralesional agent." | 7.01 | Recurrence rates in the treatment of keloids and hypertrophic scars with intralesional triamcinolone combined with other intralesional agents. ( Chandy, RJ; Feldman, SR; Khan, D; Rimmer, SN, 2023) |
| "Keloids are a major complication related to surgical wound healing and very challenging condition to treat." | 6.94 | Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial. ( Hietanen, KE; Huhtala, H; Järvinen, TAH; Kaartinen, IS; Tolonen, TT, 2020) |
| "Keloids have high recurrence rates." | 6.90 | Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial. ( Hietanen, KE; Huhtala, H; Järvinen, TA; Kaartinen, IS; Kuokkanen, HO; Tolonen, TT, 2019) |
| "Keloids are aesthetically disfiguring and severely disabling." | 6.76 | Effects of combined intralesional 5-Fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study. ( Ghafarian Shirazi, HR; Hatamipour, E; Hatamipour, M; Mehrabi, S, 2011) |
| "Keloids and hypertrophic scars are benign growths of dermal collagen that can cause physical and psychological (cosmetic) problems for patients." | 6.74 | Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. ( Asilian, A; Darougheh, A; Shariati, F, 2009) |
| "Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems." | 6.72 | New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. ( Asilian, A; Darougheh, A; Shariati, F, 2006) |
| " Cryosurgery and intralesional corticosteroids have been considered as the mainstream of therapy; however, the long-term use of corticosteroids has been found to be associated with serious side effects." | 6.70 | Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. ( Gupta, S; Kalra, A, 2002) |
| " We aimed to compare the efficacy and safety of TAC alone and in combination with 5-FU for the treatment of hypertrophic scars and keloids." | 6.55 | Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( Fan, B; Feng, S; Lin, W; Ren, Y; Wei, Z; Zhou, X, 2017) |
| "Keloid is a highly aggressive fibrotic disease resulting from excessive extracellular matrix deposition after dermal injury." | 5.91 | Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil. ( Hao, Y; Kuang, X; Liang, Z; Liu, H; Shan, M; Wang, Y; Xia, Y, 2023) |
| "Hyperpigmentation was the most irritating side effect of 5-FU that occurred." | 5.72 | Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022) |
| "We used microneedles to treat keloid because this method has the feasibility of self-administration without pain." | 5.62 | Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment. ( Kim, YC; Park, J, 2021) |
| "Keloids are benign fibroproliferative skin tumors that can cause disfigurement and disability." | 5.51 | Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence. ( Chong, T; Costa, C; Karimpour-Fard, A; LaRanger, R; Mathes, D; Wright, WE, 2019) |
| "We aimed to determine whether and how Strontium-90 brachytherapy as an adjuvant radiation could affect keloid recurrence after intralesional triamcinolone and 5-fluorouracil injections." | 5.41 | Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial. ( Deng, K; Liu, X; Liu, Y; Ogawa, R; Xiao, H; Xu, X, 2021) |
| "The objective was to establish the safety and efficacy of intralesional 5-fluorouracil (5-FU) for the treatment of keloids and hypertrophic scars." | 5.30 | Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. ( Ahmad, S; Khalid, FA; Mehrose, MY; Mujahid, AM; Rehman, SU; Saleem, M; Tarar, MN; Yousaf, MA, 2019) |
| "The objective of this study was to compare the efficacy of post-excision intralesional 5-fluorouracil/triamcinolone acetonide (5-FU/TAC) and post-excision radiotherapy in the treatment of ear keloids." | 5.27 | The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial. ( Amin, M; Farooq, UK; Khalid, FA; Khan, KU; Mehrose, Y; Rabbani, J; Saleem, M; Tarar, MN, 2018) |
| "To compare the use of intralesional triamcinolone acetonide and its combination with 5 flourouracil in the treatment of keloid and hypertrophic scars in terms of reduction in initial height of the scar." | 5.19 | Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. ( Bashir, MM; Khan, FA; Khan, MA, 2014) |
| "To compare 5-fluorouracil (5-FU) tattooing and intralesional steroid for treatment of keloids." | 5.16 | Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. ( Sadeghinia, A; Sadeghinia, S, 2012) |
| "To investigate whether intralesional injection of low-dose 5-fluorouracil (5-Fu) and corticosteroid can increase effective rate and decrease recurrence rate of surgically removed auricular keloid." | 5.14 | [Clinical study of auricular keloid treatment with both surgical excision and intralesional injection of low-dose 5-fluorouracil and corticosteroids]. ( Gao, Z; Liu, W; Song, N; Wu, XL, 2009) |
| "Triamcinolone acetonide (TAC) is widely used for hypertrophic scars and keloids; however, TAC has variable efficacy and safety in different individuals." | 5.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result." | 5.12 | [Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil]. ( Cao, YL; Liu, W; Wu, XL, 2006) |
| "To evaluate the efficacy and side effects of 5-fluorouracil (5-FU) as a therapeutic agent in the treatment of keloids of any duration or size." | 5.11 | Intralesional 5-fluorouracil as a treatment modality of keloids. ( Nanda, S; Reddy, BS, 2004) |
| "To compare the clinical response of keloidal and hypertrophic scars after treatment with intralesional corticosteroid alone or combined with 5-fluorouracil (5-FU), 5-FU alone, and the 585-nm flashlamp-pumped pulsed-dye laser (PDL)." | 5.10 | Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. ( Fitzpatrick, RE; Manuskiatti, W, 2002) |
| "The possibility of altering the pathophysiology of keloid scars was investigated in 11 patients, using a single application of 5-fluorouracil solution for 5 minutes after extralesional excision was performed." | 5.09 | The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. ( Chapman, P; Kakar, S; Khan, U; McGrouther, AD; Talas, G; Uppal, RS, 2001) |
| " Predictor variables were 5-fluorouracil (5-FU) or triamcinolone adjuvant therapy, and the outcome variable was keloid recurrence rate." | 4.93 | Could 5-Fluorouracil or Triamcinolone Be an Effective Treatment Option for Keloid After Surgical Excision? A Meta-Analysis. ( Kim, JS; Shin, JY, 2016) |
| "Intralesional triamcinolone is a gold standard in treating the keloids in comparison with its effectiveness versus intralesional 5-fluorouracil intralesional verapamil and intralesional platelet-rich plasma." | 4.12 | Assessment of various intralesional injections in keloid: comparative analysis. ( Albalat, W; Khattab, F; Nabil, S, 2022) |
| " Combination therapy of intralesional 5-fluorouracil and triamcinolone offers efficacious treatment for keloids with a reduced adverse effect of the drug monotherapy." | 3.96 | Potentials for implementing pressure-controlled jet injection in management of keloids with intralesional 5FU and corticosteroids. ( Artzi, O; Levenberg, A; Vinshtok, Y, 2020) |
| "Intralesional 5-fluorouracil (5-FU) in combination with triamcinolone acetonide (TAC) has been recommended as a promising alternative for keloids not responding to silicone-based products, cryotherapy or intralesional corticosteroids alone." | 3.96 | Treatment of keloids using 5-fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non-invasive objective measures. ( Gauglitz, GG; Guertler, A; Poetschke, J; Reinholz, M; Schwaiger, H, 2020) |
| "To evaluate the effectiveness of combined ablative fractional CO2 laser and topically applied 5-fluorouracil (5-FU) or verapamil hydrochloride in the treatment of hypertrophic scars (HTSs) and keloids and to examine their possible effects on TGF-β1 expression." | 3.91 | The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study. ( Abd El Azez, TA; Abdel Rahman, SH; Hussein, MS; Sabry, HH; Sanad, RR, 2019) |
| "Preliminary clinical trials suggest a superior effect when steroids and 5-fluorouracil are injected together for the intralesional therapy of keloids." | 3.79 | A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro. ( Burd, A; Cai, YJ; Huang, L; Leung, BC; Lung, I, 2013) |
| "Intralesional injection of low-dose 5-fluorouracil (5-FU) has recently been used as an experimental modality for treating keloid scarring and has shown promising efficacy in improving scar appearance and preventing recurrence of the keloid." | 3.76 | Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts. ( Burd, A; Cai, YJ; Huang, L; Leung, CS; Lung, I; Wong, YP, 2010) |
| "Intralesional treatments for keloid and hypertrophic scars may be the most reliable treatment option to improve pathologic scars, while laser treatment may have specific benefits for Fitzpatrick skin types I-III over types IV-VI." | 3.01 | Treatment of traumatic hypertrophic scars and keloids: a systematic review of randomized control trials. ( Alam, M; Anvery, N; Asadbeigi, SN; Christensen, RE; Dirr, MA; Hisham, FI; Ibrahim, SA; Jain-Poster, K; Kang, BY; Kim, K; Merkel, EA; Poon, E; Reynolds, KA; Worley, B, 2023) |
| " No serious adverse reactions and good tolerability were reported in the included studies." | 3.01 | Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review. ( Bekkers, VZ; Bik, L; Prens, EP; van Doorn, MBA; van Huijstee, JC; Wolkerstorfer, A, 2023) |
| " This review assesses recurrence and the reporting of recurrence in pathologic scar after treatment with intralesional triamcinolone (TAC) in combination with another intralesional agent." | 3.01 | Recurrence rates in the treatment of keloids and hypertrophic scars with intralesional triamcinolone combined with other intralesional agents. ( Chandy, RJ; Feldman, SR; Khan, D; Rimmer, SN, 2023) |
| "Keloids are pathologic scars that pose a significant functional and cosmetic burden." | 3.01 | Keloid treatments: an evidence-based systematic review of recent advances. ( Kundu, RV; Kwan, KR; Miller, CH; Pontes, D; Poondru, S; Walsh, LA; Wu, E, 2023) |
| "Keloids are a major complication related to surgical wound healing and very challenging condition to treat." | 2.94 | Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial. ( Hietanen, KE; Huhtala, H; Järvinen, TAH; Kaartinen, IS; Tolonen, TT, 2020) |
| "Keloids have high recurrence rates." | 2.90 | Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial. ( Hietanen, KE; Huhtala, H; Järvinen, TA; Kaartinen, IS; Kuokkanen, HO; Tolonen, TT, 2019) |
| "Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy." | 2.82 | Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022) |
| "Keloids are aesthetically disfiguring and severely disabling." | 2.76 | Effects of combined intralesional 5-Fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study. ( Ghafarian Shirazi, HR; Hatamipour, E; Hatamipour, M; Mehrabi, S, 2011) |
| "Keloids and hypertrophic scars are benign growths of dermal collagen that can cause physical and psychological (cosmetic) problems for patients." | 2.74 | Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. ( Asilian, A; Darougheh, A; Shariati, F, 2009) |
| "Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems." | 2.72 | New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. ( Asilian, A; Darougheh, A; Shariati, F, 2006) |
| " Cryosurgery and intralesional corticosteroids have been considered as the mainstream of therapy; however, the long-term use of corticosteroids has been found to be associated with serious side effects." | 2.70 | Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. ( Gupta, S; Kalra, A, 2002) |
| "Hypertrophic scars and keloids may complicate wound healing secondary to trauma or surgery." | 2.69 | Treatment of inflamed hypertrophic scars using intralesional 5-FU. ( Fitzpatrick, RE, 1999) |
| " We aimed to compare the efficacy and safety of TAC alone and in combination with 5-FU for the treatment of hypertrophic scars and keloids." | 2.55 | Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. ( Fan, B; Feng, S; Lin, W; Ren, Y; Wei, Z; Zhou, X, 2017) |
| "Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar." | 2.46 | The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review. ( Basdag, B; Magarakis, M; Manson, PN; Rosson, GD; Shridharani, SM; Singh, NK, 2010) |
| "Keloids are benign, but sometimes painful and/or pruritic, proliferative growths of dermal collagen, usually resulting from excessive tissue response to trauma." | 2.42 | Medical and surgical therapies for keloids. ( Kelly, AP, 2004) |
| "Auricular keloids are difficult to treat, and recurrent keloids are more aggressive and more likely to develop aural deformities." | 1.91 | Contour first-retrospective study of an algorithmic approach of auricular keloids. ( Dong, G; Hu, J; Jin, Q; Liu, Y; Qu, C; Wang, L; Wang, M; Wu, H, 2023) |
| "Keloid is a highly aggressive fibrotic disease resulting from excessive extracellular matrix deposition after dermal injury." | 1.91 | Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil. ( Hao, Y; Kuang, X; Liang, Z; Liu, H; Shan, M; Wang, Y; Xia, Y, 2023) |
| "Hyperpigmentation was the most irritating side effect of 5-FU that occurred." | 1.72 | Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022) |
| "We used microneedles to treat keloid because this method has the feasibility of self-administration without pain." | 1.62 | Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment. ( Kim, YC; Park, J, 2021) |
| "Keloids are benign fibroproliferative skin tumors that can cause disfigurement and disability." | 1.51 | Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence. ( Chong, T; Costa, C; Karimpour-Fard, A; LaRanger, R; Mathes, D; Wright, WE, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.18) | 18.7374 |
| 1990's | 1 (1.18) | 18.2507 |
| 2000's | 19 (22.35) | 29.6817 |
| 2010's | 31 (36.47) | 24.3611 |
| 2020's | 33 (38.82) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 4 |
| Li, Z | 2 |
| Hu, J | 3 |
| Zhan, S | 2 |
| Wang, M | 3 |
| Wang, L | 3 |
| Su, X | 1 |
| Choi, C | 1 |
| Mukovozov, I | 1 |
| Jazdarehee, A | 1 |
| Rai, R | 1 |
| Sachdeva, M | 1 |
| Shunmugam, M | 1 |
| Zaslavsky, K | 1 |
| Byun, S | 1 |
| Barankin, B | 1 |
| Erlendsson, AM | 1 |
| Rosenberg, LK | 1 |
| Lerche, CM | 1 |
| Togsverd-Bo, K | 1 |
| Wiegell, SR | 1 |
| Karmisholt, K | 1 |
| Philipsen, PA | 1 |
| Hansen, ACN | 1 |
| Janfelt, C | 1 |
| Holmes, J | 1 |
| Rossi, A | 1 |
| Haedersdal, M | 1 |
| Yuan, C | 1 |
| Zhang, X | 1 |
| Yan, Y | 1 |
| Wang, B | 1 |
| Li, L | 1 |
| Attwa, E | 1 |
| Khater, MH | 1 |
| Selim, HM | 1 |
| Essam, R | 1 |
| Leszczynski, R | 1 |
| da Silva, CA | 1 |
| Pinto, ACPN | 1 |
| Kuczynski, U | 1 |
| da Silva, EM | 1 |
| Wu, W | 1 |
| Zhao, Y | 1 |
| Chen, Y | 1 |
| Zhong, A | 1 |
| Wu, H | 1 |
| Dong, G | 1 |
| Qu, C | 1 |
| Jin, Q | 1 |
| Worley, B | 1 |
| Kim, K | 1 |
| Jain-Poster, K | 1 |
| Reynolds, KA | 1 |
| Merkel, EA | 1 |
| Kang, BY | 1 |
| Dirr, MA | 1 |
| Anvery, N | 1 |
| Christensen, RE | 1 |
| Hisham, FI | 1 |
| Ibrahim, SA | 1 |
| Asadbeigi, SN | 1 |
| Poon, E | 1 |
| Alam, M | 1 |
| Bekkers, VZ | 1 |
| Bik, L | 1 |
| van Huijstee, JC | 1 |
| Wolkerstorfer, A | 1 |
| Prens, EP | 1 |
| van Doorn, MBA | 1 |
| Walsh, LA | 1 |
| Wu, E | 1 |
| Pontes, D | 1 |
| Kwan, KR | 1 |
| Poondru, S | 1 |
| Miller, CH | 1 |
| Kundu, RV | 1 |
| Dika, E | 1 |
| Mussi, M | 1 |
| Lambertini, M | 1 |
| Vaccari, S | 1 |
| Baraldi, C | 1 |
| Campione, E | 1 |
| Scotti, B | 1 |
| Stancic, BH | 1 |
| Zengarini, C | 1 |
| Xia, Y | 1 |
| Wang, Y | 1 |
| Hao, Y | 1 |
| Shan, M | 1 |
| Liu, H | 1 |
| Liang, Z | 1 |
| Kuang, X | 1 |
| Rimmer, SN | 1 |
| Chandy, RJ | 1 |
| Khan, D | 1 |
| Feldman, SR | 1 |
| Rosa-Nieves, PM | 1 |
| Plampton, K | 1 |
| Evans, T | 1 |
| Whitley, MJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Post-Surgical Intralesional Injection With Triamcinolone Versus Triamcinolone Plus Fluorouracil in the Treatment of Keloids[NCT04710719] | 7 participants (Actual) | Interventional | 2021-02-01 | Completed | |||
| The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair[NCT03219580] | Phase 3 | 50 participants (Anticipated) | Interventional | 2017-05-20 | Enrolling by invitation | ||
| Effect of Cryotherpy on Hypertrophic Scar[NCT04532840] | Phase 2/Phase 3 | 60 participants (Actual) | Interventional | 2019-04-15 | Active, not recruiting | ||
| Open, Non-comparative, Multicentre Clinical Investigation to Evaluate the Performance and Safety of the Medical Device Plenhyage® (Polymerised Polynucleotides Dermal Filler) in the Treatment of Dermal Tissue Defects[NCT05239117] | 48 participants (Actual) | Interventional | 2022-03-30 | Active, not recruiting | |||
| Assessing and Improving Patient Knowledge About Keloids[NCT01176877] | 40 participants (Actual) | Interventional | 2010-08-31 | Completed | |||
| Intra-lesional ACE Inhibitor for Treatment of Hypertrophic Scars[NCT05259137] | Phase 2/Phase 3 | 30 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| Effect of Pulse Width of a 595-nm Flashlamp-pumped Pulsed-dye Laser on the Treatment Response of Keloidal and Hypertrophic Sternotomy Scars[NCT00142441] | 19 participants | Interventional | 2003-06-30 | Completed | |||
| EGF-loaded Chitosan to Facilitate Epithelial Healing And Prevent Scar Formation of Cesarean Wound[NCT04211597] | 60 participants (Actual) | Interventional | 2017-09-05 | Completed | |||
| Comparison of the Effectiveness in Prevention of Hypertrophic Scars or Keloids Between Silicone Sheet, Silicone Gel and Paper Steri-strip-A Randomised Controlled Trial.[NCT00849004] | 75 participants (Anticipated) | Interventional | 2009-03-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
All subjects completed a written questionnaire to assess knowledge about keloid scars before an educational lecture about keloids, immediately after the educational lecture about keloids, and 3 months after the educational lecture about keloids. This written questionnaire to assess knowledge about keloid scars contained 19 questions related to risk factors for developing keloid scars, keloid scar prevention, and keloid scar treatment. A correct response to a question was awarded 1 point and all correct responses were summed to achieve a total score. Possible total score ranged from 0 to 19. A score of 0 is associated with worse knowledge about keloid scars and a score of 19 is associated with better knowledge about keloid scars. (NCT01176877)
Timeframe: immediately before and after a 5 minute educational lecture
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Pre-educational lecture score | Immediate post-educational lecture score | |
| Keloid Scar | 12.9 | 18.3 |
All subjects completed a written questionnaire to assess knowledge about keloid scars before an educational lecture about keloids, immediately after the educational lecture about keloids, and 3 months after the educational lecture about keloids. This written questionnaire to assess knowledge about keloid scars contained 19 questions related to risk factors for developing keloid scars, keloid scar prevention, and keloid scar treatment. A correct response to a question was awarded 1 point and all correct responses were summed to achieve a total score. Possible total score ranged from 0 to 19. A score of 0 is associated with worse knowledge about keloid scars and a score of 19 is associated with better knowledge about keloid scars. (NCT01176877)
Timeframe: before and 3 months after a 5 minute educational lecture
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Pre-educational lecture score | 3 months post-educational lecture score | |
| Keloid Scars | 13.2 | 16.8 |
26 reviews available for fluorouracil and Keloid
| Article | Year |
|---|---|
Management of hypertrophic scars in adults: A systematic review and meta-analysis.
Topics: Adult; Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Silicones; Treatment Outcome; Triamcino | 2022 |
Laser therapy for treating hypertrophic and keloid scars.
Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di | 2022 |
Comparing the Efficacy of Multiple Drugs Injection for the Treatment of Hypertrophic Scars and Keloid: A Network Meta-Analysis.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Network Meta-Analysis; Treatment Outcome | 2023 |
Treatment of traumatic hypertrophic scars and keloids: a systematic review of randomized control trials.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Hypertrophy; Injections, Intralesional; Keloid; Qualit | 2023 |
Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review.
Topics: Acne Vulgaris; Dermatology; Fluorouracil; Humans; Keloid; Treatment Outcome; Triamcinolone Acetonide | 2023 |
Keloid treatments: an evidence-based systematic review of recent advances.
Topics: Adrenal Cortex Hormones; Fluorouracil; Humans; Keloid; Prospective Studies; Treatment Outcome; Verap | 2023 |
Recurrence rates in the treatment of keloids and hypertrophic scars with intralesional triamcinolone combined with other intralesional agents.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Treatment Outcome; Triamcinolone | 2023 |
Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.
Topics: Cicatrix, Hypertrophic; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intralesional; | 2020 |
Keloids: a review of therapeutic management.
Topics: Fluorouracil; Humans; Injections, Intralesional; Keloid; Recurrence; Steroids | 2021 |
[Meta-analysis of the effects of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating keloids].
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intralesional; Keloid; Treatment Outcom | 2020 |
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.
Topics: Atrophy; Burns; Cicatrix, Hypertrophic; Culture Media; Fluorouracil; Humans; Injections, Intralesion | 2021 |
Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature.
Topics: Aminoquinolines; Bleomycin; Cryosurgery; Dermatologic Agents; Electric Stimulation; Fluorouracil; Hu | 2013 |
Intralesional treatment for keloids and hypertrophic scars: a review.
Topics: Adrenal Cortex Hormones; Antibiotics, Antineoplastic; Antimetabolites; Bleomycin; Calcium Channel Bl | 2013 |
Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Aminoquinolines; Anti-Inflammatory Agents; Antineop | 2014 |
Intralesional 5-fluorouracil in keloid treatment: a systematic review.
Topics: Dermatologic Agents; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Glucocor | 2015 |
Could 5-Fluorouracil or Triamcinolone Be an Effective Treatment Option for Keloid After Surgical Excision? A Meta-Analysis.
Topics: Antimetabolites; Fluorouracil; Glucocorticoids; Humans; Keloid; Treatment Outcome; Triamcinolone | 2016 |
Keloids and Hypertrophic Scars: A Spectrum of Clinical Challenges.
Topics: Adjuvants, Immunologic; Aminoquinolines; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Anti | 2016 |
Current options for the treatment of pathological scarring.
Topics: Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Humans; Keloid; Laser Therapy | 2016 |
Current options for the treatment of pathological scarring.
Topics: Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Humans; Keloid; Laser Therapy | 2016 |
Current options for the treatment of pathological scarring.
Topics: Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Humans; Keloid; Laser Therapy | 2016 |
Current options for the treatment of pathological scarring.
Topics: Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Humans; Keloid; Laser Therapy | 2016 |
Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis.
Topics: Anti-Inflammatory Agents; Cicatrix, Hypertrophic; Drug Therapy, Combination; Female; Fluorouracil; H | 2017 |
Comparative Results in Treatment of Keloids With Intralesional 5-FU/Kenalog, 5-FU/Verapamil, Enalapril Alone,Verapamil Alone, and Laser: A Case Report and Review of the Literature.
Topics: Adult; Drug Therapy, Combination; Enalapril; Fluorouracil; Humans; Injections, Intralesional; Keloid | 2016 |
Antimitotic drug injections and radiotherapy: a review of the effectiveness of treatment for hypertrophic scars and keloids.
Topics: Adrenal Cortex Hormones; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antimitotic A | 2008 |
Management of keloids and hypertrophic scars.
Topics: Bleomycin; Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Glucocorticoids; Humans; Keloid; Recur | 2009 |
Management of keloids and hypertrophic scars.
Topics: Bleomycin; Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Glucocorticoids; Humans; Keloid; Recur | 2009 |
Management of keloids and hypertrophic scars.
Topics: Bleomycin; Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Glucocorticoids; Humans; Keloid; Recur | 2009 |
Management of keloids and hypertrophic scars.
Topics: Bleomycin; Cicatrix, Hypertrophic; Cryotherapy; Fluorouracil; Glucocorticoids; Humans; Keloid; Recur | 2009 |
A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Bleomycin; Cicatrix, Hypertrophic; Colchicine; Drug Ther | 2009 |
The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review.
Topics: Antineoplastic Agents; Bleomycin; Cicatrix; Fluorouracil; Humans; Hypertrophy; Interferon-alpha; Kel | 2010 |
Medical and surgical therapies for keloids.
Topics: Adrenal Cortex Hormones; Aminoquinolines; Fluorouracil; Humans; Imiquimod; Injections, Subcutaneous; | 2004 |
Medical and surgical therapies for keloids.
Topics: Adrenal Cortex Hormones; Aminoquinolines; Fluorouracil; Humans; Imiquimod; Injections, Subcutaneous; | 2004 |
Medical and surgical therapies for keloids.
Topics: Adrenal Cortex Hormones; Aminoquinolines; Fluorouracil; Humans; Imiquimod; Injections, Subcutaneous; | 2004 |
Medical and surgical therapies for keloids.
Topics: Adrenal Cortex Hormones; Aminoquinolines; Fluorouracil; Humans; Imiquimod; Injections, Subcutaneous; | 2004 |
Keloid pathogenesis and treatment.
Topics: Antimetabolites; Collagen; Combined Modality Therapy; Extracellular Matrix; Fibroblasts; Fluorouraci | 2006 |
Keloid pathogenesis and treatment.
Topics: Antimetabolites; Collagen; Combined Modality Therapy; Extracellular Matrix; Fibroblasts; Fluorouraci | 2006 |
Keloid pathogenesis and treatment.
Topics: Antimetabolites; Collagen; Combined Modality Therapy; Extracellular Matrix; Fibroblasts; Fluorouraci | 2006 |
Keloid pathogenesis and treatment.
Topics: Antimetabolites; Collagen; Combined Modality Therapy; Extracellular Matrix; Fibroblasts; Fluorouraci | 2006 |
20 trials available for fluorouracil and Keloid
| Article | Year |
|---|---|
A one-time pneumatic jet-injection of 5-fluorouracil and triamcinolone acetonide for treatment of hypertrophic scars-A blinded randomized controlled trial.
Topics: Cicatrix, Hypertrophic; Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intralesional; | 2022 |
THE USAGE OF RADIOFREQUENCY ABLATION FOR TREATMENT OF KELOIDS AND HYPERTROPHIC SCARS.
Topics: Adult; Catheter Ablation; Cicatrix, Hypertrophic; Combined Modality Therapy; Female; Fluorouracil; H | 2019 |
Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Fluorouracil; Glucocorticoi | 2020 |
Botulinum toxin type A versus 5-Fluorouracil in treatment of keloid.
Topics: Adolescent; Adult; Botulinum Toxins, Type A; Female; Fluorouracil; Follow-Up Studies; Humans; Hyperp | 2021 |
Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial.
Topics: Adult; Brachytherapy; Elastic Modulus; Elasticity Imaging Techniques; Female; Fluorouracil; Humans; | 2021 |
The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: A randomized control trial.
Topics: Adult; Body Piercing; Combined Modality Therapy; Dermatologic Surgical Procedures; Drug Therapy, Com | 2018 |
Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.
Topics: Adult; Body Piercing; Burns; Cicatrix, Hypertrophic; Double-Blind Method; Drug Therapy, Combination; | 2019 |
Treatment of keloid scars with intralesional triamcinolone and 5-fluorouracil injections - a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Dermatologic Agents; Double-Blind Metho | 2019 |
Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars.
Topics: Adult; Cicatrix, Hypertrophic; Drug Therapy, Combination; Female; Fluorouracil; Humans; Injections, | 2014 |
Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cicatrix, Hypertrophic; Double-Blind Method; Drug | 2009 |
[Clinical study of auricular keloid treatment with both surgical excision and intralesional injection of low-dose 5-fluorouracil and corticosteroids].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Combined Modality Therapy; Ear, External; Female; Fluoro | 2009 |
Effects of combined intralesional 5-Fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study.
Topics: Administration, Topical; Adult; Double-Blind Method; Drug Therapy, Combination; Female; Fluorouracil | 2011 |
Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids.
Topics: Administration, Topical; Adult; Double-Blind Method; Fluorouracil; Humans; Injections, Intralesional | 2012 |
Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments.
Topics: Adrenal Cortex Hormones; Adult; Aged; Biopsy, Needle; Cicatrix, Hypertrophic; Drug Therapy, Combinat | 2002 |
Intralesional 5-fluorouracil as a treatment modality of keloids.
Topics: Adolescent; Adult; Antimetabolites; Child; Fluorouracil; Humans; Keloid; Middle Aged; Prospective St | 2004 |
[Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil].
Topics: Adrenal Cortex Hormones; Adult; Combined Modality Therapy; Female; Fluorouracil; Humans; Hyperplasia | 2006 |
New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars.
Topics: Adult; Cicatrix, Hypertrophic; Combined Modality Therapy; Drug Therapy, Combination; Female; Fluorou | 2006 |
Treatment of inflamed hypertrophic scars using intralesional 5-FU.
Topics: Acne Vulgaris; Adult; Aged; Anti-Inflammatory Agents; Antimetabolites; Cicatrix; Female; Fluorouraci | 1999 |
The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision.
Topics: Adult; Biopsy; Female; Fluorouracil; Humans; Keloid; Male; Pilot Projects; Sodium Chloride; Sutures; | 2001 |
Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids.
Topics: Female; Fluorouracil; Humans; Immunosuppressive Agents; Injections, Intralesional; Keloid; Male; Tre | 2002 |
39 other studies available for fluorouracil and Keloid
| Article | Year |
|---|---|
Treatment of acne by subcutaneous injection of low-concentration 5-Fluorouracil.
Topics: Acne Vulgaris; Fluorouracil; Humans; Injections, Intralesional; Injections, Subcutaneous; Keloid | 2022 |
Treatment of sebaceous cysts in keloids: Ultrapulse mode-fractionated carbon dioxide lasers combined with injection of low-concentration triamcinolone acetonide and 5-fluorouracil.
Topics: Epidermal Cyst; Fluorouracil; Humans; Injections, Intralesional; Keloid; Lasers, Gas; Treatment Outc | 2022 |
Sequential therapy with intralesional injections and superficial X-ray therapy in 96 keloids.
Topics: Combined Modality Therapy; Fluorouracil; Humans; Injections, Intralesional; Keloid; Treatment Outcom | 2022 |
Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Hyperpigmentation; Injections, Intralesional; Keloi | 2022 |
Contour first-retrospective study of an algorithmic approach of auricular keloids.
Topics: Ear Auricle; Ear, External; Fluorouracil; Humans; Keloid; Recurrence; Retrospective Studies; Treatme | 2023 |
Postsurgical hypertrophic scars after nonmelanoma skin cancer surgical excision: clinical and confocal microscopy outcomes of topical 5-fluorouracil in an adjuvant setting.
Topics: Adjuvants, Immunologic; Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Microscopy, Confocal; | 2023 |
Deciphering the single-cell transcriptome network in keloids with intra-lesional injection of triamcinolone acetonide combined with 5-fluorouracil.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Injections, Intralesional; Keloid; Transcriptome; T | 2023 |
Successful Treatment of a Keloid With Surgical Excision Followed by Pentoxifylline, Intralesional Corticosteroid, and Intralesional 5-Fluorouracil.
Topics: Adrenal Cortex Hormones; Fluorouracil; Humans; Injections, Intralesional; Keloid; Pentoxifylline; Tr | 2023 |
The tunneling technique of intralesional 5-fluorouracil in combination with triamcinolone injection for intractable keloids.
Topics: Fluorouracil; Humans; Injections, Intralesional; Keloid; Treatment Outcome; Triamcinolone; Triamcino | 2023 |
Comments on "A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery".
Topics: Burns; Child; Cicatrix, Hypertrophic; Fluorouracil; Humans; Keloid; Triamcinolone Acetonide | 2020 |
Comments on"Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomisedcontrol trial".
Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon | 2020 |
Treatment of keloids using 5-fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non-invasive objective measures.
Topics: Fluorouracil; Humans; Injections, Intralesional; Keloid; Treatment Outcome; Triamcinolone Acetonide | 2020 |
Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment.
Topics: Chitosan; Drug Delivery Systems; Fluorouracil; Humans; Keloid; Nanoparticles | 2021 |
Treatment of Keloids by Surgical Excision Combined With 5-Fluorouracil and Betamethasone Injection.
Topics: Adult; Betamethasone; Combined Modality Therapy; Dermatologic Surgical Procedures; Female; Fluoroura | 2021 |
Invited Discussion On: Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-Analysis.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolone | 2020 |
Potentials for implementing pressure-controlled jet injection in management of keloids with intralesional 5FU and corticosteroids.
Topics: Adrenal Cortex Hormones; Fluorouracil; Humans; Injections, Intralesional; Injections, Jet; Keloid; R | 2020 |
Assessment of various intralesional injections in keloid: comparative analysis.
Topics: Fluorouracil; Humans; Injections, Intralesional; Keloid; Treatment Outcome; Triamcinolone Acetonide; | 2022 |
A simple device for ablation of keloidal tissue and serial deposition of intralesional drugs.
Topics: Ablation Techniques; Dermatologic Agents; Fluorouracil; Humans; Injections, Intralesional; Keloid; T | 2018 |
Cells to Surgery Quiz: April 2018.
Topics: Dermatologic Surgical Procedures; Dermis; Diagnosis, Differential; Drug Therapy, Combination; Fibrob | 2018 |
Novel Stereoscopic Optical System for Objectively Measuring Above-Surface Scar Volume-First-Time Quantification of Responses to Various Treatment Modalities.
Topics: Adult; Cicatrix, Hypertrophic; Cryosurgery; Dermatologic Agents; Feasibility Studies; Female; Fluoro | 2018 |
Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence.
Topics: Adaptor Proteins, Signal Transducing; Biopsy; Chemokine CCL2; Dermis; Fluorouracil; Follow-Up Studie | 2019 |
Reply to comments on "comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial".
Topics: Burns; Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid; Triamcinolon | 2020 |
The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study.
Topics: Administration, Topical; Cicatrix, Hypertrophic; Combined Modality Therapy; Dose Fractionation, Radi | 2019 |
Treatment of extensive, recalcitrant keloids using a combination of intralesional cryosurgery, triamcinolone, 5-fluorouracil and hyaluronidase.
Topics: Adrenal Cortex Hormones; Brachytherapy; Cryosurgery; Cryotherapy; Fluorouracil; Humans; Hyaluronoglu | 2019 |
A study of the combination of triamcinolone and 5-fluorouracil in modulating keloid fibroblasts in vitro.
Topics: Analysis of Variance; Apoptosis; Blotting, Western; Cell Cycle; Cell Death; Cell Proliferation; Cell | 2013 |
Current Strategies in the Treatment of Scars and Keloids.
Topics: Antimetabolites, Antineoplastic; Botulinum Toxins, Type A; Cicatrix, Hypertrophic; Cryosurgery; Fluo | 2015 |
Localization of MMP-9 in multinuclear giant cells in keloids after treatment with 5-fluorouracil with or without combination of cryotherapy and cryotherapy alone.
Topics: Cryotherapy; Female; Fluorouracil; Humans; Keloid; Male; Matrix Metalloproteinase 9 | 2017 |
Remodelling of keloid tissue into normal-looking skin.
Topics: Anesthetics, Local; Antimetabolites; Drug Administration Schedule; Drug Therapy, Combination; Female | 2008 |
5-Fluorouracil treatment of problematic scars.
Topics: Adult; Antimetabolites; Cicatrix, Hypertrophic; Disease Progression; Female; Fluorouracil; Follow-Up | 2009 |
Use of a collagen-glycosaminoglycan copolymer (Integra) in combination with adjuvant treatments for reconstruction of severe chest keloids.
Topics: Adult; Aged; Anti-Inflammatory Agents; Chondroitin Sulfates; Chronic Disease; Collagen; Combined Mod | 2010 |
Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts.
Topics: Adolescent; Adult; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Ch | 2010 |
What's new in treatment of keloids? New applications for common therapies, new treatments to come.
Topics: Adjuvants, Immunologic; Aminoquinolines; Fluorouracil; Humans; Imiquimod; Immunosuppressive Agents; | 2011 |
A novel approach for management of ear keloids: results of excision combined with 5-fluorouracil injection.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites; Chi-Square Distribution; Combined Moda | 2012 |
[Emerging strategies for the prevention and therapy of excessive scars].
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Aminoquinolines; Botulinum Toxins, Type A; Cicatrix | 2012 |
Intralesional 5-fluorouracil in the treatment of keloid scars.
Topics: Acne Keloid; Adult; Antimetabolites; Betamethasone; Facial Dermatoses; Female; Fluorouracil; Follow- | 2004 |
Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Child; Female; Fluorouracil; Humans; Injec | 2005 |
Treatment of postdermabrasion facial hypertrophic and keloid scars with intralesional 5-Fluorouracil injections.
Topics: Aged; Antimetabolites, Antineoplastic; Cicatrix, Hypertrophic; Face; Female; Fluorouracil; Humans; I | 2008 |
From the literature: intralesional 5-FU in the treatment of hypertrophic scars and keloids: clinical experience.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Injections, Intralesional; Keloid | 2000 |
Minor surgery for benign and malignant facial lesions.
Topics: Acne Vulgaris; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cicatrix; Cortisone; Curettage; Cyst | 1974 |