Page last updated: 2024-10-15

noc 9

Description

NOC 9: nitrogen oxide releaser [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135487863
CHEMBL ID151443
CHEMBL ID1163045
SCHEMBL ID248520
SCHEMBL ID12143025
MeSH IDM0261441

Synonyms (20)

Synonym
noc 9
1-hexanamine, 6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-n-methyl-
mahma nonoate
noc-9
6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-n-methyl-1-hexanamine
CHEMBL151443
146724-86-9
1-hydroxy-2-oxo-3-(n-methyl-6-aminohexyl)-3-methyl-1-triazene
CHEMBL1163045
n-hydroxy-n-[methyl-[6-(methylamino)hexyl]amino]nitrous amide
SCHEMBL248520
SCHEMBL12143025
DTXSID60163463
(z)-hydroxyimino-[methyl-[6-(methylamino)hexyl]amino]-oxidoazanium
J-008251
SR-01000946618-1
sr-01000946618
1-hexanamine, 6-(2-hydroxy-1-methyl-2-nitrosohydrazinyl)-n-methyl-
CS-0139745
HY-134216

Bioavailability

ExcerptReference
" These findings may represent an important contribution to reduced NO bioavailability in the microvasculature in diabetes."( Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycated hemoglobin.
Frenneaux, MP; James, PE; Lang, D; Milsom, AB; Tufnell-Barret, T, 2004
)
" The slow HNO-donor 1 demonstrates weak thiol-insensitive vasorelaxation, indicating HNO release kinetics determine HNO bioavailability and activity."( Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
Brandon, A; Crawford, JH; DuMond, JF; Honovar, J; Isbell, TS; King, SB; Patel, RP; Shoman, ME; Vitturi, DA; White, CR, 2011
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID30226Apparent half life period in PBS buffer2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
More lipophilic dialkyldiamine-based diazeniumdiolates: synthesis, characterization, and application in preparing thromboresistant nitric oxide release polymeric coatings.
AID28894Partition coefficient (logP)2003Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
More lipophilic dialkyldiamine-based diazeniumdiolates: synthesis, characterization, and application in preparing thromboresistant nitric oxide release polymeric coatings.
AID577795Vasodilatory activity in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstriction compound treated 5 mins after 1 uM soluble guanylate cyclase inhibitor ODQ treatment2011Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
AID577794Vasodilatory activity in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstriction at 0.01 nM to 100 uM2011Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
AID577796Vasodilatory activity in Sprague-Dawley rat thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstriction compound treated 5 mins after 200 uM NO-scavenger C-PTIO treatment2011Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
AID320544Antiproliferative activity against human HL60 cells assessed as nitric oxide release2008Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound.
AID577803Potentiation of MahmaNonoate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM2011Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
AID577802Potentiation of 1-Nitrosocyclohexyl acetate induced- vasodilatory activity in Sprague-Dawley rat thoracic aorta at 1 mM2011Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (12.00)18.2507
2000's17 (68.00)29.6817
2010's5 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (96.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]