Any compound which induces a partially or terminally differentiated cell to revert to an earlier developmental stage.
ChEBI ID: 70724
| Member | Definition | Class |
|---|---|---|
| 2-(4-morpholinoanilino)-6-cyclohexylaminopurine | A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively. | reversine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (19.05) | 29.6817 |
| 2010's | 52 (61.90) | 24.3611 |
| 2020's | 16 (19.05) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (7.06%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 79 (92.94%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 5.4168 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 2.9411 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.3872 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 7.0795 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 2.9411 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.6600 | 1 | 1 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 0.2550 | 2 | 2 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 0.2875 | 2 | 2 |
| Aurora kinase C | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Chain A, Serine/threonine-protein Kinase 12-a | Xenopus laevis (African clawed frog) | IC50 | 0.5000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Mus musculus (house mouse) | IC50 | 0.0080 | 1 | 1 |
| Dual specificity protein kinase TTK | Homo sapiens (human) | IC50 | 0.0034 | 2 | 2 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A3 | Homo sapiens (human) | Kb | 0.4660 | 1 | 1 |