Compounds > 2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)thiopyrylium

Page last updated: 2024-11-13

2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)thiopyrylium

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)thiopyrylium: structure given in first source; RN given refers to chloride [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	23277164
CHEMBL ID	149555
SCHEMBL ID	10584345
MeSH ID	M0229135

Synonyms (13)

Synonym
CHEMBL149555
aa1 cation
unii-j2v5n8t1bl
126172-94-9
j2v5n8t1bl ,
2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)thiopyrylium
2,6-bis(p-aminophenyl)-4-(p-(dimethylamino)phenyl)thiopyrylium chloride
thiopyrylium, 2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)-, chloride
aa-001
aa-1
SCHEMBL10584345
Q27281072
[4-[2,6-bis(4-aminophenyl)thiopyran-4-ylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;chloride

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID52519	compound evaluated for dark induced toxicity toward COLO-26, murine colon carcinoma cell line	2002	Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23	In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1.
AID1166074	Photo-toxicity in mouse Colon 26 cells assessed as reduction in cell surviving fraction at 5 Jcm'-2 of continuous illumination with 360 to 800 nm light incubated for 48 hrs by sulforhodamine B assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.
AID28963	Distribution coefficient between octanol and phosphate buffer at pH6.0	2002	Journal of medicinal chemistry, Nov-07, Volume: 45, Issue:23	In vitro photodynamic properties of chalcogenopyrylium analogues of the thiopyrylium antitumor agent AA1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.58 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.58)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.92	4	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine: structure given in first source. 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine : The cationic form of a C3 cyanine dye having 1,3-diethyl-5,6-dichloroindoleinine units at each end.	2.02	1	0	cyanine dye; indolium ion	fluorochrome
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.01	1	0	chalcogen; nonmetal atom	macronutrient
carbocyanines Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials.	2.02	1	0	cyanine dye; organic iodide salt	fluorochrome
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	2.7	3	0	chalcogen; nonmetal atom	micronutrient
tellurium Tellurium: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.	2.01	1	0	chalcogen; metalloid atom

Condition	Indicated	Relationship Strength	Studies	Trials
Adenocarcinoma, Basal Cell [description not available]	0	2.4	2	0
Bladder Cancer [description not available]	0	1.98	1	0
Cancer of Colon [description not available]	0	1.98	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	1.98	1	0
Malignant Melanoma [description not available]	0	1.98	1	0
Cancer of Ovary [description not available]	0	1.98	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	0	2.4	2	0
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	0	1.98	1	0
Colonic Neoplasms Tumors or cancer of the COLON.	0	1.98	1	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	0	1.98	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	0	1.98	1	0
Animal Mammary Carcinoma [description not available]	0	2	1	0