Page last updated: 2024-11-12

cypate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cypate: a fluorescent dye; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10963571
CHEMBL ID	2071606
MeSH ID	M000614051

Synonyms (8)

Synonym
cypate
CHEMBL2071606
GRAVJJAQKJDGPM-UHFFFAOYSA-N
3-[(2e)-2-[(2e,4e,6e)-7-[3-(2-carboxyethyl)-1,1-dimethylbenzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]propanoic acid;bromide
95837-47-1
EX-A4740
E86095
317809-26-0

Research Excerpts

Overview

Cypate is an organic material with tumor treatment function, which has photothermal effect.

Excerpt	Reference	Relevance
"Cypate is an organic material with tumor treatment function, which has photothermal effect. "	( Preparation of Composite Cypate Nanoparticles and Its Application in the Treatment of Pediatric Bladder Tumors. Bai, B; Chen, W; Lei, Y; Li, Z; Ma, H; Tao, H; Wang, L; Yang, P; Zhang, N, 2021)	2.37

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID678143	Binding affinity to integrin alphavbeta3 in human A549 cells assessed as cellular uptake after 1 hr by NIR Fluorescence microscopy analysis	2012	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17	Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging.
AID678144	Binding affinity to integrin alphavbeta3 in human A549 cells assessed as cellular uptake after 6 hrs by NIR Fluorescence microscopy analysis	2012	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17	Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	16 (66.67)	24.3611
2020's	8 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.06 (24.57)
Research Supply Index	3.22 (2.92)
Research Growth Index	4.64 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.06)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-nitrobenzyl alcohol [no description available]	2.13	1
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.11	1	elemental platinum; nickel group element atom; platinum group metal atom
gadolinium Gadolinium: An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.	2.11	1	f-block element atom; lanthanoid atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.52	2	copper group element atom; elemental gold
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.13	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	2.21	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a: a photodynamic sensitizer; structure given in first source	2.17	1
gadolinium oxide gadolinium oxide: RN given refers to cpd with MF of Gd2-O3	2.11	1
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.86	3	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	7.21	1	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
ferric ferrocyanide ferric ferrocyanide: antidote to thallium poisoning; RN given refers to Fe(+3)[3:4] salt; structure	3.14	1
ginsenosides ginsenoside : Triterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives.	2.31	1
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	2.17	1	cyanine dye; organic iodide salt	fluorochrome
gambogic acid gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer	2.31	1	pyranoxanthones	metabolite
ginsenoside rb1 [no description available]	2.31	1	ginsenoside; glycoside; tetracyclic triterpenoid	anti-inflammatory drug; anti-obesity agent; apoptosis inhibitor; neuroprotective agent; plant metabolite; radical scavenger
chlorophyll a Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.	2.17	1	chlorophyll; methyl ester	cofactor
chitosan [no description available]	2.13	1
folic acid folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.	2.31	1	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.79	9
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.79	9
Infectious Diseases [description not available]	3.14	1
Communicable Diseases An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host.	3.14	1
Experimental Neoplasms [description not available]	2.69	2
Bladder Cancer [description not available]	2.31	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.31	1
Cancer of Colon [description not available]	2.17	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.17	1
Bone Cancer [description not available]	2.21	1
Osteogenic Sarcoma [description not available]	2.21	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	2.21	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	2.21	1
Disease Exacerbation [description not available]	2.21	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.1	1
Experimental Mammary Neoplasms [description not available]	2.11	1
Breast Cancer [description not available]	2.53	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.53	2

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