1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine

Description

1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine, often abbreviated as **1,2-Bis(10-Hexadienoyloxy)PC**, is a synthetic lipid analogue.

**Structure and Properties:**

* It is a phospholipid with two long fatty acid chains (10(2',4'-hexadienoyloxy)decanoyl) linked to the glycerol backbone, and a choline headgroup.
* The key feature of this lipid is the presence of conjugated dienes (double bonds) in the fatty acid chains, specifically within the 2',4'-positions.

**Importance in Research:**

1,2-Bis(10-Hexadienoyloxy)PC is a valuable research tool because:

* **Membrane Perturbation:** The conjugated diene moieties contribute to its ability to **disrupt membrane structure and function**. This makes it useful for studying:
* **Membrane fluidity and dynamics:** It can be used to alter membrane properties and observe the effects on cell behavior.
* **Protein-membrane interactions:** It can disrupt membrane integrity and influence protein localization and activity.
* **Membrane trafficking and fusion:** It can interfere with the processes involving membrane movement and merging.

* **Photoactive Properties:** The conjugated dienes exhibit **photochemical reactivity** upon exposure to UV light. This characteristic allows for:
* **Photolabeling studies:** Attaching photoreactive molecules to proteins or lipids within membranes.
* **Photoactivation of biological processes:** Using light to trigger specific events or reactions within cells.

* **Model System:** 1,2-Bis(10-Hexadienoyloxy)PC serves as a **model system** for understanding:
* **Lipid bilayer properties:** It provides insight into the behavior and interactions of lipids in artificial membranes.
* **Membrane-related diseases:** It helps researchers study conditions like cancer and neurological disorders where membrane dysfunction is a factor.

**Applications in Research:**

* **Cell biology:** Studying membrane dynamics, protein trafficking, and cellular signaling.
* **Drug delivery:** Developing drug carriers that target specific membranes and enhance drug efficacy.
* **Neuroscience:** Investigating the role of membrane lipids in brain function and neurological disorders.
* **Cancer research:** Understanding the role of membrane changes in cancer development and metastasis.

**In summary, 1,2-Bis(10-Hexadienoyloxy)PC is a valuable tool for researchers in various fields who study membrane structure, function, and interactions.** Its unique structural features and photochemical properties make it an ideal probe for investigating complex biological processes.

1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]