carbocyanines and Heat-Stroke

Heat stroke is a lethal condition which can cause dysfunction in the central nervous system, multi-organ damage and even death. However, there is still limited knowledge of the detailed mechanism about the roles of lysosomes in heat stroke due to lack of effective tools. Herein, we introduce our previously developed hemicyanine with a large D-π-A structure as the key fluorophore to develop a new fluorescent probe (CPY) for ratiometric mapping of lysosomal pH changes in live cells under a heat shock stimulus.

Topics: Carbocyanines; Cell Survival; Fluorescent Dyes; Heat Stroke; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysosomes; Molecular Structure