carbocyanines has been researched along with furan* in 1 studies
1 other study(ies) available for carbocyanines and furan
Article | Year |
---|---|
Double click: dual functionalized polymeric micelles with antibodies and peptides.
Polymeric nanoparticle micelles provide a possible platform for theranostic delivery, combining the role of therapeutics and diagnostics in one vehicle. To explore dual-functional micelles, the amphiphilic copolymer of poly(d,l-lactide-co-2-methyl-2-carboxytrimethylene carbonate)-graft-poly(ethylene glycol)-X (P(LA-co-TMCC)-g-PEG-X) was self-assembled to form micelles, with X representing either azide or furan. Micelles of P(LA-co-TMCC)-g-PEG-azide and P(LA-co-TMCC)-g-PEG-furan terminal functional groups were used to conjugate dibenzylcyclooctyne and maleimide-modified probes, respectively, taking advantage of orthogonal coupling chemistry. To verify the utility of the dual-functional micelles, trastuzumab-maleimide antibodies and FLAG-dibenzylcyclooctyne peptides were covalently bound by sequential click chemistry reactions. SKOV-3luc cells that were treated with the dual-functionalized micelles showed colocalization of the antibodies and peptides by confocal imaging, demonstrating the promise of this approach. Topics: Alkynes; Antibodies, Monoclonal, Humanized; Azides; Carbocyanines; Carbonates; Cell Line, Tumor; Click Chemistry; Furans; Humans; Hydrazines; Maleimides; Micelles; Oligopeptides; Peptides; Polyesters; Polyethylene Glycols; Trastuzumab | 2013 |