Page last updated: 2024-12-11

1-oleoyl-2-palmitoylphosphatidylcholine

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Description

## 1-Oleoyl-2-palmitoylphosphatidylcholine (POPC)

**What it is:**

1-Oleoyl-2-palmitoylphosphatidylcholine (POPC) is a type of phospholipid, a key component of cell membranes. It's a **phosphatidylcholine**, meaning it has a choline head group and two fatty acid tails.

* **Oleoyl:** The first fatty acid tail is oleic acid, an unsaturated fatty acid with a cis double bond.
* **Palmitoyl:** The second fatty acid tail is palmitic acid, a saturated fatty acid.

This specific combination of fatty acids gives POPC its unique properties and makes it a common model phospholipid in research.

**Why it's important for research:**

POPC plays a crucial role in several areas of scientific research, including:

* **Membrane biology:** POPC is a major component of eukaryotic cell membranes, forming the lipid bilayer that acts as a barrier and regulates the passage of molecules. Researchers study POPC to understand the structure, dynamics, and function of cell membranes.
* **Drug delivery:** POPC is used in the development of liposomes, artificial vesicles that can encapsulate and deliver drugs to specific cells or tissues. Its biocompatibility and ability to form stable structures make it a suitable material for drug delivery systems.
* **Biophysics:** POPC serves as a model system for studying the physical properties of lipid bilayers, such as fluidity, permeability, and phase transitions. These studies provide insights into the fundamental principles of membrane organization and function.
* **Biochemistry:** POPC is involved in various cellular processes, including signal transduction, membrane trafficking, and enzyme activity. Researchers use POPC to study the interactions between lipids and proteins, and how these interactions affect cellular function.
* **Nano- and microfluidics:** POPC is used to fabricate microfluidic devices for drug delivery, biosensing, and other applications. Its ability to self-assemble into well-defined structures makes it a versatile material for microfluidic applications.

**Overall, POPC is a versatile and widely studied phospholipid that provides valuable insights into the fundamental principles of membrane biology and serves as a key component in various research applications.**

1-oleoyl-2-palmitoylphosphatidylcholine: RN given refers to (Z)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6449792
MeSH IDM0107436

Synonyms (12)

Synonym
3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-((1-oxohexadecyl)oxy)-, inner salt, 4-oxide, (z)-
17118-56-8
1-oleoyl-2-palmitoylphosphatidylcholine
1-oleoyl-2-palmitoyl lecithin
[2-hexadecanoyloxy-3-[(z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
etc-588
DB05456
8057-53-2 (from egg yolk)
(z)-3-(oleoyloxy)-2-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate.
phosphatidyl choline (from egg yolk)
Q27095679
AKOS040753529
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.00)18.7374
1990's6 (30.00)18.2507
2000's10 (50.00)29.6817
2010's3 (15.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.00 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index5.09 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.00%)5.53%
Reviews1 (5.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]