viridin profile

Viridin is a fungal metabolite produced by various species of fungi, including *Trichoderma* and *Aspergillus*. It exhibits a range of biological activities, including antifungal, antibacterial, and antiviral properties. Viridin is known to inhibit the growth of bacteria, yeasts, and molds, and it has been shown to be effective against certain types of cancer cells. The compound is also known to have insecticidal and herbicidal activity. Viridin's biological activity stems from its ability to interfere with the synthesis of proteins and nucleic acids in target organisms. Its unique chemical structure, characterized by a fused pyranone-pyrone ring system, contributes to its biological activity. The biosynthesis of viridin involves a series of enzymatic reactions that are not fully understood. Viridin is a potential lead compound for the development of new drugs with antifungal, antibacterial, and anticancer activities. Research on viridin focuses on understanding its biosynthesis, its mechanism of action, and its potential applications in medicine and agriculture. '

viridin: bacteriocins of alpha-hemolytic streptococcal isolates; RN given refers to (1S-(1alpha,2alpha,11balpha))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	94257
CHEMBL ID	2158159
SCHEMBL ID	150041
MeSH ID	M0058865

Synonym
18-norandrosta-5,8,11,13-tetraeno[6,5,4-bc]furan-3,7,17-trione, 1-hydroxy-2-methoxy-, (1.beta.,2.beta.)-
viridin
einecs 221-987-6
x5kjo207mo ,
unii-x5kjo207mo
cyclopenta(7,8)phenanthro(10,1-bc)furan-3,6,9(2h)-trione, 1,7,8,11b-tetrahydro-1-hydroxy-2-methoxy-11b-methyl-, (1s,2r,11bs)-
CHEMBL2158159
1.beta.-hydroxy-2.beta.-methoxy-18-norandrosta-5,8,11,13-tetraeno(6,5,4-bc)furan-3,7,17-trione
viridin [mi]
SCHEMBL150041
(1r,17s,18s)-18-hydroxy-17-methoxy-1-methyl-13-oxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),3,5(9),12(19),14-pentaene-6,11,16-trione
Q21099545
DTXSID00889372
HY-N10189
CS-0372085

Excerpt	Relevance	Reference
" In vivo, a SAV dosing of 1 mg/kg once in 48 hours (i."	( The antiproliferative cytostatic effects of a self-activating viridin prodrug. Aikawa, E; Blois, J; Cantley, LC; Ellson, C; Figueiredo, JL; Josephson, L; Kohler, R; Smith, A; Weissleder, R; Yaffe, MB; Yuan, H, 2009)	0.59

Assay ID	Title	Year	Journal	Article
AID694028	Inhibition of PI3K	2012	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 22, Issue:22	Viridin analogs derived from steroidal building blocks.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (23.08)	18.7374
1990's	3 (11.54)	18.2507
2000's	10 (38.46)	29.6817
2010's	6 (23.08)	24.3611
2020's	1 (3.85)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thymidine [no description available]	1.95	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
uridine [no description available]	1.95	1	uridines	drug metabolite; fundamental metabolite; human metabolite
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	1.95	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	1.97	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
3-hydroxybutanal [no description available]	2.07	1
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.11	1	catechin	antioxidant; plant metabolite
2-benzoquinone 2-benzoquinone: reacts with methionines of RNAase at pH 1; reagent for determining conformational differences in related proteins. 1,2-benzoquinone : A benzoquinone resulting from the formal oxidation of catechol.	2.05	1	1,2-benzoquinones; benzoquinone
chromic acid [no description available]	6.94	1	chromium oxoacid	oxidising agent
chromates Chromates: Salts of chromic acid containing the CrO(2-)4 radical.. chromate(2-) : A chromium oxoanion resulting from the removal of two protons from chromic acid.	1.94	1	chromium oxoanion; divalent inorganic anion	oxidising agent
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.11	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
benzocyclobutene benzocyclobutene : A carbobicyclic compound that is benzene fused to a cyclobutane ring.	2.02	1	carbobicyclic compound	metabolite
wortmannin [no description available]	9.51	7	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent
viridiol viridiol: structure given in first source	2.73	3
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	2.05	1	cyanine dye; organic iodide salt	fluorochrome
px-866 PX-866: inhibitor of phosphoinositide-3-kinase signaling with antitumor activity; structure in first source. PX-866 : An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.	2.02	1	acetate ester; delta-lactone; organic heterotetracyclic compound; tertiary amino compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.07	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.07	1
Acute Confusional Senile Dementia [description not available]	2.11	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.47	2
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.11	1
Innate Inflammatory Response [description not available]	2.04	1
Airway Hyper-Responsiveness [description not available]	2.04	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.04	1
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.04	1
Experimental Neoplasms [description not available]	2.05	1
Adjuvant Arthritis [description not available]	2.05	1
Autoimmune Disease [description not available]	2.05	1
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	2.05	1
Cancer of Colon [description not available]	2.02	1
Cancer of Lung [description not available]	2.02	1
Cancer of Ovary [description not available]	2.02	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.02	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.02	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.02	1
Bile Duct Obstruction [description not available]	1.97	1
Cholestasis Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).	1.97	1

viridin

Description

Cross-References

Synonyms (15)

Research Excerpts

Dosage Studied

Bioassays (1)

Research

Studies (26)

Market Indicators

Research Demand Index: 53.19

Study Types