carbocyanines and Hepatoblastoma

carbocyanines has been researched along with Hepatoblastoma* in 1 studies

Other Studies

1 other study(ies) available for carbocyanines and Hepatoblastoma

Article	Year
Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia. Bioorganic & medicinal chemistry letters, 2002, Jun-03, Volume: 12, Issue:11 For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moiety serving as the lipid-chelating anchor for low-density lipoprotein (LDL). One of these conjugates, TCL17, was successfully used to label LDL to give a new NIRF, TCL17-LDL. Ex vivo biological studies on an LDLr overexpressing tumor model, human hepatoblastoma G(2) (HepG(2)), confirmed that this NIRF were internalized selectively by the tumor and detected with high sensitivity by a low-temperature 3-D redox scanner. Topics: Animals; Carbocyanines; Cholesterol Esters; Cholesterol, LDL; Fluorescent Dyes; Genetic Therapy; Hepatoblastoma; Humans; Hyperlipoproteinemia Type II; Imaging, Three-Dimensional; Laurates; Liver Neoplasms; Mice; Receptors, LDL; Spectroscopy, Near-Infrared	2002

Article

Year

Tricarbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia.

Bioorganic & medicinal chemistry letters, 2002, Jun-03, Volume: 12, Issue:11

For monitoring low-density lipoprotein receptors (LDLr) in tumors and in livers of patients with familial hypercholesterolemia (FH) treated with gene therapy, a series of tricarbocyanine cholesteryl laurates were synthesized with the cholesteryl laurate moiety serving as the lipid-chelating anchor for low-density lipoprotein (LDL). One of these conjugates, TCL17, was successfully used to label LDL to give a new NIRF, TCL17-LDL. Ex vivo biological studies on an LDLr overexpressing tumor model, human hepatoblastoma G(2) (HepG(2)), confirmed that this NIRF were internalized selectively by the tumor and detected with high sensitivity by a low-temperature 3-D redox scanner.

Topics: Animals; Carbocyanines; Cholesterol Esters; Cholesterol, LDL; Fluorescent Dyes; Genetic Therapy; Hepatoblastoma; Humans; Hyperlipoproteinemia Type II; Imaging, Three-Dimensional; Laurates; Liver Neoplasms; Mice; Receptors, LDL; Spectroscopy, Near-Infrared

2002