1,2-(palmitoyl-nbd-aminocaproyl)phosphatidylethanolamine profile

## 1,2-(Palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine (NBD-PE)

**1,2-(Palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine (NBD-PE)** is a fluorescently labeled phospholipid. It is a derivative of phosphatidylethanolamine (PE), a common phospholipid found in cell membranes.

**Here's a breakdown of the structure and key components:**

* **Palmitoyl:** A saturated fatty acid chain with 16 carbon atoms. This provides hydrophobic properties to the molecule.
* **NBD:** 7-nitrobenz-2-oxa-1,3-diazole, a fluorescent dye. This allows for easy visualization and tracking of the lipid within cells or membranes.
* **Aminocaproyl:** A six-carbon amino acid linker that attaches the NBD dye to the palmitoyl chain.
* **Phosphatidylethanolamine (PE):** A phospholipid with a polar head group (ethanolamine) and two fatty acid tails.

**Why is NBD-PE important for research?**

NBD-PE is a valuable tool in various biological research fields due to its fluorescence properties. It enables researchers to:

* **Track lipid movement and dynamics:** NBD-PE can be incorporated into cell membranes and tracked in real-time using fluorescence microscopy. This helps understand the fluidity and movement of lipids within membranes.
* **Study membrane organization and structure:** NBD-PE can be used to investigate the organization of different lipid domains within cell membranes, such as rafts and microdomains.
* **Investigate membrane transport:** NBD-PE can be used to track the movement of lipids across membranes, providing insights into lipid transport pathways.
* **Study membrane fusion:** NBD-PE can be used to study the fusion of membranes during processes like vesicle trafficking and exocytosis.
* **Analyze lipid metabolism:** NBD-PE can be used to investigate the synthesis, degradation, and transport of phospholipids in cells.

**Specific research applications include:**

* **Studying membrane fluidity and phase transitions**
* **Investigating lipid-protein interactions**
* **Analyzing lipid trafficking and sorting**
* **Developing new diagnostic tools for lipid disorders**

**Overall, NBD-PE is a versatile and powerful tool for studying membrane dynamics and functions in various biological systems.**

**Note:** NBD-PE is often used alongside other fluorescent probes to study different aspects of membrane biology.

ID Source	ID
PubMed CID	130586
MeSH ID	M0148423

Synonym
c6-nbd-pe
[(2s)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanoyloxy]propyl] hexadecanoate
hexadecanoic acid, 3-(((2-aminoethoxy)hydroxyphosphinyl)oxy)-2-((6-((7-nitro-4-benzofurazanyl)amino)-1-oxohexyl)oxy)propyl ester, (s)-
hexadecanoic acid, 3-(((2-aminoethoxy)hydroxyphosphinyl)oxy)-2-((6-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-1-oxohexyl)oxy)propyl ester, (s)-
108762-10-3
1,2-(palmitoyl-nbd-aminocaproyl)phosphatidylethanolamine
palmitoyl-c6-nbd-pe
DTXSID60148730

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (9.09)	18.7374
1990's	3 (27.27)	18.2507
2000's	7 (63.64)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen carbonate Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.. hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.	2	1	carbon oxoanion	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
dithionite Dithionite: Dithionite. The dithionous acid ion and its salts.	2.41	2	sulfur oxide; sulfur oxoanion
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.04	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.01	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.01	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
nitrilotriacetic acid Nitrilotriacetic Acid: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.)	2.04	1	NTA; tricarboxylic acid	carcinogenic agent; nephrotoxic agent
4-chloro-7-nitrobenzofurazan 4-Chloro-7-nitrobenzofurazan: A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.. 4-chloro-7-nitrobenzofurazan : A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at position 4 by chlorine and at position 7 by a nitro group.	3.79	11	benzoxadiazole; C-nitro compound; organochlorine compound	EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.6.1.3 (adenosinetriphosphatase) inhibitor; fluorescent probe; fluorochrome
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.99	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
1,2-oleoylphosphatidylcholine 1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.	2.01	1	phosphatidylcholine(1+)
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	2.04	1	cyanine dye; organic iodide salt	fluorochrome
stains-all stains-all: cationic dye; RN given refers to bromide salt	2.04	1	cyanine dye; organic bromide salt	fluorochrome
oxadiazoles Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.	2.68	3
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	3.7	10	1,2-diacyl-sn-glycero-3-phosphocholine
1-palmitoyl-2-(6-(n-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine 1-hexadecanoyl-2-{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine(1+) in which the acyl groups at C-1 and C-2 are hexadecanoyl and 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]hexanoyl respectively.	3.61	9	1,2-diacyl-sn-glycero-3-phosphocholine(1+)	fluorescent probe
merocyanine dye merocyanine dye: fluorescent dye used for studying axons 2 position on pyrimidine ring may be S or O; RN given refers to Na salt; structure	2	1
glycolipids [no description available]	2	1
nickel nitrilotriacetic acid [no description available]	2.04	1
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	2	1

1,2-(palmitoyl-nbd-aminocaproyl)phosphatidylethanolamine

Cross-References

Synonyms (8)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.45

Study Types

Condition	Indicated	Relationship Strength	Studies	Trials
Cancer of Stomach [description not available]	0	2.01	1	0
Stomach Neoplasms Tumors or cancer of the STOMACH.	0	2.01	1	0